Tongue Twisting Word Listing

I’m Tall like Bunyan, Pierce, and Gasol,I’m white like Wall, but my names not Paul, unfortunate fortune tellers break their crystal ball,Peter Piper picked a patch, cabbage patch doll,wicked wizardry words slippery like lotion ~excerpt from poe

Made in Criticalland: Designing Matters of Concern

Critical and theoretical concepts and theories are now firmly embedded within design education, but to what goal? How will the practice of design develop and change under the ethos of critical inquiry? Indeed, what version of ‘critique’? Taking inspiration from Latour’s essay 'Why Has Critique Run out of Steam? From Matters of Fact to Matters of Concern (2004), this paper will outline how we are introducing concepts and methods derived from science and technology studies (STS), principally developments in actor-network theory (ANT), as part of the BA and MA design programmes at Goldsmiths. To begin, we provide a brief reading of Latour’s essay, discussing its relevance for design education. In doing so we aim to propose an alternative version of critical practice: a criticality that is oriented towards a non-reductive empirical realism tracing the complex messy entanglements of societies with all their strange, weird and wonderful hybrid objects. At the core of the paper, then, is the question of how designers might adopt a realist empirical approach towards the research of societies, actors and networks, whilst allowing for creative speculation. To address this question we present two case studies to highlight the benefits and shortfalls of an STS and ANT inspired approach to design. The first describes a series of workshops with which we encourage our students to adopt the concepts and methods of STS and ANT as part of their design practice. In the second case study we present a design brief in which we ask students to seriously address fictional futures through the associative mingling of statistical entities. In doing so we are exploring how design can address the mediation of expectations and temporality: how, for example, designers might act with ‘matters of concern’ to prospect futures. Each of the case studies highlights a problematic found within both ANT and Design: the first issue is one of truncation. How, in accepting an empirical logic of connectivity, designers delimited and edit their networks of observation and influence. The second case study focuses on the issue of temporality, or more specifically 'future orientation', 'potential' or 'prospect'. Here, design can be seen as a means of ‘departure’ in the material-semiotic lives of objects

Vascular types I and II transforming growth factor-beta receptor expression: differential dependency on tyrosine kinases during induction by TGF-β

AbstractRecent evidence indicates that the type II transforming growth factor-β (TGF-β) receptor (TβRII) is a serine-threonine-tyrosine kinase. However, the significance of its tyrosine kinase is unclear. We investigated in vascular smooth muscle cells the effects of tyrosine kinase inhibition on the expression of TGF-β receptor types I (ALK-5) and II (TβRII) mRNA, induced by TGF-β1. TGF-β1 elevated ALK-5 mRNA levels 5-fold; essentially similar TGF-β1-dependent elevations were observed with growth factors, PDGF-BB and FGF-2. The tyrosine kinase inhibitor genistein abolished these TGF-β1 and growth factor responses. TGF-β1 also elevated TβRII mRNA levels which were not inhibited by genistein. We conclude that tyrosine kinases participate in defining how cells respond to TGF-β

Determination of Volcanic Impact on Perchlorate Using Polar Ice Cores

Arctic (Greenland) ice core samples covering the time period of 1638-1646 were analyzed for perchlorate and sulfate concentrations. The sulfate data show a signal corresponding to the 1640 eruption of the Komaga-Take volcano in Japan. Perchlorate concentrations show a significant increase at the time of the Komaga-Take eruption. It is concluded that a positive correlation likely exists between stratospheric volcanic eruptions and perchlorate concentration in the environment. When a volcano has enough explosive force to inject substances into the stratosphere, some of the substances, such as sulfate, can remain in the stratosphere for months and spread all over the global atmosphere. The sulfate aerosols in the stratosphere may enhance the formation of perchlorate from chlorine species commonly present in the atmospheric environment