Morphology investigation on direct current pulsed gas tungsten arc welded additive layer manufactured Ti6Al4V alloy

The effects of pulsed gas tungsten arc weldingparameters on the morphology of additive layer manufacturedTi6Al4V has been investigated in this study. Thepeak/ base current ratio and pulse frequency are found tohave no significant effect on the refinement of prior betagrain size. However, it is found that the wire feed ratehas a considerable effect on the prior beta grainrefinement at a given heat input. This is due to the extrawire input being able to supply many heterogeneousnucleation sites and also results in a negative temperaturegradient in the front of the liquidus which blocks thecolumnar growth and changes the columnar growth toequiaixal growth

Growth of Thin Oxidation-Resistive Crystalline Si Nanostructures on Graphene

We report the growth of Si nanostructures, either as thin films or nanoparticles, on graphene substrates. The Si nanostructures are shown to be single crystalline, air stable and oxidation resistive, as indicated by the observation of a single crystalline Si Raman mode at around 520 cm-1, a STM image of an ordered surface structure under ambient condition, and a Schottky junction with graphite. Ultra-thin silicon regions exhibit silicene-like behavior, including a Raman mode at around 550 cm-1, a triangular lattice structure in STM that has distinctly different lattice spacing from that of either graphene or thicker Si, and metallic conductivity of up to 500 times higher than that of graphite. This work suggests a bottom-up approach to forming a Si nanostructure array on a large scale patterned graphene substrate for fabricating nanoscale Si electronic devices

Pyrosequencing analysis of IRS1 methylation levels in schizophrenia with tardive dyskinesia

Tardive dyskinesia (TD) is a serious side effect of certain antipsychotic medications that are used to treat schizophrenia (SCZ) and other mental illnesses. The methylation status of the insulin receptor substrate 1 (IRS1) gene is reportedly associated with SCZ; however, no study, to the best of the authors\u27 knowledge, has focused on the quantitative DNA methylation levels of the IRS1 gene using pyrosequencing in SCZ with or without TD. The present study aimed to quantify DNA methylation levels of 4 CpG sites in the IRS1 gene using a Chinese sample including SCZ patients with TD and without TD (NTD) and healthy controls (HCs). The general linear model (GLM) was used to detect DNA methylation levels among the 3 proposed groups (TD vs. NTD vs. HC). Mean DNA methylation levels of 4 CpG sites demonstrated normal distribution. Pearson\u27s correlation analysis did not reveal any significant correlations between the DNA methylation levels of the 4 CpG sites and the severity of SCZ. GLM revealed significant differences between the 3 groups for CpG site 1 and the average of the 4 CpG sites (P=0.0001 and P=0.0126, respectively). Furthermore, the TD, NTD and TD + NTD groups demonstrated lower methylation levels in CpG site 1 (P=0.0003,

Preparation of CL-20 Explosive Nanoparticles and Their Thermal Decomposition Property

Herein, we develop a novel method for preparing nanohexanitrohexaazaisowurtzitane (nano-CL-20) via ultrasonic spray-assisted electrostatic adsorption (USEA) technology. Various experimental conditions which influence safety factors and the crystallization process were studied. Meanwhile, the prepared nano-CL-20 particles were characterized by field emission scanning electron microscopy (FE-SEM), X-ray diffraction (XRD), and Fourier transform infrared (FT-IR) spectroscopy. The results show that the obtained nano-CL-20 showed a wide size distribution in the range from 150 to 600 nm with an average of 270 nm. Moreover, their thermal properties were also investigated by differential scanning calorimetry (DSC) and thermogravimetry (TG). For nano-CL-20, the exothermal peak is 232.9°C increased by 12°C compared with conventionally manufactured (CM) CL-20, and they exhibit fast energy release efficiency as well as more energy release. The simple and continuous approach presented here is expected to be an attractive potential for fabricating other organic nanoparticles

Síntese dos aspectos centrais da perspectiva teórica de Sidney Blatt sobre a depressão (*)

Neste artigo apresentamos os aspectos centrais da perspectiva teórica de Sidney Blatt sobre a depressão. Expomos alguns aspectos gerais do seu modelo, as características dos dois tipos depressivos propostos por Blatt, algumas notas sobre o desenvolvimento das representações objectais e sobre os antecedentes da depressão e expomos ainda a componente de vulnerabilidade multi-causal do modelo de Blatt. Terminamos com algumas considerações finaisABSTRACT: In this article we present the most important aspects of Sidney Blatt’s theoretical perspective on depression. We present some general aspects of his model, the characteristics of the two depression types proposed by Blatt, some notes about the development of objectal representations and about the depression’s antecedents and also the multi-causal vulnerability component of Blatt’s model. We finish with some final considerationsinfo:eu-repo/semantics/publishedVersio

Waterlogging-responsive Genes Revealed by Transcriptome Sequencing in Leaves of Two Crabapple Species with Contrasting Waterlogging Tolerance

Crabapples (Malus sp.) are ornamental woody plants that belong to the Rosaceae family. Flooding has severely hampered the growth and development of crabapple, and little is known about the molecular responses of crabapple to waterlogging tolerance. Cuttings of waterlogging-tolerant Malus hupehensis and waterlogging-intolerant Malus halliana received flooding treatment of 30 days and regular planting, respectively. Using transcriptome sequencing, we isolated 5703 and 2735 waterlogging-responsive genes from waterlogging-treated M. hupehensis and M. halliana leaves. Among these differentially expressed genes (DEGs), only 746 were shared by both. Several variables may explain the greater waterlogging tolerance of M. hupehensis: there were more waterlogging response genes related to carbohydrate and energy metabolism; signal transduction; antioxidation; lipid metabolism; protein and amino acid metabolism; and polysaccharide, cell wall, and cytoskeleton metabolism pathway in the waterlogged leaves of M. hupehensis than in M. halliana. In particular, the number of DEGs related to anaerobic metabolism, fatty acid metabolism, protein phosphorylation and dephosphorylation, γ-aminobutyric acid metabolism and cellulase, pectinase metabolism pathway in the flooded leaves of M. hupehensis was more than that in M. halliana. The alterations in gene expression patterns of the two crabapple species induced by waterlogging varied substantially. These outcomes pave the way for further studies into the functions of genes that may be involved in waterlogging tolerance in crabapples

