A case of the application of Paxlovid for a patient infected by the SARS-CoV-2 Omicron variant

Coronavirus disease 2019 (COVID-19) is a new acute respiratory infectious disease with high infectivity. To date, > 500 million cases of COVID-19 have been confirmed worldwide (World Health Organization). The Omicron variant has affected nearly every country worldwide due to its high infectivity and immune evasion, which has caused widespread anxiety. However, most of the existing treatments do not effectively reduce the risk of progression to more severe disease, or the existing treatments are too costly or not suitable for extensive use.Paxlovid is a novel oral antiviral drug that has proven effective against symptomatic COVID-19 infection by reducing the risk of progression to severe disease, hospitalization, and mortality

Dark solitons manipulation using optical event horizon

We demonstrate that the optical event horizon can provide an effective technique to actively control the propagation properties of a dark soliton with another weak probe wave. Careful power adjustment of the probe wave enables the black soliton converted into a gray one with varying grayness through the nonlinear interaction, corresponding to a nearly adiabatic variation of the soliton’s speed. The sign of the phase angle for the newly formed gray soliton at optical event horizon is significantly dependent on the frequency of the launched probe wave. Linear-stability analysis of dark solitons under the perturbation of a weak probe wave is performed to clarify the intrinsic mechanism of the nonlinear interaction. The probe wave manipulated collisional dynamics between both dark solitons are investigated as an analogue of the combined white-hole and black-hole horizons which provides some insights into exploring the transition between integrable and non-integrable systems

Active control of adiabatic soliton fission by external dispersive wave at optical event horizon

We show that the group-velocity-led optical event horizon (OEH) in optical fibers provides a convenient way to actively control the propagation property of higher-order solitons by a comparatively weak dispersive wave (DW) pulse. It has been found numerically that clean soliton breakup, a process by which a second-order soliton completely splits into a pair of constituent solitons with vastly different power proportions after interacting with the weak DW pulse, will occur while external DWs become polychromatic. The temporal separation between both constituent solitons can be controlled by adjusting the power of the external DW. The more energetic main soliton is advanced/trailed in time depending on the selected frequency of input DW pulse. We have developed an analytic formalism describing the external acting-force (AF) perturbation. These results provide a fundamental explanation and physical scaling of optical pulse evolution in optical fibers and can find applications in improved supercontinuum sources

Environmental Factors Influencing the Durability of Concrete Structures in Maine Environments

Concrete structures built in marine environment may suffer serious durability problems. Focusing on the reaction between concrete materials and environmental conditions on structural durability, the coefficients of environmental temperature and chloride content are established. Referring to only experimental data tested following the procedure similar to the regulations in NT Build 443(Concrete, Hardened: Accelerated Chloride Penetration) of North Europe, the relationship between D28 and water/binder ratio, which are converted into equivalent values of a standard reference environmental condition at 20ºC and a concentration of 165 g ± 1 g NaCl per dm3 solution, using the established formula of coefficients of environmental temperature and chloride content, is presented. The converted results of different environmental conditions at laboratory and natural environment have a good agreement with each other, which indicates that the coefficients of environmental temperature and chloride content are reasonably determined. The ratio of wetting time per-period defined as the time proportion of concrete in wet conditions to the whole time period can be used to describe the dry-wet conditions in concrete. Analysis on the in-situ detected results shows that the penetration of chloride, the accumulation of surface chloride concentration and the decay of chloride diffusion coefficient are all related to the ratio of wetting time per-period. Subsequently, the formula of apparent chloride diffusion coefficient is proposed with consideration of surrounding temperature, sodium chloride solution concentration, age factor and altitude

Environmental and economic dispatching strategy for power system with the complementary combination of wind-solar-hydro-thermal-storage multiple sources

The linkage, coordination, and complementary cooperation of energy supply can improve the efficiency of transportation and utilization. At present, the level of new energy consumption needs to be improved, the coordination of the source network load storage link is insufficient, and the insufficient complementarity of various types of power sources in the power system. This article fully explores the differences and complementarities of various types of wind-solar-hydro-thermal-storage power sources, a hierarchical environmental and economic dispatch model for the power system has been established. Among them, the upper level model takes the flexible consumption of new energy as the optimization goal, the middle level model uses a combination of hydropower station and energy storage to minimizes the fluctuation variance and peak-to-valley difference of the net load curve, the lower level model aims to achieve optimal environmental and economic benefits of the power system, comprehensively considers the coal consumption cost, startup and shutdown cost, energy storage operation cost, and pollutant emissions of thermal power units, determines the startup and shutdown mode and output power of thermal power units. Finally, an improved IEEE 6-machine 30-node system is used as an example for simulation analysis, the results show that after applying the proposed hierarchical environmental and economic dispatch strategy of the power system, the fluctuation variance and the peak-to-valley difference of the net load curve have been reduced by 46.3% and 31.5%, respectively, and the environmental and economic benefits of the system is improved by 5.1% compared with the traditional economic dispatch strategy. It can meet the requirements of energy system cleaning and decarbonization while improving the operation economy, which verifies the effectiveness of the proposed environmental economic dispatch model

Low-Cost and Real-Time Industrial Human Action Recognitions Based on Large-Scale Foundation Models

Industrial managements, including quality control, cost and safety optimization, etc., heavily rely on high quality industrial human action recognitions (IHARs) which were hard to be implemented in large-scale industrial scenes due to their high costs and poor real-time performance. In this paper, we proposed a large-scale foundation model(LSFM)-based IHAR method, wherein various LSFMs and lightweight methods were jointly used, for the first time, to fulfill low-cost dataset establishment and real-time IHARs. Comprehensive tests on in-situ large-scale industrial manufacturing lines elucidated that the proposed method realized great reduction on employment costs, superior real-time performance, and satisfactory accuracy and generalization capabilities, indicating its great potential as a backbone IHAR method, especially for large-scale industrial applications

Subclavian steal syndrome associated with right aortic arch: A case report

The right aortic arch (RAA) is a rare congenital vascular variant disease. We reported a case of subclavian steal syndrome associated with RAA. The primary clinical symptoms were vertigo and ischemic symptoms of the left upper extremity. We diagnosed the condition using aortic computed tomography angiography and digital subtraction angiography. The patient underwent carotid-subclavian bypass surgery