Model Sensitivity in Holographic Superconductors and Their Deconstructed Cousins

Holographic models of superconductors successfully reproduce certain experimental features of high-temperature superconductors, such as a large gap-to-Tc ratio compared to that of conventional superconductors. By deconstructing the extra dimension of these holographic models, similar phenomenology is described by a class of models defined in the natural dimension of the superconducting system. We analyze the sensitivity of certain observables in holographic and deconstructed holographic superconductors to details of the extra-dimensional spacetime. Our results support the notion that certain quantitative successes of simple models of this type are accidental. However, we also find a certain universal relationship between superconducting observables

Holographic Bosonic Technicolor

We consider a technicolor model in which the expectation value of an additional, possibly composite, scalar field is responsible for the generation of fermion masses. We define the dynamics of the strongly coupled sector by constructing its holographic dual. Using the AdS/CFT correspondence, we study the S parameter and the phenomenology of the light technihadrons. We find that the S parameter is small over a significant region of the model's parameter space. The particle spectrum is distinctive and includes a nonstandard Higgs boson as well as heavier hadronic resonances. Technihadron masses and decay rates are calculated holographically, as a function of the model's parameters.Comment: 20 Pages, 4 eps figures, REVTex. Minor corrections and comments adde

Climate Process Team: improvement of ocean component of NOAA Climate Forecast System relevant to Madden-Julian Oscillation simulations

© The Author(s), 2021. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Shinoda, T., Pei, S., Wang, W., Fu, J. X., Lien, R.-C., Seo, H., & Soloviev, A. Climate Process Team: improvement of ocean component of NOAA Climate Forecast System relevant to Madden-Julian Oscillation simulations. Journal of Advances in Modeling Earth Systems, 13(12), (2021): e2021MS002658, https://doi.org/10.1029/2021MS002658.Given the increasing attention in forecasting weather and climate on the subseasonal time scale in recent years, National Oceanic and Atmospheric Administration (NOAA) announced to support Climate Process Teams (CPTs) which aim to improve the Madden-Julian Oscillation (MJO) prediction by NOAA’s global forecasting models. Our team supported by this CPT program focuses primarily on the improvement of upper ocean mixing parameterization and air-sea fluxes in the NOAA Climate Forecast System (CFS). Major improvement includes the increase of the vertical resolution in the upper ocean and the implementation of General Ocean Turbulence Model (GOTM) in CFS. In addition to existing mixing schemes in GOTM, a newly developed scheme based on observations in the tropical ocean, with further modifications, has been included. A better performance of ocean component is demonstrated through one-dimensional ocean model and ocean general circulation model simulations validated by the comparison with in-situ observations. These include a large sea surface temperature (SST) diurnal cycle during the MJO suppressed phase, intraseasonal SST variations associated with the MJO, ocean response to atmospheric cold pools, and deep cycle turbulence. Impact of the high-vertical resolution of ocean component on CFS simulation of MJO-associated ocean temperature variations is evident. Also, the magnitude of SST changes caused by high-resolution ocean component is sufficient to influence the skill of MJO prediction by CFS.This research was supported by NOAA Grant NA15OAR431074. Computing resources were provided partly by the HPC systems at the Texas A&M University (College Station and Corpus Christi) and the Climate Simulation Laboratory at NCAR's Computational and Information Systems Laboratory, sponsored by the National Science Foundation. TS and SP are supported by DOD Grant W911NF-20-1-0309. TS is also supported by NSF Grant OCE-1658218 and NOAA Grant NA17OAR4310256

Nucleotide Excision Repair- and Polymerase Eta-Mediated Error-Prone Removal of Mitomycin C Interstrand Cross-Links

Interstrand cross-links (ICLs) make up a unique class of DNA lesions in which both strands of the double helix are covalently joined, precluding strand opening during replication and transcription. The repair of DNA ICLs has become a focus of study since ICLs are recognized as the main cytotoxic lesion inflicted by an array of alkylating compounds used in cancer treatment. As is the case for double-strand breaks, a damage-free homologous copy is essential for the removal of ICLs in an error-free manner. However, recombination-independent mechanisms may exist to remove ICLs in an error-prone fashion. We have developed an in vivo reactivation assay that can be used to examine the removal of site-specific mitomycin C-mediated ICLs in mammalian cells. We found that the removal of the ICL from the reporter substrate could take place in the absence of undamaged homologous sequences in repair-proficient cells, suggesting a cross-link repair mechanism that is independent of homologous recombination. Systematic analysis of nucleotide excision repair mutants demonstrated the involvement of transcription-coupled nucleotide excision repair and a partial requirement for the lesion bypass DNA polymerase eta encoded by the human POLH gene. From these observations, we propose the existence of a recombination-independent and mutagenic repair pathway for the removal of ICLs in mammalian cells

Regulation of Nrf2 by X Box-Binding Protein 1 in Retinal Pigment Epithelium

Normal function of the retinal pigment epithelium (RPE) is essential for maintaining the structural integrity of retinal photoreceptors and the visual process. Sustained oxidative damage of the RPE due to aging and other risk factors contributes to the development of age-related macular degeneration (AMD). The transcription factor NF-E2-related factor 2 (Nrf2) is a central regulator of cellular antioxidant and detoxification responses. Enhancing Nrf2 function protects RPE cells from oxidation-related apoptosis and cell death. Previously, we demonstrated that Nrf2 activation can be induced by endoplasmic reticulum (ER) stress; however, the mechanisms are not fully understood. In the present study, we examined the role of X box-binding protein 1 (XBP1), an ER stress-inducible transcription factor, in regulation of Nrf2 in the RPE. We found that RPE-specific XBP1 conditional knockout (cKO) mice exhibit a significant reduction in Nrf2 mRNA and protein levels, along with decreased expression of major Nrf2 target genes, in the RPE/choroid complex. Using primary RPE cells isolated from XBP1 cKO mice and human ARPE-19 cell line, we confirmed that loss of XBP1 gene or pharmacological inhibition of XBP1 splicing drastically reduces Nrf2 levels in the RPE. Conversely, overexpression of spliced XBP1 results in a modest but significant increase in cytosolic and nuclear Nrf2 protein levels without affecting the transcription of Nrf2 gene. Moreover, induction of ER stress by tunicamycin and thapsigargin markedly increases Nrf2 expression, which is abolished in cells pretreated with XBP1 splicing inhibitors 4μ8C and quinotrierixin. Mechanistic studies indicate that quinotrierixin reduces Nrf2 expression likely through inhibition of protein translation. Finally, we demonstrate that overexpression of Nrf2 protected RPE cells against oxidative injury but appeared to be insufficient to rescue from XBP1 deficiency-induced cell death. Taken together, our results indicate that XBP1 modulates Nrf2 activity in RPE cells and that XBP1 deficiency contributes to oxidative injury of the RPE