Deepening China-Taiwan Relations through the Economic Cooperation Framework Agreement

On June 13, 2010, representatives from China and Taiwan held a third round of talks in Beijing on an Economic Cooperation Framework Agreement (ECFA) that would liberalize important aspects of cross-Strait economic relations. It is clear from available details that ECFA will be an ambitious accord that fundamentally changes the game between Taiwan and China and hence affects the regional economy and even the transpacific tempo for the United States. Rosen and Wang's economic projections of the effects of a China-Taiwan ECFA point to significant benefits of cross-Strait economic reform, especially for Taiwan, which would increase its 2020 GDP by about 4.5 percent, or $21 billion, from the current trend line. The authors, however, also conclude that the regional economy around China and Taiwan is not standing still but is extraordinarily dynamic. Other agreements in the region will be negotiated (e.g., ASEAN+3), which will impose costs on Taiwan, if it does not do an ECFA, to the tune of almost -0.8 percent of GDP. So the net effect of ECFA for Taiwan would be some 5.3 percent improvement in GDP by 2020. For China, the net results of ECFA are positive, though far less so than for Taiwan in value terms and of course as a share of GDP. For the United States, the authors project a very modest positive result from ECFA (though statistically marginal) but a more negative impact as the scenarios incorporating further Asian integration (ASEAN + 3) unfold. If the US objective is to maximize Taiwan's economic prospects and hence its freedom of independent action, then ECFA is highly desirable, and Taiwan's involvement in further Asian deepening is to be supported. However, US economic interests per se erode as Asia draws tighter together without US inclusion. That is an econometric reality. More significant still is the geoeconomic, qualitative implication of even long-standing nemeses China and Taiwan drawing together in a free trade pact while the United States watches, unable to ratify already negotiated Asian trade agreements like the US-Korea free trade agreement. While modest in global economic effects, the geoeconomic implications of a China-Taiwan economic pact are significant enough to demand strategic attention from the United States and underscore the importance of securing US economic engagement of the first order in Asia.

The 125 GeV Higgs and Electroweak Phase Transition Model Classes

Recently, the ATLAS and CMS detectors have discovered a bosonic particle which, to a reasonable degree of statistical uncertainty, fits the profile of the Standard Model Higgs. One obvious implication is that models which predict a significant departure from Standard Model phenomenology, such as large exotic (e.g., invisible) Higgs decay or mixing with a hidden sector scalar, are already ruled out. This observation threatens the viability of electroweak baryogenesis, which favors, for example, a lighter Higgs and a Higgs coupled to or mixed with light scalars. To assess the broad impact of these constraints, we propose a scheme for classifying models of the electroweak phase transition and impose constraints on a class-by-class basis. We find that models, such as the MSSM, which rely on thermal loop effects are severely constrained by the measurement of a 125 GeV Higgs. Models which rely on tree-level effects from a light singlet are also restricted by invisible decay and mixing constraints. Moreover, we find that the parametric region favored by electroweak baryogenesis often coincides with an enhanced symmetry point with a distinctive phenomenological character. In particular, enhancements arising through an approximate continuous symmetry are phenomenologically disfavored, in contrast with enhancements from discrete symmetries. We also comment on the excess of diphoton events observed by ATLAS and CMS. We note that although Higgs portal models can accommodate both enhanced diphoton decay and a strongly first order electroweak phase transition, the former favors a negative Higgs portal coupling whereas the latter favors a positive one, and therefore these two constraints are at tension with one another.Comment: 35 pages, 7 figure

Detection of X-ray-Emitting Hypernova Remnants in M101

Based on an ultra deep (230 ks) ROSAT HRI imaging of M101, we have detected 5 X-ray sources that coincide spatially with optical emission line features previously classified as supernova remnants in this nearby galaxy. Two of these coincidences (SNR MF83 and NGC5471B) most likely represent the true physical association of X-ray emission with shock-heated interstellar gas. MF83, with a radius of ~ 134 pc, is one of the largest remnants known. NGC5471B, with a radius of 30 pc and a velocity of at least 350 km/s (FWZI), is extremely bright in both radio and optical. The X-ray luminosities of these two shell-like remnants are $\sim 1$ and $3 \times 10^{38} ergs/s$ (0.5-2 keV), about an order of magnitude brighter than the brightest supernova remnants known in our Galaxy and in the Magellanic Clouds. The inferred blastwave energy is $\sim 3 \times 10^{52} ergs$ for NGC5471B and $\sim 3 \times 10^{53}$ ergs for MF83. Therefore, the remnants likely originate in hypernovae, which are a factor of $\gtrsim 10$ more energetic than canonical supernovae and are postulated as being responsible for Gamma-ray bursts observed at cosmological distances. The study of such hypernova remnants in nearby galaxies has the potential to provide important constraints on the progenitor type, rate, energetics, and beaming effect of Gamma-ray bursts.Comment: 10 pages, 2 gif figures, Accepted for publication in Astrophysical Journal Letter

