A Framing Analysis and Regional Comparison of Newspaper Media Reports of COVID-19 in Shanghai: Based on the LDA Topic Model

In this study, we analyzed reports published by local and non-local newspapers on the 2022 COVID-19 outbreak in Shanghai using the Latent Dirichlet Allocation (LDA) topic modeling technique. Framing Theory suggests that both coverage types would typically produce similar media frames, notwithstanding the presence of slight differences in bias. We identified the media frames used by local and non-local newspapers on the Shanghai outbreak and our analysis subsequently informed our discussion on the similarities and differences that were uncovered. The paper offers suggestions for media reporting on how to better cover the outbreak

Unraveling the Relationship between Content Quality, Design, and User Engagement in Douyin's Adolescent Mode

In recent years, short video social platforms have garnered widespread attention, with Douyin (the Chinese version of TikTok) being a typical representative. The daily active users of the teen segment in Douyin are estimated to exceed 42 million. However, there still exists a certain blind spot in the research of Douyin's teen-specific content. This study conducts a content analysis of 360 short videos in Douyin's adolescent mode, and employs a Structural Equation Model (SEM) to analyze the relationships between the content quality, design features, learning objectives, age appropriateness, and user engagement. The results reveal that age appropriateness and learning objectives have a significant positive impact on content quality, and content quality and design features significantly positively impact user engagement. Further discussions point out that Douyin's adolescent mode faces challenges in dealing with issues like gender bias and algorithm bias, which may have adverse effects on the holistic development of teen users. The research findings provide empirical evidence for short video creators and platform optimization, and put forward targeted suggestions for the design of short video content in adolescent mode

Corrosion Analysis and Corresponding Countermeasures of Steel Structures in Offshore Wind Farms

[Introduction] Strategies for preventing corrosion in steel structures at offshore wind farms, derived from a comprehensive study on the environmental conditions, symptoms, and mechanisms of corrosion in such structures, as well as an analysis on various causes were proposed, aiming to ensure safe operation throughout their lifecycle. [Method] The study focused on the grid-connected offshore wind farms and investigated corrosion observed in specific marine environmental conditions for different foundation types, structural components, materials, and parts. [Result] The results show that corrosion appears in various forms and progresses at varying rates among different foundation types, structural components, and parts in specific marine environmental conditions. Electrochemical corrosion is identified as the main form of corrosion, while internal and external stresses act as potential accelerators of corrosion in steel structures. Manufacturing quality control and the implementation of protective measures directly affect the rate of corrosion development.[Conclusion] In summary, it is crucial to identify various potential risks related to manufacturing characteristics, material properties, and environmental conditions of steel structures at offshore wind farms and take appropriate refined protection measures to eliminate underlying causes. In addition, protection levels should be increased for certain critical parts

Experimental Research on Capacity Expansion of Large-Scale Offshore Wind Farm Under Multiple Wake Models

[Introduction] This article aims to study the optimal planned capacity setting of large-scale offshore wind farm. [Method] A series of numerical experiments were conducted on a single planned site with a capacity of 1 GW using three models with different unit capacities and three offshore wind farm wake models, combined with an offshore wind resource atlas, to gradually expand it to 2 GW. Power generation, wake effects and marginal utility of the whole site were analyzed. [Result] The results show that employing the wind turbine with larger single-unit capacity, the higher gaining of the power generation and slower growth of wake loss appear during the capacity expansion. Meanwhile, the larger effective expansion range which taking into account the safety of the wind turbine and the marginal utility exists. However, evaluation of effective expansion range may be affected by wake model selection. [Conclusion] This article shows that the optimal planned capacity of a single offshore wind farm can be slightly higher than the existing benchmark when multiple constraints, such as utilization of sea area, wind turbine safety and economical efficiency are met. Individual site needs to be subdivided scientifically and the optimal planned capacity should be reasonably set in the future planning of offshore wind farm bases with capacities in the tens of millions of kilowatts

PPM1D modulates hematopoietic cell fitness and response to DNA damage and is a therapeutic target in myeloid malignancy

