14,256 research outputs found
Transport and Loss of Ring Current Electrons Inside Geosynchronous Orbit During the 17 March 2013 Storm.
Ring current electrons (1-100 keV) have received significant attention in recent decades, but many questions regarding their major transport and loss mechanisms remain open. In this study, we use the four-dimensional Versatile Electron Radiation Belt code to model the enhancement of phase space density that occurred during the 17 March 2013 storm. Our model includes global convection, radial diffusion, and scattering into the Earth's atmosphere driven by whistler-mode hiss and chorus waves. We study the sensitivity of the model to the boundary conditions, global electric field, the electric field associated with subauroral polarization streams, electron loss rates, and radial diffusion coefficients. The results of the code are almost insensitive to the model parameters above 4.5 R E R E, which indicates that the general dynamics of the electrons between 4.5 R E and the geostationary orbit can be explained by global convection. We found that the major discrepancies between the model and data can stem from the inaccurate electric field model and uncertainties in lifetimes. We show that additional mechanisms that are responsible for radial transport are required to explain the dynamics of ≥40-keV electrons, and the inclusion of the radial diffusion rates that are typically assumed in radiation belt studies leads to a better agreement with the data. The overall effect of subauroral polarization streams on the electron phase space density profiles seems to be smaller than the uncertainties in other input parameters. This study is an initial step toward understanding the dynamics of these particles inside the geostationary orbit
Asymmetric long period fiber gratings fabricated by use of CO₂laser to carve periodic grooves on the optical fiber
Author name used in this publication: Peng, Gang-DingAuthor name used in this publication: Wang, Yi-Ping2006-2007 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe
Glucagon-Like Peptide-1 Modulates Neurally-Evoked Mucosal Chloride Secretion in Guinea Pig Small Intestine In Vitro.
Glucagon-like peptide-1 (GLP-1)
acts at the G protein-coupled receptor, GLP-1R, to stimulate secretion
of insulin and to inhibit secretion of glucagon and gastric acid.
Involvement in mucosal secretory physiology has received negligible
attention. We aimed to study involvement of GLP-1 in mucosal
chloride secretion in the small intestine. Ussing chamber methods, in
concert with transmural electrical field stimulation (EFS), were used
to study actions on neurogenic chloride secretion. ELISA was used to
study GLP-1R effects on neural release of acetylcholine (ACh).
Intramural localization of GLP-1R was assessed with immunohistochemistry.
Application of GLP-1 to serosal or mucosal sides of
flat-sheet preparations in Ussing chambers did not change baseline
short-circuit current (Isc), which served as a marker for chloride
secretion. Transmural EFS evoked neurally mediated biphasic increases
in Isc that had an initial spike-like rising phase followed by a
sustained plateau-like phase. Blockade of the EFS-evoked responses
by tetrodotoxin indicated that the responses were neurally mediated.
Application of GLP-1 reduced the EFS-evoked biphasic responses in
a concentration-dependent manner. The GLP-1 receptor antagonist
exendin-(9 –39) suppressed this action of GLP-1. The GLP-1 inhibitory
action on EFS-evoked responses persisted in the presence of
nicotinic or vasoactive intestinal peptide receptor antagonists but not
in the presence of a muscarinic receptor antagonist. GLP-1 significantly
reduced EFS-evoked ACh release. In the submucosal plexus,
GLP-1R immunoreactivity (IR) was expressed by choline acetyltransferase-
IR neurons, neuropeptide Y-IR neurons, somatostatin-IR neurons,
and vasoactive intestinal peptide-IR neurons. Our results suggest
that GLP-1R is expressed in guinea pig submucosal neurons and that
its activation leads to a decrease in neurally evoked chloride secretion
by suppressing release of ACh at neuroepithelial junctions in the
enteric neural networks that control secretomotor functions
Inscription of polymer optical fiber Bragg grating at 962 nm and its potential in strain sensing
Author name used in this publication: Zhi Feng ZhangAuthor name used in this publication: Xiao Ming TaoAuthor name used in this publication: Guang Feng Wang2010-2011 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe
Excitation Dependent Phosphorous Property and New Model of the Structured Green Luminescence in ZnO
published_or_final_versio
Enhanced broadband near-IR luminescence and gain spectra of bismuth/erbium co-doped fiber by 830 and 980 nm dual pumping
© 2017 Author(s). A dual 830 and 980 nm pumping scheme is proposed aiming at broadening and flattening the spectral performance of bismuth/erbium codoped multicomponent fiber (BEDF). The spectral properties of distinct Bi active centers (BACs) associated with germanium (BAC-Ge), aluminium (BAC-Al), phosphorus (BAC-P) and silicon (BAC-Si) are characterized under single pumping of 830 and 980 nm, respectively. Based on the emission slope efficiencies of BAC-Al (∼1100 nm) and BAC-Si (∼1430 nm) under single pumping of 830 and 980 nm, the dual pumping scheme with the optimal pump power ratio of 25 (980 nm VS 830 nm) is determined to achieve flat, ultrabroadband luminescence spectra covering the wavelength range 950-1600 nm. The dual pumping scheme is further demonstrated on the on-off gain performance of BEDF. It is found under the pump power ratio of ∼8 (980 VS 830 nm), The gain spectrum has been flattened and broadened over 300 nm (1300-1600 nm) with an average gain coefficient of ∼1.5 dBm-1. The spectral coverage is approximately 1.5 and 3 times wider compared to single pumping of 830 and 980 nm pumping, respectively. The energy level diagrams of 830 and 980 nm are also constructed separately in view of the optical characteristic, which further clarifies the advantage for dual pumping. The proposed dual 830 and 980 nm pumping scheme with the multicomponent BEDF shows great potential in various broadband optical applications such as uniform ASE source, broadband amplifier and tuneable laser in NIR band
Automatic alignment of surgical videos using kinematic data
Over the past one hundred years, the classic teaching methodology of "see
one, do one, teach one" has governed the surgical education systems worldwide.
