Magnetic Impurities in Two-Dimensional Superfluid Fermi Gas with Spin-Orbit Coupling

We consider magnetic impurities in a two dimensional superfluid Fermi gas in the presence of spin-orbit coupling. By using the methods of t-matrix and Green's function, we find spin-orbit coupling has some dramatic impacts on the effects of magnetic impurities. For the single impurity problem, the number of bound states localized around the magnetic impurity is doubled. For the finite concentration $n$ of impurities, the energy gap is reduced and the density of states in the gapless region is greatly modified.Comment: 6 pages, 6 figure

Effect of bone morphogenetic protein-2 on diabetic retinopathy and its mechanism of action

Purpose: To investigate the effect of bone morphogenetic protein-2 (BMP-2) on human retinal vascular endothelial cells (RECs) and human retinal pigment epithelial cells (RPE) cultured in high glucose (HG) in vitro, and the underlying mechanism. Methods: Cell counting kit-8 (CCK-8) was used to determine cell proliferation while Western blot was used to assay the expressions of extracellular matrix and angiogenesis-related factors, Expressions of cytokines and chemokines were assessed by quantitative real time polymerase chain reaction (qRTPCR) and enzyme-linked immunosorbent assay (ELISA). Changes in Smad, ERK, JNK and p38MAPK signal pathway were measured by transfection and interference. Results: The level of expression of BMP-2 in HG group was higher than that in normal glucose (NG) culture group. The expressions of angiogenesis-related factors i.e. vascular endothelial growth factor (VEGF) and intercellular cell adhesion molecule-1 (ICAM1), pro-inflammatory factors i.e. IL-6 and chemokine monocyte chemokine protein-1 (MCP1), increased significantly in HG group compared to NG and HG + BMP-2 groups. Phosphorylation of Smad1/5/8 and activation of ERK, JNK and p38MAPK signaling pathways were enhanced by BMP-2. Conclusion: These results suggest that BMP-2 promotes angiogenesis and enhances the expressions of inflammatory cytokines via Smad signaling pathway

Targeted Poverty Alleviation and Households’ Livelihood Strategy in a Relation-Based Society: Evidence from Northeast China

Abstract: Although China is experiencing a transition from a relation-based society to a rule-based society, relationships among acquaintances still play an important role in resource allocation, such as the allocation of policy resources. This is particularly true in rural China, where targeted poverty alleviation is prevalent and a relation-based social structure still dominates. However, it is still unknown how relationships affect the livelihood strategy of households in rural China and how poverty alleviation policies plays a role between them. Therefore, this paper embeds poverty alleviation into the relation-based society and explores how households respond to the policy in this specific context. Using grounded theory research method and the sustainable livelihoods approach (SLA) framework, this paper contains in-depth interviews and field observations from three povertystricken villages in Northeast China. The results show that relationships have a significant impact on the households’ livelihood strategy. In other words, the households’ livelihood strategy is embedded in the relation-based society. The types of relationships induce households to choose maintained or developmental type livelihood strategies, while relationships influence how the poverty alleviation policies affect the livelihood strategy. This study is not only an extension of the SLA in the research context, but also provides a significant perspective for enriching the long-term mechanism of targeted poverty alleviation by building a theoretical model of the relationships between a relation-based society, targeted poverty alleviation and the livelihood strategies of households.publishedVersio

Near-Term Quantum Computing Techniques: Variational Quantum Algorithms, Error Mitigation, Circuit Compilation, Benchmarking and Classical Simulation

