Presleep focusing on positive spontaneous thoughts enhanced the possibility of dreaming of them

IntroductionDreaming is the subjective experience during sleep. A spontaneous thought is a thought that comes to one’s mind involuntarily. This study investigated whether presleep focusing on a positive spontaneous thought enhanced the possibility of dreaming of the thought.MethodsNinety-seven participants were quasi-randomly assigned to an expression condition (focus on an spontaneous thought for 5-Min before sleeping; N = 45) and a control condition (think about anything for 5-Min before sleeping; N = 45). Participants completed a dream diary upon waking. Then, both participants themselves (the selfrating method) and external judges (the external-rating method) rated the correlation between the positive spontaneous thought and the dream.ResultsThe result of the external-rating method indicated that presleep focusing on positive spontaneous thoughts enhanced the possibility of dreaming of the thoughts. In addition, the external-rating method found that presleep focusing on positive spontaneous thoughts enhanced the possibility of dreaming of thoughts that were related to the positive spontaneous thoughts but not the positive spontaneous thoughts themselves.DiscussionThese results supported the current concern theory which suggests that one’s current concerns increase responses to cues related to the concerns implicitly. In addition, these results supported the continuity hypothesis which states that dreaming is in continuous with waking life, and thus the intensity of a daily concern may be related to the possibility of dreaming of the daily concern

X-Band Active Phased Array Antenna Using Dual-Port Waveguide for High-Power Microwave Applications

An X-band active phased array horn antenna with high power capacity and high peak power is proposed in this paper. At the horn aperture, the baffles are loaded to suppress higher-order modes and eliminate blind spots during beam scanning. Straight walls are added to improve impedance matching. Considering that the peak power that T/R modules can provide is very limited, the proposal of a dual-port waveguide breaks through the bottleneck of the power capacity of a single-port input for the first time. The proposed curved dual-port waveguide is used to connect the horn antenna and the T/R module, which is verified to improve the power capacity of the overall internal structure. Simulated and measured results show that VSWR ≤ 2 in the frequency range of 7.5–8.5 GHz. There is no grating lobe in the ±10° scanning range and the maximum gain drop does not exceed 0.4 dB. The power capacity of the proposed HPM array is 56.34 MW. The phased array antenna has the characteristics of flexible scanning, small size, and high gain, and can be applied in high-power microwave systems

Data_Sheet_1_Presleep focusing on positive spontaneous thoughts enhanced the possibility of dreaming of them.docx

IntroductionDreaming is the subjective experience during sleep. A spontaneous thought is a thought that comes to one’s mind involuntarily. This study investigated whether presleep focusing on a positive spontaneous thought enhanced the possibility of dreaming of the thought.MethodsNinety-seven participants were quasi-randomly assigned to an expression condition (focus on an spontaneous thought for 5-Min before sleeping; N = 45) and a control condition (think about anything for 5-Min before sleeping; N = 45). Participants completed a dream diary upon waking. Then, both participants themselves (the selfrating method) and external judges (the external-rating method) rated the correlation between the positive spontaneous thought and the dream.ResultsThe result of the external-rating method indicated that presleep focusing on positive spontaneous thoughts enhanced the possibility of dreaming of the thoughts. In addition, the external-rating method found that presleep focusing on positive spontaneous thoughts enhanced the possibility of dreaming of thoughts that were related to the positive spontaneous thoughts but not the positive spontaneous thoughts themselves.DiscussionThese results supported the current concern theory which suggests that one’s current concerns increase responses to cues related to the concerns implicitly. In addition, these results supported the continuity hypothesis which states that dreaming is in continuous with waking life, and thus the intensity of a daily concern may be related to the possibility of dreaming of the daily concern.</p

Amniotes co-opt intrinsic genetic instability to protect germ-line genome integrity

Unlike PIWI-interacting RNA (piRNA) in other species that mostly target transposable elements (TEs), &gt;80% of piRNAs in adult mammalian testes lack obvious targets. However, mammalian piRNA sequences and piRNA-producing loci evolve more rapidly than the rest of the genome for unknown reasons. Here, through comparative studies of chickens, ducks, mice, and humans, as well as long-read nanopore sequencing on diverse chicken breeds, we find that piRNA loci across amniotes experience: (1) a high local mutation rate of structural variations (SVs, mutations ≥ 50&nbsp;bp in size); (2) positive selection to suppress young and actively mobilizing TEs commencing at the pachytene stage of meiosis during germ cell development; and (3) negative selection to purge deleterious SV hotspots. Our results indicate that genetic instability at pachytene piRNA loci, while producing certain pathogenic SVs, also protects genome integrity against TE mobilization by driving the formation of rapid-evolving piRNA sequences

Clonal associations between lymphocyte subsets and functional states in rheumatoid arthritis synovium

Rheumatoid arthritis (RA) is an autoimmune disease involving antigen-specific T and B cells. Here, we perform single-cell RNA and repertoire sequencing on paired synovial tissue and blood samples from 12 seropositive RA patients. We identify clonally expanded CD4 + T cells, including CCL5+ cells and T peripheral helper (Tph) cells, which show a prominent transcriptomic signature of recent activation and effector function. CD8 + T cells show higher oligoclonality than CD4 + T cells, with the largest synovial clones enriched in GZMK+ cells. CD8 + T cells with possibly virus-reactive TCRs are distributed across transcriptomic clusters. In the B cell compartment, NR4A1+ activated B cells, and plasma cells are enriched in the synovium and demonstrate substantial clonal expansion. We identify synovial plasma cells that share BCRs with synovial ABC, memory, and activated B cells. Receptor-ligand analysis predicted IFNG and TNFRSF members as mediators of synovial Tph-B cell interactions. Together, these results reveal clonal relationships between functionally distinct lymphocyte populations that infiltrate the synovium of patients with RA