With the advent of Operation Room 2.0, recording video, kinematic and many
other types of data during the surgery became an easy task, thus allowing
artificial intelligence systems to be deployed and used in surgical and medical
practice. Recently, surgical videos has been shown to provide a structure for
peer coaching enabling novice trainees to learn from experienced surgeons by
replaying those videos. However, the high inter-operator variability in
surgical gesture duration and execution renders learning from comparing novice
to expert surgical videos a very difficult task. In this paper, we propose a
novel technique to align multiple videos based on the alignment of their
corresponding kinematic multivariate time series data. By leveraging the
Dynamic Time Warping measure, our algorithm synchronizes a set of videos in
order to show the same gesture being performed at different speed. We believe
that the proposed approach is a valuable addition to the existing learning
tools for surgery.Comment: Accepted at AIME 201
Synthesis and characterization of folate-poly(ethylene glycol) chitosan graft-polyethylenimine as a non-viral carrier for tumor-targeted gene delivery
The use of chitosan and chitosan derivatives for gene delivery is limited due to the low transfection efficiency and difficulty in transfecting into a variety of cell types, including some cancer cells overexpressing folate receptor (FRs). In order to solve this problem, folate (FA) and poly(ethylene glycol) (PEG) was conjugated to chitosan-graft-polyethylenimine (CHI-g-PEI) to enhance water-solubility and the transfection efficiency. In the present study, a cell specific targeting molecule FA was linked on PEG and then grafted the FA-PEG onto CHI-g-PEI. The FA-PEG-grafted CHI-g-PEI (FA-PEG-CHI-g-PEI) effectively condensed the plasmid DNA (pDNA) into nanoparticles with positive surface charge under the suitable nitrogen/phosphorus (N/P) ratio. In vitro, transfection efficiency of the FA-PEG-CHI-g-PEI /pDNA complex in 293T cells and LoVo cells (FRs over-expressing cell lines) increased with increasing N/P ratio under N/P = 15 and was more than 50%, but no significant difference in human lung carcinoma cells (A549) cells (FRs deficient cell lines). Importantly, in vivo luciferase expression showed that the efficiency of FA-PEG-CHI-g-PEI -mediated transfection (50 μg luciferase plasmid (pLuc), N/P ratio = 15) was comparable to that of adenovirus-mediated luciferase transduction (1 × 109 pfu) in melanomabearing mice. It was concluded that FA-PEG-CHI-g-PEI, which has improved transfection efficiency and FRs specificity in vitro and in vivo, may be useful in gene therapy.Key words: Folate poly(ethylene glycol)-chitosan-grafted-polyethylenimine (FA-PEG-CHI-g-PEI), gene transfection, non-virus vector, in vitro, in viv
Foraminiferal biostratigraphy and palaeoenvironmental analysis of the mid-Cretaceous limestones in the southern Tibetan plateau
This study of mid-Cretaceous foraminifera from the Linzhou, the Coqen and the Xigaze Basins in the southern Tibetan Plateau has provided the first high resolution biostratigraphic description of these limestones and interpretation of their paleoenvironmental settings. The fossil assemblages are dominated primarily by orbitolinid larger benthic foraminifera. We reassessed the identification of many taxa, dividing the South Tibetan sedimentary successions of Aptian to Early Cenomanian age into eight new foraminiferal biozones (TLK1 a–h): (i) (TLK1a) a shallow reefal environment corresponding to planktonic foraminifera zone (PZ) Aptian 1–2, dominated by Palorbitolina and Praeorbitolina spp.; (ii) (TLK1b) a transgressive, reefal to forereefal environment corresponding to PZ Aptian 3, characterized by the first appearance of Mesorbitolina parva; (iii) (TLK1c) a shallow reefal to backreef environment of Late Aptian (PZ Aptian 4) age, characterized by the first appearance of Mesorbitolina texana; (iv) (TLK1d) a transgressive phase of forereef to an inner neritic environment of Albian (PZ Albian 1) age, characterized by the first appearance of Cuneolina pavonia; (v) (TLKe) an open-marine reefal environment of Albian (PZ Albian 2) age, with assemblages dominated by flat to slightly conical orbitolinids, characterized by the first appearance of Palorbitolinoides hedini; (vi) (TLK1f) a shallow, open-marine reefal to forereef environment of Middle Albian (PZ Albian 3) age, dominated by flat and convex orbitolinids, and characterized by the first appearance of Mesorbitolina aperta; (vii) (TLK1g) a reefal to forereef environment of end Albian (PZ Albian 4) age, characterized by the appearance of Conicorbitolina cf. cuvillieri and Pseudochoffatella cuvillieri, and in which Early Aptian species of Praeorbitolina cf. wienandsi have been recorded for the first time from the Late Albian; (viii) (TLK1h) a shallow reefal environment of Early Cenomanian age characterized by the first appearance of Conicorbitolina sp. A and Nezzazata conica. The eight new biozones provided biostratigraphic correlation of the Langshan, Sangzugang and Takena Formations in the Lhasa terrane, while the observed evolution of the environmentally controlled microfacies corresponds closely with the current, inferred global sea-level variation of the period. The almost continuous sedimentary sequences studied allowed previously defined orbitolinid phylogenetic linages to be confirmed
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