1,422 research outputs found
Characterization of damage in shielding structures of space vehicles under hypervelocity impact
6th Asia Pacific Workshop on Structural Health Monitoring, APWSHM, Hobart, Tasmania, Australia, 7-9 December 2016Version of RecordPublishe
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Grain refinement of Mg-Ca alloys by native MgO particles
Supplementary materials are available online at: https://www.sciencedirect.com/science/article/pii/S2213956724000938?via%3Dihub#sec0012 .In Mg-Ca alloys the grain refining mechanism, in particular regarding the role of nucleant substrates, remains the object of debates. Although native MgO is being recognised as a nucleating substrate accounting for grain refinement of Mg alloys, the possible interactions of MgO with alloying elements that may alter the nucleation potency have not been elucidated yet. Herein, we design casting experiments of Mg-xCa alloys varied qualitatively in number density of native MgO, which are then comprehensively studied by advanced electron microscopy. The results show that grain refinement is enhanced as the particle number density of MgO increases. The native MgO particles are modified by interfacial layers due to the co-segregation of Ca and N solute atoms at the MgO/Mg interface. Using aberration-corrected scanning transmission electron microscopy and electron energy loss spectroscopy, we reveal the nature of these Ca/N interfacial layers at the atomic scale. Irrespective of the crystallographic termination of MgO, Ca and N co-segregate at the MgO/Mg interface and occupy Mg and O sites, respectively, forming an interfacial structure of a few atomic layers. The interfacial structure is slightly expanded, less ordered and defective compared to the MgO matrix due to compositional deviations, whereby the MgO substrate is altered as a poorer template to nucleate Mg solid. Upon solidification in a TP-1 mould, the impotent MgO particles account for the grain refining mechanism, where they are suggested to participate into nucleation and grain initiation processes in an explosive manner. This work not only reveals the atomic engineering of a substrate through interfacial segregation but also demonstrates the effectiveness of a strategy whereby native MgO particles can be harnessed for grain refinement in Mg-Ca alloys.EPSRC is gratefully acknowledged for financial support under grant number EP/N007638/1. The SuperSTEM Laboratory is the UK National Research Facility for Advanced Electron Microscopy, supported by EPSRC under grant number EP/W021080/1. SHW gratefully acknowledges ETC in Brunel University for providing access to the facilities
Segregation of Ca at the Mg/MgO interface and its effect on grain refinement of Mg alloys
It has been reported that native MgO particles in Mg alloy melts can act as heterogeneous nucleation substrates such that grain refinement of Mg alloys is achieved. A recent study showed the addition of Ca, combined with the native MgO particles, significantly improves grain refinement of Mg and its alloys. However, the mechanism underlying the grain refining phenomenon is not well understood due to the lack of direct experimental evidence. In this work, we investigated the segregation of Ca atoms at the Mg/MgO interface and its effect on grain refinement in Mg-0.5Ca alloys by utilizing advanced analytical electron microscopy. The experimental results focus on the chemical and structural information at the interface between MgO and the Ca solute. Adsorption layers rich in Al, N and Ca have been detected on {1 1 1} facets of MgO particles, with the lattice structure resembling the structure of MgO. It is suggested that the significant grain refinement improvement can be attributed not only to the growth restriction due to the presence of Ca addition but also to the specific chemistry and structure of the adsorption layers.EPSRC is gratefully acknowledged for financial support under grant number EP/N007638 /1. The SuperSTEM Laboratory is the U.K National Research Facility for Advanced Electron Microscopy, supported by EPSRC. SHW gratefully acknowledges the China Scholarship Council (CSC) for financial support
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Segregation of Yttrium at the Mg/MgO interface in an Mg-0.5Y Alloy
Supplementary materials are available online at https://www.sciencedirect.com/science/article/pii/S1359645423004780#sec0023 .Copyright © 2023 The Author(s). Interfacial segregation of selected elements can be exploited to manipulate the potency of solid substrates for heterogeneous nucleation, thus controlling the solidification process. As the native inclusions in Mg alloys, MgO acts as the nucleating substrate, but it has rarely been studied in terms of its interactions with alloying elements. In this work, investigations of yttrium (Y) segregation at interfaces between native MgO particles and Mg in an Mg-0.5Y alloy were carried out by state-of-the-art aberration-corrected scanning transmission electron microscopy (STEM) and associated spectroscopy. Experimental results show that native MgO particles in Mg-0.5Y possess