Updating Bounds on RR-Parity Violating Supersymmetry from Meson Oscillation Data

We update the bounds on $R$-parity violating supersymmetry originating from meson oscillations in the $B^0_{d/s}$ and $K^0$ systems. To this end, we explicitly calculate all corresponding contributions from $R$-parity violating operators at the one-loop level, thereby completing and correcting existing calculations. We apply our results to the derivation of bounds on $R$-parity violating couplings, based on up-to-date experimental measurements. In addition, we consider the possibility of cancellations among flavor-changing contributions of various origins, e.g. from multiple $R$-parity violating couplings or $R$-parity conserving soft terms. Destructive interferences among new-physics contributions could then open phenomenologically allowed regions, for values of the parameters that are naively excluded when the parameters are varied individually.Comment: 53 pages, 10 figures, 2 tables; final versio

Vehicle Routing under Consideration of Transhipment in Horizontal Coalitions of Freight Carriers

AbstractIn order to reduce operational costs related to transportation activities in road haulage, small and medium-sized freight carriers can establish horizontal coalitions and share their resources. Through exchange of customer requests with other members within the coalition, carriers can improve the operational efficiency of their transportation processes. In this paper, transhipment is integrated into the conventional pickup and delivery problem in the collaborative context. Specifically, vehicles involved in transferring the same request are synchronized at the transhipment points. A mixed-integer programming model is proposed for this problem. Based on this model the benefits of transhipment are analysed. Computational results show considerable cost-savings enabled by transhipment in the operational planning of carrier coalitions

Propagation model for the dynamics of gain‐guided semiconductor laser arrays

A model is presented for the spatiotemporal dynamics of gain‐guided semiconductor laser arrays. The model goes beyond coupled mode theory and treats the array as a single entity. Numerical simulations of twin‐stripe gain‐guided arrays yield stable or pulsing outputs, depending on array parameters.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/70023/2/JAPIAU-73-1-462-1.pd

Fractal Landscapes in Policy Optimization

Policy gradient lies at the core of deep reinforcement learning (RL) in continuous domains. Despite much success, it is often observed in practice that RL training with policy gradient can fail for many reasons, even on standard control problems with known solutions. We propose a framework for understanding one inherent limitation of the policy gradient approach: the optimization landscape in the policy space can be extremely non-smooth or fractal for certain classes of MDPs, such that there does not exist gradient to be estimated in the first place. We draw on techniques from chaos theory and non-smooth analysis, and analyze the maximal Lyapunov exponents and H\"older exponents of the policy optimization objectives. Moreover, we develop a practical method that can estimate the local smoothness of objective function from samples to identify when the training process has encountered fractal landscapes. We show experiments to illustrate how some failure cases of policy optimization can be explained by such fractal landscapes.Comment: 18 pages and 28 figure

The role of TMPRSS6/matriptase-2 in iron regulation and anemia

Matriptase-2, encoded by the TMPRSS6 gene, is a member of the type II transmembrane serine protease family. Matriptase-2 has structural and enzymatic similarities to matriptase-1, which has been implicated in cancer progression. Matriptase-2 was later established to be essential in iron homeostasis based on the phenotypes of iron-refractory iron deficiency anemia identified in mouse models as well as in human patients with TMPRSS6 mutations. TMPRSS6 is expressed mainly in the liver and negatively regulates the production of hepcidin, the systemic iron regulatory hormone. This review focuses on the current understanding of matriptase-2 biochemistry, and its role in iron metabolism and cancer progression. In light of recent investigations, the function of matriptase-2 in hepcidin regulation, how it is being regulated, as well as the therapeutic potential of matriptase-2 are also discussed

Measurement and simulation of anisotropic magnetoresistance in single GaAs/MnAs core/shell nanowires

We report four probe measurements of the low field magnetoresistance in single core/shell GaAs/MnAs nanowires synthesized by molecular beam epitaxy, demonstrating clear signatures of anisotropic magnetoresistance that track the field-dependent magnetization. A comparison with micromagnetic simulations reveals that the principal characteristics of the magnetoresistance data can be unambiguously attributed to the nanowire segments with a zinc blende GaAs core. The direct correlation between magnetoresistance, magnetization and crystal structure provides a powerful means of characterizing individual hybrid ferromagnet/semiconductor nanostructures.Comment: Submitted to Applied Physics Letters; some typos corrected and a defective figure replace

Relative reactivities of alkenes toward the diphenylmethyl cation

The relative reactivities of alkyl and phenyl substituted alkenes toward diphenylmethyl chloride/ZnCl2/Et2O in dichloromethane at −78°C have been determined by competition experiments. The transition state structure is discussed