Short-term efficacy of stenting as a rescue therapy for acute atherosclerotic occlusion in anterior cerebral circulation

PurposeThe study aimed to explore the efficacy and safety of the Neuroform EZ stent in treating acute anterior circulation large artery occlusion.MethodsThe clinical data of 42 consecutive patients with acute anterior circulation large atherosclerotic occlusion who were treated with the Neuroform EZ stent from January 2018 to August 2019 in our stroke care center, including baseline characteristics, images, therapeutic condition, and follow-up data were retrospectively analyzed.ResultsThere were 42 mechanical thrombectomy (MT) failure cases of intracranial atherosclerotic stenosis with rescue Neuroform EZ stent implantation, of which 78.6% (33/42) had a good prognosis and 88.1% (37/42) showed no re-stenosis at follow-up. The average time from puncture to recanalization is 79.50 ± 14.19 min. The successful rate of intraoperative stent release is 97.6%, while there is one case of stent displacement, three cases of thrombus escape, and six cases of hemorrhage.ConclusionRescue therapy of the Neuroform EZ stent for acute anterior circulation large atherosclerotic occlusion can archive good short-term imaging and clinical results, while long-term follow-up is still needed to verify

Individual differences in schizophrenia

Background: Whether there are distinct subtypes of schizophrenia is an important issue to advance understanding and treatment of schizophrenia. Aims: To understand and treat individuals with schizophrenia, the aim was to advance understanding of differences between individuals, whether there are discrete subtypes, and how fist-episode patients (FEP) may differ from multiple episode patients (MEP). Method: These issues were analysed in 687 FEP and 1880 MEP with schizophrenia using the Positive and Negative Syndrome Scale for (PANSS) schizophrenia before and after antipsychotic medication for 6 weeks. Results: The seven Negative Symptoms were correlated with each other and with P2 (conceptual disorganisation), G13 (disturbance of volition), and G7 (motor retardation). The main difference between individuals was in the cluster of seven negative symptoms, which had a continuous unimodal distribution. Medication decreased the PANSS scores for all the symptoms, which were similar in the FEP and MEP groups. Conclusions: The negative symptoms are a major source of individual differences, and there are potential implications for treatment

Effects of WAAM Process Parameters on Metallurgical and Mechanical Properties of Ti-6Al-4V Deposits

Additive manufacturing is a revolution for many sectors of the industry. These new manufacturing processes allow a substantial saving of raw material while optimizing the geometry, and at the same time reducing development costs, by reducing the time between the concept and deployment phases of a product. A 3D printing device using a Cold Metal Transfer (CMT) arc welding station to melt a metallic filler wire is developed to build titanium parts by optimizing the process parameters to control metallurgical and mechanical properties of parts. In this study, two parameters (wire feed speed and movement speed of the robot) have been studied. Their impact on the metallurgical, dimensional process stability and mechanical properties of materials have been analyzed. Microstructure and mechanical properties vary depending on the energy expended during manufacture. This energy remains constant or decreases respectively when the wire feed speed or the robot head travel speed increases. Indeed, the electric generator adapts its power according to the speed of the wire. Regardless of the energy parameters, the movement speed of the robot seems to influence the wetting angles, the depth of melted zones, remelted and heat affected zones and the metallurgy with a refinement of the substructure of the deposits

Improvement of social functioning in patients with first-episode schizophrenia using blonanserin treatment: a prospective, multi-centre, single-arm clinical trial

ObjectivesThis clinical trial primarily aimed to investigate the effects of blonanserin on social functioning in patients with first-episode schizophrenia.MethodsIn this prospective, multi-centre, single-arm clinical trial study, blonanserin (flexible oral dose ranging from 8mg to 24mg per day) was given 26 weeks. Outcome measures included the Personal and Social Performance (PSP) scale for evaluating social functioning, the Measurement and Treatment Research to Improve Cognition in Schizophrenia Consensus Cognitive Battery (MCCB) for measuring neurocognitive performance, and the Positive and Negative Syndrome Scale (PANSS) for assessing symptom severity. The primary endpoint was social function improvement evaluated by PSP scale at the end of blonanserin treatment. And the secondary endpoint was to validate the efficacy and neurocognitive effects of blonanserin. Adverse drug reactions (ADRs) were also recorded and analysed.ResultsA total of 96 patients with first-episode schizophrenia were recruited and proceeded to analysis. Fifty-one participants (53.1%) completed the PSP scale measurements at baseline and week 26. Following 26 weeks of blonanserin treatment, all outcome measurements demonstrated significant improvement during the follow-up period. Notably, PSP scores exhibited a continuous increase up to 68.1% ± 103.7% at the end of the treatment (46.6 ± 14.6 at baseline, 69.4 ± 17.4 at week 26, p<0.001), indicating positive effects on social functioning that were already noticeable by week 8.ConclusionBlonanserin treatment exhibited favourable effects on social functioning in individuals with first-episode schizophrenia. The results suggest that blonanserin was effective treatment options for patients with schizophrenia encountering functional impairments