Strongly First Order Phase Transitions Near an Enhanced Discrete Symmetry Point

We propose a group theoretic condition which may be applied to extensions of the Standard Model in order to locate regions of parameter space in which the electroweak phase transition is strongly first order, such that electroweak baryogenesis may be a viable mechanism for generating the baryon asymmetry of the universe. Specifically, we demonstrate that the viable corners of parameter space may be identified by their proximity to an enhanced discrete symmetry point. At this point, the global symmetry group of the theory is extended by a discrete group under which the scalar sector is non-trivially charged, and the discrete symmetry is spontaneously broken such that the discrete symmetry relates degenerate electroweak preserving and breaking vacua. This idea is used to investigate several specific models of the electroweak symmetry breaking sector. The phase transitions identified through this method suggest implications for other relics such as dark matter and gravitational waves.Comment: 17 pages, 4 figure

A Critical Examination of Hypernova Remnant Candidates in M101. II. NGC 5471B

NGC 5471B has been suggested to contain a hypernova remnant because of its extraordinarily bright X-ray emission. To assess its true nature, we have obtained high-resolution images in continuum bands and nebular lines with the Hubble Space Telescope, and high-dispersion long-slit spectra with the Kitt Peak National Observatory 4-m echelle spectrograph. The images reveal three supernova remnant (SNR) candidates in the giant HII region NGC 5471, with the brightest one being the 77x60 pc shell in NGC 5471B. The Ha velocity profile of NGC 5471B can be decomposed into a narrow component (FWHM = 41 km/s) from the background HII region and a broad component (FWHM = 148 km/s) from the SNR shell. Using the brightness ratio of the broad to narrow components and the Ha flux measured from the WFPC2 Ha image, we derive an Ha luminosity of (1.4+-0.1)x10^39 ergs/s for the SNR shell. The [SII]6716,6731 doublet ratio of the broad velocity component is used to derive an electron density of ~700 cm^-3 in the SNR shell. The mass of the SNR shell is thus 4600+-500 Mo. With a \~330 km/s expansion velocity implied by the extreme velocity extent of the broad component, the kinetic energy of the SNR shell is determined to be 5x10^51 ergs. This requires an explosion energy greater than 10^52 ergs, which can be provided by one hypernova or multiple supernovae. Comparing to SNRs in nearby active star formation regions, the SNR shell in NGC 5471B appears truly unique and energetic. We conclude that the optical observations support the existence of a hypernova remnant in NGC 5471B.Comment: 27 pages, 9 figures, to appear in May 2002 issue of The Astronomical Journa

Time-Restricted Feeding Improves Circadian Dysfunction as well as Motor Symptoms in the Q175 Mouse Model of Huntington's Disease.

Huntington's disease (HD) patients suffer from a progressive neurodegeneration that results in cognitive, psychiatric, cardiovascular, and motor dysfunction. Disturbances in sleep/wake cycles are common among HD patients with reports of delayed sleep onset, frequent bedtime awakenings, and fatigue during the day. The heterozygous Q175 mouse model of HD has been shown to phenocopy many HD core symptoms including circadian dysfunctions. Because circadian dysfunction manifests early in the disease in both patients and mouse models, we sought to determine if early intervention that improve circadian rhythmicity can benefit HD and delay disease progression. We determined the effects of time-restricted feeding (TRF) on the Q175 mouse model. At six months of age, the animals were divided into two groups: ad libitum (ad lib) and TRF. The TRF-treated Q175 mice were exposed to a 6-h feeding/18-h fasting regimen that was designed to be aligned with the middle of the time when mice are normally active. After three months of treatment (when mice reached the early disease stage), the TRF-treated Q175 mice showed improvements in their locomotor activity rhythm and sleep awakening time. Furthermore, we found improved heart rate variability (HRV), suggesting that their autonomic nervous system dysfunction was improved. Importantly, treated Q175 mice exhibited improved motor performance compared to untreated Q175 controls, and the motor improvements were correlated with improved circadian output. Finally, we found that the expression of several HD-relevant markers was restored to WT levels in the striatum of the treated mice using NanoString gene expression assays

Associations of Adiponectin with Adiposity, Insulin Sensitivity, and Diet in Young, Healthy, Mexican Americans and Non-Latino White Adults.

