Vortex signal detection method with stochastic resonance based on adaptive coupled feedback control

The control of stochastic resonance is the key to its application. A feedback method is proposed to control the generation of stochastic resonance with coupling, and then enhance resonance effect with the optimization of control parameters. The method is applied to detect vortex signal. Artificial fish swarm algorithm is used to adjust the control variables adaptively, thus the optimal control of the coupled bistable stochastic resonance is realized. Numerical simulation and experimental results manifest that by this means the resonance effect can be enhanced effectively, the signal-to-noise ratio (SNR) of vortex signal can be improved, and the vortex shedding frequency can be obtained accurately

Ion channel gene GJB2 influences the intercellular communication by Up-regulating the SPP1 signaling pathway identified by the single-cell RNA sequencing in lung adenocarcinoma

ObjectiveFirstly, observe the prognostic significance and the biological functional effects of gap junction protein beta 2 (GJB2 or Cx26) in lung adenocarcinoma (LUAD). Subsequently, explore the role played by GJB2 in intercellular communication by single-cell RNA sequencing.MethodWe made a differential analysis of GJB2 expression through public databases and investigated the clinical characteristics and prognostic significance. ESTIMATE analysis and Tumor Immune Estimation Resource (TIMER) database were utilized to illustrate the association of GJB2 with immune infiltration and components of the tumor microenvironment. Gene Ontology (GO), Kyoto encyclopedia of genes and genomes (KEGG), and Gene set enrichment analysis (GSEA) were performed to study the biological function of GJB2. Cell-cell communication was analyzed using the CellChat R package through sc-RNA data.ResultsGJB2 has an outstanding prognosis value in LUAD and a close relationship was found between GJB2 and immune infiltration in LUAD. GJB2 could participate in several tumor biological processes, including extracellular matrix remodeling and upregulation of multiple cancer-related active pathways. GJB2 related hub-genes influence intercellular communication through the SPP1 signaling pathway.ConclusionOur study illustrates one mechanism by which GJB2 exerts its cancer-specific relevant effects, that is, causing changes in intercellular communication through the SPP1 signaling pathway. Blockade of this pathway may limit the functional role of GJB2 and provide us with promising new perceptions for LUAD treatment

Concomitant mutation status of ALK-rearranged non-small cell lung cancers and its prognostic impact on patients treated with crizotinib

Background: In non-small cell lung cancer (NSCLC), anaplastic lymphoma kinase (ALK) rearrangement characterizes a subgroup of patients who show sensitivity to ALK tyrosine kinase inhibitors (TKIs). However, the prognoses of these patients are heterogeneous. A better understanding of the genomic alterations occurring in these tumors could explain the prognostic heterogeneity observed in these patients. Methods: We retrospectively analyzed 96 patients with NSCLC with ALK detected by immunohistochemical staining (VENTANA anti-ALK(D5F3) Rabbit Monoclonal Primary Antibody). Cancer tissues were subjected to next-generation sequencing using a panel of 520 cancer-related genes. The genomic landscape, distribution of ALK fusion variants, and clinicopathological characteristics of the patients were evaluated. The correlations of genomic alterations with clinical outcomes were also assessed. Results: Among the 96 patients with immunohistochemically identified ALK fusions, 80 (83%) were confirmed by next-generation sequencing. TP53 mutation was the most commonly co-occurring mutation with ALK rearrangement. Concomitant driver mutations [2 Kirsten rat sarcoma viral oncogene homolog (KRAS) G12, 1 epidermal growth factor receptor (EGFR) 19del, and 1 MET exon 14 skipping] were also observed in 4 adenocarcinomas. Echinoderm microtubule associated protein-like 4 (EML4)-ALK fusions were identified in 95% of ALK-rearranged patients, with 16.2% of them also harboring additional non-EML4- ALK fusions. Nineteen non-EML4 translocation partners were also discovered, including 10 novel ones. Survival analyses revealed that patients concurrently harboring PIK3R2 alterations showed a trend toward shorter progression-free survival (6 vs. 13 months, P=0.064) and significantly shorter overall survival (11 vs. 32 months, P=0.004) than did PIK3R2-wild-type patients. Patients with concomitant alterations in PI3K the signaling pathway also had a shorter median overall survival than those without such alterations (23 vs. 32 months, P=0.014), whereas progression-free survival did not differ significantly. Conclusions: The spectrum of ALK-fusion variants and the landscape of concomitant genomic alterations were delineated in 96 NSCLC patients. Our study also demonstrated the prognostic value of concomitant alterations in crizotinib-treated patients, which could facilitate improved stratification of ALK-rearranged NSCLC patients in the selection of candidates who could optimally benefit from therapy

Nine radiation components observed at the Shangdianzi regional GAW station in China (2013-2022)

This dataset consists of quality-assured daily data of nine radiation components (i.e., global shortwave irradiance, direct shortwave irradiance, diffuse shortwave irradiance, upwelling shortwave irradiance, photosyntheticall active radiation, ultraviolet A irradiance, ultraviolet B irradiance, downwelling longwave irradiance, and upwelling longwave irradiance) observed at the Shangdianzi regional GAW station (40.65°N, 117.12°E; 293.3 m a.s.l.) in China during 2013–2022. A Hybrid Algorithm for Radiation Data Quality Control (HARDQC) algorithm is performed on all radiation data to guarantee the highest quality of the dataset. The dataset can be applied in many fields such as the validation of satellite products and numerical models, investigation of relationships between radiation and atmospheric composition, and the detection of changes in the surface fluxes