PPM1D encodes a phosphatase that is recurrently activated across cancer, most notably in therapy-related myeloid neoplasms. However, the function of PPM1D in hematopoiesis and its contribution to tumor cell growth remain incompletely understood. Using conditional mouse models, we uncover a central role for Ppm1d in hematopoiesis and validate its potential as a therapeutic target. We find that Ppm1d regulates the competitive fitness and self-renewal of hematopoietic stem cells (HSCs) with and without exogenous genotoxic stresses. We also show that while Ppm1d activation confers cellular resistance to cytotoxic therapy, it does so to a lesser degree than p53 loss, informing the clonal competition phenotypes often observed in human studies. Notably, loss of Ppm1d sensitizes leukemias to cytotoxic therapies in vitro and in vivo, even in the absence of a Ppm1d mutation. Vulnerability to PPM1D inhibition is observed across many cancer types and dependent on p53 activity. Importantly, organism-wide loss of Ppm1d in adult mice is well tolerated, supporting the tolerability of pharmacologically targeting PPM1D. Our data link PPM1D gain-of-function mutations to the clonal expansion of HSCs, inform human genetic observations, and support the therapeutic targeting of PPM1D in cancer

Sputtering and amorphization of crystalline semiconductors by Nanodroplet Bombardment

In this review we expose how Nanodroplet Bombardment of surfaces by charged particles produced through electrospray atomization offers unparalleled opportunities for surface engineering of chemically inert crystalline materials. The sputtering yields and rates are comparable or higher than reactive etching techniques and significantly higher than other physical sputtering systems. Moreover, bombardment can amorphatize a thin layer of the target. The imposed physical characteristics of the electrospray, droplet diameter, molecular mass of the spray, and kinetic energy will determine the sputtering and amorphization efficiency, and the topography of the processed target. Molecular dynamics studies have clarified the mechanisms of both processes; amorphous layers appear due to ultra‐fast quenching of melted target pools around the impact area while sputtering is driven by a combination of collision cascades, thermal evaporation, and, for large and fast projectiles, of hydrodynamic forces

Photoacoustic/Ultrasound Endoscopic Imaging Reconstruction Algorithm Based on the Approximate Gaussian Acoustic Field

This paper aims to propose a new photoacoustic/ultrasound endoscopic imaging reconstruction algorithm based on the approximate Gaussian acoustic field which significantly improves the resolution and signal-to-noise ratio (SNR) of the out-of-focus region. We demonstrated the method by numerical calculations and investigated the applicability of the algorithm in a chicken breast phantom. The validation was finally performed by the rabbit rectal endoscopy experiment. Simulation results show that the lateral resolution of the target point in the out-of-focus region can be well optimized with this new algorithm. Phantom experimental results show that the lateral resolution of the indocyanine green (ICG) tube in the photoacoustic image is reduced from 3.975 mm to 1.857 mm by using our new algorithm, which is a 52.3% improvement. Ultrasound images also show a significant improvement in lateral resolution. The results of the rabbit rectal endoscopy experiment prove that the algorithm we proposed is capable of providing higher-quality photoacoustic/ultrasound images. In conclusion, the algorithm enables fast acoustic resolution photoacoustic/ ultrasonic dynamic focusing and effectively improves the imaging quality of the system, which has significant guidance for the design of acoustic resolution photoacoustic/ultrasound endoscopy systems

Synaptotagmin 1 and Ca2+ drive trans SNARE zippering

Synaptotagmin 1 (Syt1) is a major Ca(2+)-sensor that evokes neurotransmitter release. Here we used site-specific fluorescence resonance energy transfer (FRET) assay to investigate the effects of Syt1 on SNAREpin assembly. C2AB, a soluble version of Syt1, had virtually no stimulatory effect on the rate of the FRET at N-terminus of SNARE complex both with and without Ca(2+), indicating C2AB does not interfere with the initial nucleation of SNARE assembly. However, C2AB-Ca(2+) accelerated the FRET rate significantly at membrane proximal region, indicating C2AB-Ca(2+) promotes the transition from a partially assembled SNARE complex to the fusion-competent SNAREpin. Similar enhancement was also observed at the end of the transmembrane domain of SNARE proteins. The stimulatory effect disappeared if there was no membrane or only neutral membrane present