Low circulating adiponectin levels may contribute to higher diabetes risk among Mexican Americans (MA) compared to non-Latino whites (NLW). Our objective was to determine if among young healthy adult MAs have lower adiponectin than NLWs, independent of differences in adiposity. In addition, we explored associations between adiponectin and diet. This was an observational, cross-sectional study of healthy MA and NLW adults living in Colorado (U.S.A.). We measured plasma total adiponectin, adiposity (BMI, and visceral adipose tissue), insulin sensitivity (IVGTT), and self-reported dietary intake in 43 MA and NLW adults. Mean adiponectin levels were 40% lower among MA than NLW (5.8 ± 3.3 vs. 10.7 ± 4.2 µg/mL, p = 0.0003), and this difference persisted after controlling for age, sex, BMI, and visceral adiposity. Lower adiponectin in MA was associated with lower insulin sensitivity (R² = 0.42, p < 0.01). Lower adiponectin was also associated with higher dietary glycemic index, lower intake of vegetables, higher intake of trans fat, and higher intake of grains. Our findings confirm that ethnic differences in adiponectin reflect differences in insulin sensitivity, but suggest that these are not due to differences in adiposity. Observed associations between adiponectin and diet support the need for future studies exploring the regulation of adiponectin by diet and other environmental factors

The Feasibility of Imaging Myocardial Ischemic/Reperfusion Injury Using \u3csup\u3e99m\u3c/sup\u3eTc-labeled Duramycin in a Porcine Model

When pathologically externalized, phosphatidylethanolamine (PE) is a potential surrogate marker for detecting tissue injuries. 99mTc-labeled duramycin is a peptide-based imaging agent that binds PE with high affinity and specificity. The goal of the current study was to investigate the clearance kinetics of 99mTc-labeled duramycin in a large animal model (normal pigs) and to assess its uptake in the heart using a pig model of myocardial ischemia–reperfusion injury. Methods The clearance and distribution of intravenously injected 99mTc-duramycin were characterized in sham-operated animals (n = 5). In a closed chest model of myocardial ischemia, coronary occlusion was induced by balloon angioplasty (n = 9). 99mTc-duramycin (10–15 mCi) was injected intravenously at 1 hour after reperfusion. SPECT/CT was acquired at 1 and 3 hours after injection. Cardiac tissues were analyzed for changes associated with acute cellular injuries. Autoradiography and gamma counting were used to determine radioactivity uptake. For the remaining animals, 99mTc-tetrafosamin scan was performed on the second day to identify the infarct site. Results Intravenously injected 99mTc-duramycin cleared from circulation predominantly via the renal/urinary tract with an α-phase half-life of 3.6 ± 0.3 minutes and β-phase half-life of 179.9 ± 64.7 minutes. In control animals, the ratios between normal heart and lung were 1.76 ± 0.21, 1.66 ± 0.22, 1.50 ± 0.20 and 1.75 ± 0.31 at 0.5, 1, 2 and 3 hours post-injection, respectively. The ratios between normal heart and liver were 0.88 ± 0.13, 0.80 ± 0.13, 0.82 ± 0.19 and 0.88 ± 0.14. In vivo visualization of focal radioactivity uptake in the ischemic heart was attainable as early as 30 min post-injection. The in vivo ischemic-to-normal uptake ratios were 3.57 ± 0.74 and 3.69 ± 0.91 at 1 and 3 hours post-injection, respectively. Ischemic-to-lung ratios were 4.89 ± 0.85 and 4.93 ± 0.57; and ischemic-to-liver ratios were 2.05 ± 0.30 to 3.23 ± 0.78. The size of 99mTc-duramycin positive myocardium was qualitatively larger than the infarct size delineated by the perfusion defect in 99mTc-tetrafosmin uptake. This was consistent with findings from tissue analysis and autoradiography. Conclusion 99mTc-duramycin was demonstrated, in a large animal model, to have suitable clearance and biodistribution profiles for imaging. The agent has an avid target uptake and a fast background clearance. It is appropriate for imaging myocardial injury induced by ischemia/reperfusion

Maine Monthly Overdose Report for August 2023

This report documents suspected and confirmed fatal and nonfatal drug overdoses in Maine during August 2023 as well as for the period January 2022–August 2023 (Table 1). During August 2023, the proportion of fatal overdoses averaged 5.8% of total overdoses. Monthly proportions of 2023 fatalities have fluctuated from a low of 4.1% in March to a high of 8.1% in April. During the period January–August 2023, fatal overdoses constituted 6.1% of all overdoses, lower than the 6.9% for the year in 2022. The total of confirmed and suspected fatal overdoses January