Benefits of preschool on at-risk student achievement

Historically, education has been a vehicle by which individuals improved their chances for a more productive and personally satisfying life. When the studies of the effects of early childhood education began in the 1960s, the basic question under investigation was, Does preschool education make a difference in the lives of children? Fears at that time were that preschool would be harmful to the development of children and to their relationship with their families

Listening to Voices: Understanding Chinese Students' Journey at a Canadian University

This research explored the motivations of Chinese students to study in Canada and analyzed their cultural adaptation process at a Canadian university. This served the Canadian educational administrators and prospective Chinese students who were interested in studying in Canada. The following three research questions provided the direction for this study: 1 What are Chinese students’ motivations to study in Canada? 2 What are Chinese students’ experiences at Canadian universities and how do their motivations shape their journey in Canada? 3 What challenges and opportunities do Chinese students face in their cultural adaptation, and what strategies do Chinese students think can be applied by Canadian educational administrators to assist Chinese students? A qualitative approach was the research method utilized in this study. Using semi-structured life-story interviews, data were collected from a purposeful sample of four Chinese graduate students studying at a Canadian university. Utilizing a narrative research method, from an emic perspective, I listened to Chinese students’ voices and their life stories and to explore deeply their experiences in Canada. Three theoretical frameworks were employed to analyze the data. The synthesis model was used to explore the decision making process of participants to come to Canada; the push-pull model was employed to identify the factors attracting people to move to another country; and Self- Determined Theory was used to analyze the connection between participants’ motivations to study abroad and their subsequent cultural adaptation. Data collected from semi-structured interviews with four participants indicated that Chinese students were easily attracted to study in Canada by its favorable and tolerant environment, positive reputation for diversity, high quality post-secondary institutions and the possibility of securing a visa relatively easily. In their decision making process, Chinese students were influenced by some important factors: student characteristics, parental factors, and other external important factors. Among those factors influencing Chinese students’ decisions to move to Canada, family was recognized a very important factor and participants’ narratives suggested that having family connections in Canada could be a helpful factor for Chinese students to adapt to a new culture, which was reported as a best case scenario in this research. However, family also acted as a barrier for Chinese students to acquire English proficiency and interact with local people. Findings from this study supported earlier research that suggested students who were more self-determined to study abroad were more likely to succeed academically and had fewer traumas in navigating cross-cultural adaptations

Comparative analysis of the kinomes of three pathogenic trypanosomatids: Leishmania major, Trypanosoma brucei and Trypanosoma cruzi

BACKGROUND: The trypanosomatids Leishmania major, Trypanosoma brucei and Trypanosoma cruzi cause some of the most debilitating diseases of humankind: cutaneous leishmaniasis, African sleeping sickness, and Chagas disease. These protozoa possess complex life cycles that involve development in mammalian and insect hosts, and a tightly coordinated cell cycle ensures propagation of the highly polarized cells. However, the ways in which the parasites respond to their environment and coordinate intracellular processes are poorly understood. As a part of an effort to understand parasite signaling functions, we report the results of a genome-wide analysis of protein kinases (PKs) of these three trypanosomatids. RESULTS: Bioinformatic searches of the trypanosomatid genomes for eukaryotic PKs (ePKs) and atypical PKs (aPKs) revealed a total of 176 PKs in T. brucei, 190 in T. cruzi and 199 in L. major, most of which are orthologous across the three species. This is approximately 30% of the number in the human host and double that of the malaria parasite, Plasmodium falciparum. The representation of various groups of ePKs differs significantly as compared to humans: trypanosomatids lack receptor-linked tyrosine and tyrosine kinase-like kinases, although they do possess dual-specificity kinases. A relative expansion of the CMGC, STE and NEK groups has occurred. A large number of unique ePKs show no strong affinity to any known group. The trypanosomatids possess few ePKs with predicted transmembrane domains, suggesting that receptor ePKs are rare. Accessory Pfam domains, which are frequently present in human ePKs, are uncommon in trypanosomatid ePKs. CONCLUSION: Trypanosomatids possess a large set of PKs, comprising approximately 2% of each genome, suggesting a key role for phosphorylation in parasite biology. Whilst it was possible to place most of the trypanosomatid ePKs into the seven established groups using bioinformatic analyses, it has not been possible to ascribe function based solely on sequence similarity. Hence the connection of stimuli to protein phosphorylation networks remains enigmatic. The presence of numerous PKs with significant sequence similarity to known drug targets, as well as a large number of unusual kinases that might represent novel targets, strongly argue for functional analysis of these molecules

