Searching for Dark Matter Signals in the Left-Right Symmetric Gauge Model with CP Symmetry

We investigate singlet scalar dark matter (DM) candidate in a left-right symmetric gauge model with two Higgs bidoublets (2HBDM) in which the stabilization of the DM particle is induced by the discrete symmetries P and CP. According to the observed DM abundance, we predict the DM direct and indirect detection cross sections for the DM mass range from 10 GeV to 500 GeV. We show that the DM indirect detection cross section is not sensitive to the light Higgs mixing and Yukawa couplings except the resonance regions. The predicted spin-independent DM-nucleon elastic scattering cross section is found to be significantly dependent on the above two factors. Our results show that the future DM direct search experiments can cover the most parts of the allowed parameter space. The PAMELA antiproton data can only exclude two very narrow regions in the 2HBDM. It is very difficult to detect the DM direct or indirect signals in the resonance regions due to the Breit-Wigner resonance effect.Comment: 24 pages, 8 figures. minor changes and a reference added, published in Phys. Rev.

SARS-CoV Regulates Immune Function-Related Gene Expressions in Human Monocytic Cells

Background: Severe Acute Respiratory Syndrome (SARS) is characterized by acute respiratory distress (ARDS) and pulmonary fibrosis, and the monocyte/macrophage is the key player in the pathogenesis of SARS.
 
Methods: In this study, we compared the transcriptional profiles of SARS coronavirus (SARS-CoV) infected monocytic cells against that infected by coronavirus 229E (CoV-229E). Total RNA was extracted from infected DC-SIGN transfected monocytes (THP-1-DC-SIGN) at 6 and 24 h after infection and the gene expression was profiled by oligonucleotide-based microarray. 

Results: Analysis of immune-related gene expression profiles showed that 24 h after SARS-CoV infection, (i) IFN-alpha/beta-inducible and cathepsin/proteosome genes were down-regulated; (ii) the hypoxia/hyperoxia-related genes were up-regulated; and (iii) the TLR/TLR-signaling, cytokine/cytokine receptor-related, chemokine/chemokine receptor-related, the lysosome-related, MHC/chaperon-related, and fibrosis-related genes were differentially regulated. 

Conclusion: These results elucidate that monocyte/macrophage dysfunction and dysregulation of fibrosis-related genes are two important pathogenic events of SARS. 
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Epoxy Interlocking: A Novel Approach to Enhance FRP-to-concrete Bond Behavior

This paper presents a novel approach which can enhance the interfacial bond behavior between fiber reinforced polymer (FRP) composite material and concrete. Epoxy ribs are formed by grooving on the concrete surface before epoxy is applied. The dowel action from the epoxy ribs leads to an “epoxy interlocking” effect. The mechanism of the proposed epoxy interlocking approach was analyzed in this paper from both adhesion and interlocking aspects. Furthermore, the partial interaction of the epoxy interlocking was quantified and calibrated by experimental results. The epoxy interlocking in the tested specimens led to an 88.8% increase in bond strength on average. An analytical approach was proposed to quantify the average partial interaction for the individual epoxy ribs. The load-slip relationship for individual epoxy ribs was found to be related to concrete compression behavior. A parametric study was conducted analytically on the effects of groove depth and spacing, concrete strength and epoxy rib location. The reasonable results in the parametric study further verify the efficiency of the epoxy interlocking to enhance the bond performance between FRP and concrete