two typical morphologies: truncated octahedron primarily faceted by {111}MgO and minorly by {100}MgO, and cubic shape with unique {100}MgO facets. Y atoms are found to segregate at both Mg/{111}MgO and Mg/{100}MgO interfaces, leading to the formation of two different 2-dimensional compounds (2DCs). The 2DC at the Mg/{111}MgO interface is identified as two atomic layers of a face-centered cubic Y2O3 phase in terms of crystal structure and chemistry, whilst it is an Mg(Y)-O monolayer at the Mg/{100}MgO interface, coherently matching with the terminating {100}MgO plane. Discussion is focused on the mechanisms underlying the formation of the 2DCs, their effects on the nucleation potency of MgO particles, and grain refinement. This work sheds light on how heterogeneous nucleation can be manipulated by altering the nucleation potency of a substrate through deliberately promoting elemental segregation of carefully chosen element(s).EPSRC under grant number EP/N007638/1. The SuperSTEM Laboratory is the U.K National Research Facility for Advanced Electron Microscopy, supported by EPSRC under grant number EP/W021080/1. SHW gratefully acknowledges the China Scholarship Council (CSC) for financial support
PI3K mediated activation of GSK‑3β reduces at‑level primary afferent growth responses associated with excitotoxic spinal cord injury dysesthesias
Background
Neuropathic pain and sensory abnormalities are a debilitating secondary consequence of spinal cord injury (SCI). Maladaptive structural plasticity is gaining recognition for its role in contributing to the development of post SCI pain syndromes. We previously demonstrated that excitotoxic induced SCI dysesthesias are associated with enhanced dorsal root ganglia (DRG) neuronal outgrowth. Although glycogen synthase kinase-3β (GSK-3β) is a known intracellular regulator neuronal growth, the potential contribution to primary afferent growth responses following SCI are undefined. We hypothesized that SCI triggers inhibition of GSK-3β signaling resulting in enhanced DRG growth responses, and that PI3K mediated activation of GSK-3β can prevent this growth and the development of at-level pain syndromes.
Results
Excitotoxic SCI using intraspinal quisqualic acid (QUIS) resulted in inhibition of GSK-3β in the superficial spinal cord dorsal horn and adjacent DRG. Double immunofluorescent staining showed that GSK-3βP was expressed in DRG neurons, especially small nociceptive, CGRP and IB4-positive neurons. Intrathecal administration of a potent PI3-kinase inhibitor (LY294002), a known GSK-3β activator, significantly decreased GSK-3βP expression levels in the dorsal horn. QUIS injection resulted in early (3 days) and sustained (14 days) DRG neurite outgrowth of small and subsequently large fibers that was reduced with short term (3 days) administration of LY294002. Furthermore, LY294002 treatment initiated on the date of injury, prevented the development of overgrooming, a spontaneous at-level pain related dysesthesia.
Conclusions
QUIS induced SCI resulted in inhibition of GSK-3β in primary afferents and enhanced at-level DRG intrinsic growth (neurite elongation and initiation). Early PI3K mediated activation of GSK-3β attenuated QUIS-induced DRG neurite outgrowth and prevented the development of at-level dysesthesias.ECU Open Access Publishing Support Fun
A remark on an overdetermined problem in Riemannian Geometry
Let be a Riemannian manifold with a distinguished point and
assume that the geodesic distance from is an isoparametric function.
Let be a bounded domain, with , and consider
the problem in with on ,
where is the -Laplacian of . We prove that if the normal
derivative of along the boundary of is a
function of satisfying suitable conditions, then must be a
geodesic ball. In particular, our result applies to open balls of
equipped with a rotationally symmetric metric of the form
, where is the standard metric of the sphere.Comment: 8 pages. This paper has been written for possible publication in a
special volume dedicated to the conference "Geometric Properties for
Parabolic and Elliptic PDE's. 4th Italian-Japanese Workshop", organized in
Palinuro in May 201
Fabrication of silicon-on-reflector for Si-based resonant-cavity-enhanced photodetectors
A novel silicon-on-reflector substrate for Si-based resonant-cavity-enhanced photodetectors has been fabricated by using Si-based sol-gel and smart-cut techniques. The Si/SiO2 Bragg reflector is controlled in situ by electron beam evaporation and the thickness can be adjusted to get high reflectivity. The reflectance spectra of the silicon-on-reflector substrate with five pairs of Si/SiO2 reflector have been measured and simulated by transfer matrix model. The reflectivity at operating wavelength is close to 100%. Based on the silicon-on-reflector substrate, SiGe/Si multiple quantum wells resonant-cavity-enhanced photodetectors for 1.3 mu m wavelength have been designed and simulated. Ten-fold enhancement of the quantum efficiency of resonant-cavity-enhanced photodetectors compared with conventional photodetectors is predicted
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