Identification of preoperative prediction factors of tumor subtypes for patients with solitary ground-glass opacity pulmonary nodules

Abstract Background Recent wide spread use of low-dose helical computed tomography for the screening of lung cancer have led to an increase in the detection rate of very faint and smaller lesions known as ground-glass opacity nodules. The purpose of this study was to investigate the clinical factors of lung cancer patients with solitary ground-glass opacity pulmonary nodules on computed tomography. Methods A total of 423 resected solitary ground-glass opacity nodules were retrospectively evaluated. We analyzed the clinical, imaging and pathological data and investigated the clinical differences in patient with adenocarcinoma in situ / minimally invasive adenocarcinoma and those with invasive adenocarcinoma. Results Three hundred and ninety-three adenocarcinomas (92.9%) and 30 benign nodules were diagnosed. Age, the history of family cancer, serum carcinoembryonic antigen level, tumor size, ground-glass opacity types, and bubble-like sign in chest CT differed significantly between adenocarcinoma in situ / minimally invasive adenocarcinoma and invasive adenocarcinoma (p:0.008, 0.046, 0.000, 0.000, 0.000 and 0.001). Receiver operating characteristic curves and univariate analysis revealed that patients with more than 58.5 years, a serum carcinoembryonic antigen level > 1.970 μg/L, a tumor size> 13.50 mm, mixed ground-glass opacity nodules and a bubble-like sign were more likely to be diagnosed as invasive adenocarcinoma. The combination of five factors above had an area under the curve of 0.91, with a sensitivity of 82% and a specificity of 87%. Conclusion The five-factor combination helps us to distinguish adenocarcinoma in situ / minimally invasive adenocarcinoma from invasive adenocarcinoma and to perform appropriate surgery for solitory ground-glass opacity nodules

Internal Flow Field and Loss Analysis of a Magnetic Drive Pump’s Cooling Circuit

The cooling circuit is an important component of the magnetic drive pump because it prevents demagnetization of the permanent magnet and damage to the containment shell owing to a high temperature increase. In this paper, the flow field and losses of the cooling circuit of the magnetic pump are discussed and experimentally verified based on numerical simulation methods. Five different lengths of magnetic couplings were designed, and the flow field distribution, cooling flow rate, and loss variation laws of the cooling circuit were analyzed. The results show that the pump flow rate and magnetic coupling length have a minimal effect on the velocity distribution in the cooling circuit. When the magnet length increases from 30 mm to 55 mm, the temperature rise of the cooling circuit and the pressure drop at the gap increase by 23.1% and 25.3%, respectively. When the length of the magnetic coupling remains constant, the cooling flow rate of the cooling circuit falls with an increasing pump flow rate, and it reduces by 8.4% when the pump flow rate increases from 0.7 Q to 1.3 Q. The water friction loss and eddy current loss of the cooling circuit increase with an increase in the magnetic coupling length, while the cooling flow rate decreases. When the magnet length increases from 30 mm to 55 mm, the eddy current losses in the coupling circuit and the water friction losses in the cooling circuit increase by 45% and 35%, respectively, while the cooling flow rate decreases by 13%

Real-Time <i>Ab Initio</i> Investigation on Hot Electron Relaxation Dynamics in Silicon

The relaxation of hot electrons in semiconductors is pivotal for both energy harvesting processes and optoelectronics. Utilizing a self-developed non-adiabatic molecular dynamics simulation approach in the momentum space (NAMD_k), we have examined the dynamics of hot electrons in silicon. Whether excited from the Γ or L point, the relaxation dynamics exhibit two distinct stages. Initially, within 100 fs, electrons scatter with phonons throughout the Brillouin zone. Subsequently, over a few picoseconds, they further relax toward the conduction band minimum as a whole. This picture of hot electron relaxation is highly consistent with the quasi-equilibrium hot electron ensemble (HEE) concept. Throughout the hot electron relaxation process, energy transfer to phonons is efficient, leading to time-dependent phonon excitation, which is thoroughly analyzed. This investigation provides a novel perspective on hot electron relaxation in silicon, which holds substantive implications for the realm of photovoltaic and optoelectronic device applications

Facile Preparation of Rod-like MnO Nanomixtures via Hydrothermal Approach and Highly Efficient Removal of Methylene Blue for Wastewater Treatment

In the present study, nanoscale rod-shaped manganese oxide (MnO) mixtures were successfully prepared from graphitic carbon nitride (C3N4) and potassium permanganate (KMnO4) through a hydrothermal method. The as-prepared MnO nanomixtures exhibited high activity in the adsorption and degradation of methylene blue (MB). The as-synthesized products were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), surface area analysis, X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS). Furthermore, the effects of the dose of MnO nanomixtures, pH of the solution, initial concentration of MB, and the temperature of MB removal in dye adsorption and degradation experiments was investigated. The degradation mechanism of MB upon treatment with MnO nanomixtures and H2O2 was studied and discussed. The results showed that a maximum adsorption capacity of 154 mg g&minus;1 was obtained for a 60 mg L&minus;1 MB solution at pH 9.0 and 25 &deg;C, and the highest MB degradation ratio reached 99.8% under the following optimum conditions: 50 mL of MB solution (20 mg L&minus;1) at room temperature and pH &asymp; 8.0 with 7 mg of C, N-doped MnO and 0.5 mL of H2O2