The Tianlai Cylinder Pathfinder array: System functions and basic performance analysis

The Tianlai Cylinder Pathfinder is a radio interferometer array designed to test techniques for 21 cm intensity mapping in the post-reionization Universe, with the ultimate aim of mapping the large scale structure and measuring cosmological parameters such as the dark energy equation of state. Each of its three parallel cylinder reflectors is oriented in the north-south direction, and the array has a large field of view. As the Earth rotates, the northern sky is observed by drift scanning. The array is located in Hongliuxia, a radio-quiet site in Xinjiang, and saw its first light in September 2016. In this first data analysis paper for the Tianlai cylinder array, we discuss the sub-system qualification tests, and present basic system performance obtained from preliminary analysis of the commissioning observations during 2016-2018. We show typical interferometric visibility data, from which we derive the actual beam profile in the east-west direction and the frequency band-pass response. We describe also the calibration process to determine the complex gains for the array elements, either using bright astronomical point sources, or an artificial on site calibrator source, and discuss the instrument response stability, crucial for transit interferometry. Based on this analysis, we find a system temperature of about 90 K, and we also estimate the sensitivity of the array

Study on the sealing test method of hydraulic solenoid valve in nuclear power station

In order to improve the reliability of tripping solenoid valve and switching solenoid valve of steam turbine valve in nuclear power plant and reduce abnormal valve closing. According to the working principle of valves in nuclear power plant, this paper designs a kind of electromagnetic valve sealing test system, including test base, measurement and control system and hydraulic system. The detection system is an offline system. By simulating the real load condition of the steam turbine system, the tightness of the tripping solenoid valve and the switching solenoid valve is tested to improve the reliability of the solenoid valve. The actual application results show that the system operates stably and reliably, is simple to operate, has high detection efficiency and accuracy, and has good use effect

Study on current characteristic detection method of hydraulic solenoid valve in nuclear power plant

In this paper, a set of electromagnetic valve current characteristic test system is designed to improve the reliability of the trip solenoid valve in the field steam turbine system of nuclear power plant. The test system starts from the field requirements, working principle of solenoid valve, software control and other aspects to complete the pressure suppression function of the hydraulic test system and the functions of data acquisition, storage, display, playback and so on. The test system is composed of a hydraulic system and an electrical control system. The system verifies the reliability of the tested object by detecting the important parameters of the solenoid valve, calibrating the current characteristic points, calculating the characteristic parameters, and judging whether the test is qualified. The test results show that the system has been successfully applied in nuclear power field, meets the needs of the site, and works well

Ibrutinib Inhibits BTK Signaling in Tumor-Infiltrated B Cells and Amplifies Antitumor Immunity by PD-1 Checkpoint Blockade for Metastatic Prostate Cancer

Metastatic prostate cancer (PCa) remains incurable and causes considerably diminished overall survival. Despite significant progress in pharmacotherapy, the disease prognosis remains unchanged. Immune checkpoint inhibitors (ICIs) have demonstrated effectiveness in treating various advanced malignancies, but their efficacy in metastatic PCa is relatively limited. Previous studies have confirmed the immunosuppressive role of tumor-infiltrating B cells (TIL-Bs) in the PCa microenvironment, which accounts for their poor immunogenic potency. In this study, we demonstrated that an oral kinase agent, ibrutinib, strongly potentiated anti-PD-1 checkpoint blockade efficacy and successfully controlled tumor growth in a murine orthotopic PCa model constructed using a metastatic and hormone-independent cell line (RM-1). We identified close relationships between TIL-Bs, Bruton’s tyrosine kinase (BTK), and immunosuppressive molecules by bioinformatics and histological analysis. An in vitro study showed that a low dose of ibrutinib significantly inhibited B cell proliferation and activation as well as IL-10 production through the BTK pathway. Moreover, ibrutinib-treated B cells promoted CD8+ T cell proliferation and inhibitory receptor (IR) expression. However, the same dose of ibrutinib was insufficient to induce apoptosis in cancer cells. An in vivo study showed that ibrutinib monotherapy failed to achieve tumor regression in murine models but decreased B cell infiltration and inhibited activation and IL-10 production. More importantly, CD8+ T cell infiltration increased with high IR expression. Ibrutinib synergized with anti-PD-1 checkpoint blockade enormously improved antitumor immunity, thereby reducing tumor volume in the same scenario. These data set the scene for the clinical development of ibrutinib as an immunogenic trigger to potentiate anti-PD-1 checkpoint blockade for metastatic PCa immunotherapy