Effects of progesterone on parturition in the tammar, Macropus eugenii

Summary. Tammar wallabies were treated with progesterone injections or implants during late pregnancy to determine whether progesterone withdrawal was essential for parturition. Neither physiological (implanted group) nor pharmacological (injected group) levels of circulating progesterone prevented parturition occurring at about the expected time in about two-thirds of animals that were pregnant. The neonates of both groups were normal in size and weight, but about a third of treated pregnant animals retained their fetuses or aborted. The retained fetuses were retarded in development. Therefore, progesterone treatment had no influence on the duration of gestation, or parturition, in the tammar wallaby, but high progesterone concentrations may interfere with the normal course of development and birth in a proportion of treated animals

A Report to the Parents of Detroit on Decentralization

https://digitalcommons.usm.maine.edu/detroitgeographicalexpedition/1000/thumbnail.jp

Prevalence of prehypertension and its relationship to risk factors for cardiovascular disease in Jamaica: Analysis from a cross-sectional survey

<p>Abstract</p> <p>Background</p> <p>Recent studies have documented an increased risk of cardiovascular disease (CVD) in persons with systolic blood pressures of 120–139 mmHg and/or diastolic blood pressures of 80–89 mmHg, classified as prehypertension in the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. In this paper we estimate the prevalence of prehypertension in Jamaica and evaluate the relationship between prehypertension and other risk factors for CVD.</p> <p>Methods</p> <p>The study used data from participants in the Jamaica Lifestyle Survey conducted from 2000–2001. A sample of 2012 persons, 15–74 years old, completed an interviewer administered questionnaire and had anthropometric and blood pressure measurements performed by trained observers using standardized procedures. Fasting glucose and total cholesterol were measured using a capillary blood sample. Analysis yielded crude, and sex-specific prevalence estimates for prehypertension and other CVD risk factors. Odds ratios for associations of prehypertension with CVD risk factors were obtained using logistic regression.</p> <p>Results</p> <p>The prevalence of prehypertension among Jamaicans was 30% (95% confidence interval [CI] 27%–33%). Prehypertension was more common in males, 35% (CI 31%–39%), than females, 25% (CI 22%–28%). Almost 46% of participants were overweight; 19.7% were obese; 14.6% had hypercholesterolemia; 7.2% had diabetes mellitus and 17.8% smoked cigarettes. With the exception of cigarette smoking and low physical activity, all the CVD risk factors had significantly higher prevalence in the prehypertensive and hypertensive groups (p for trend < 0.001) compared to the normotensive group. Odds of obesity, overweight, high cholesterol and increased waist circumference were significantly higher among younger prehypertensive participants (15–44 years-old) when compared to normotensive young participants, but not among those 45–74 years-old. Among men, being prehypertensive increased the odds of having >/=3 CVD risk factors versus no risk factors almost three-fold (odds ratio [OR] 2.8 [CI 1.1–7.2]) while among women the odds of >/=3 CVD risk factors was increased two-fold (OR 2.0 [CI 1.3–3.8])</p> <p>Conclusion</p> <p>Prehypertension occurs in 30% of Jamaicans and is associated with increased prevalence of other CVD risk factors. Health-care providers should recognize the increased CVD risk of prehypertension and should seek to identify and treat modifiable risk factors in these persons.</p