Learning the Joint Representation of Heterogeneous Temporal Events for Clinical Endpoint Prediction

The availability of a large amount of electronic health records (EHR) provides huge opportunities to improve health care service by mining these data. One important application is clinical endpoint prediction, which aims to predict whether a disease, a symptom or an abnormal lab test will happen in the future according to patients' history records. This paper develops deep learning techniques for clinical endpoint prediction, which are effective in many practical applications. However, the problem is very challenging since patients' history records contain multiple heterogeneous temporal events such as lab tests, diagnosis, and drug administrations. The visiting patterns of different types of events vary significantly, and there exist complex nonlinear relationships between different events. In this paper, we propose a novel model for learning the joint representation of heterogeneous temporal events. The model adds a new gate to control the visiting rates of different events which effectively models the irregular patterns of different events and their nonlinear correlations. Experiment results with real-world clinical data on the tasks of predicting death and abnormal lab tests prove the effectiveness of our proposed approach over competitive baselines.Comment: 8 pages, this paper has been accepted by AAAI 201

HieNet: Bidirectional Hierarchy Framework for Automated ICD Coding

International Classification of Diseases (ICD) is a set of classification codes for medical records. Automated ICD coding, which assigns unique International Classification of Diseases codes with each medical record, is widely used recently for its efficiency and error-prone avoidance. However, there are challenges that remain such as heterogeneity, label unbalance, and complex relationships between ICD codes. In this work, we proposed a novel Bidirectional Hierarchy Framework(HieNet) to address the challenges. Specifically, a personalized PageRank routine is developed to capture the co-relation of codes, a bidirectional hierarchy passage encoder to capture the codes' hierarchical representations, and a progressive predicting method is then proposed to narrow down the semantic searching space of prediction. We validate our method on two widely used datasets. Experimental results on two authoritative public datasets demonstrate that our proposed method boosts state-of-the-art performance by a large margin