Quantum computing is a game-changing technology for global academia, research centers and industries including computational science, mathematics, finance, pharmaceutical, materials science, chemistry and cryptography. Although it has seen a major boost in the last decade, we are still a long way from reaching the maturity of a full-fledged quantum computer. That said, we will be in the Noisy-Intermediate Scale Quantum (NISQ) era for a long time, working on dozens or even thousands of qubits quantum computing systems. An outstanding challenge, then, is to come up with an application that can reliably carry out a nontrivial task of interest on the near-term quantum devices with non-negligible quantum noise. To address this challenge, several near-term quantum computing techniques, including variational quantum algorithms, error mitigation, quantum circuit compilation and benchmarking protocols, have been proposed to characterize and mitigate errors, and to implement algorithms with a certain resistance to noise, so as to enhance the capabilities of near-term quantum devices and explore the boundaries of their ability to realize useful applications. Besides, the development of near-term quantum devices is inseparable from the efficient classical simulation, which plays a vital role in quantum algorithm design and verification, error-tolerant verification and other applications. This review will provide a thorough introduction of these near-term quantum computing techniques, report on their progress, and finally discuss the future prospect of these techniques, which we hope will motivate researchers to undertake additional studies in this field.Comment: Please feel free to email He-Liang Huang with any comments, questions, suggestions or concern

Significance of Coronary Calcification for Prediction of Coronary Artery Disease and Cardiac Events Based on 64-Slice Coronary Computed Tomography Angiography

This work aims to validate the clinical significance of coronary artery calcium score (CACS) in predicting coronary artery disease(CAD) and cardiac events in 100 symptomatic patients (aged 37–87 years, mean 62.5, 81 males) that were followed up for a mean of 5 years. Our results showed that patients with CAD and cardiac events had significantly higher CACS than those without CAD and cardiac events, respectively. The corresponding data were 1450.42 ± 3471.24 versus 130 ± 188.29 (P 1000. Increased CACS (>100)was also associated with an increased frequency of multi-vessel disease. Nonetheless, 3 (20%) out of 15 patients with zero CACS had single-vessel disease. Significant correlation (P < 0.001) was observed between CACS and CAD on a vessel-based analysis for coronary arteries. It is concluded that CACS is significantly correlated with CAD and cardiac events

Evaluation of a novel saliva-based epidermal growth factor receptor mutation detection for lung cancer: A pilot study.

BackgroundThis article describes a pilot study evaluating a novel liquid biopsy system for non-small cell lung cancer (NSCLC) patients. The electric field-induced release and measurement (EFIRM) method utilizes an electrochemical biosensor for detecting oncogenic mutations in biofluids.MethodsSaliva and plasma of 17 patients were collected from three cancer centers prior to and after surgical resection. The EFIRM method was then applied to the collected samples to assay for exon 19 deletion and p.L858 mutations. EFIRM results were compared with cobas results of exon 19 deletion and p.L858 mutation detection in cancer tissues.ResultsThe EFIRM method was found to detect exon 19 deletion with an area under the curve (AUC) of 1.0 in both saliva and plasma samples in lung cancer patients. For L858R mutation detection, the AUC of saliva was 1.0, while the AUC of plasma was 0.98. Strong correlations were also found between presurgery and post-surgery samples for both saliva (0.86 for exon 19 and 0.98 for L858R) and plasma (0.73 for exon 19 and 0.94 for L858R).ConclusionOur study demonstrates the feasibility of utilizing EFIRM to rapidly, non-invasively, and conveniently detect epidermal growth factor receptor mutations in the saliva of patients with NSCLC, with results corresponding perfectly with the results of cobas tissue genotyping

Parametric study of density wave instability in parallel channels of a water-cooled blanket in a fusion reactor

In fusion reactors, many blanket concepts are designed with water as a coolant to transfer high-density heat from the fusion reaction out of the reactor core. The coolant temperature and pressure are maintained as the validated use in water-cooled fission reactors. However, the flow channel in a water-cooled blanket is independent of each other, and there is no flow mixing between coolant channels. Therefore, flow instability may occur in the independent parallel channels in a water-cooled blanket due to its unique structure and heat distribution, especially under the high heat flux caused by plasma rupture. In this study, the parametric analysis of density wave instability is performed using a thermal-hydraulic code developed for independent parallel channels based on the homogeneous model for the two-phase flow. The parallel-channel system in a water-cooled ceramic breeder (WCCB) blanket of the China Fusion Engineering Experimental Reactor (CFETR) is established for its first wall structure. A small disturbance is introduced into the system to determine if it is stable under different conditions. It is found that the channel number has no obvious influence on the prediction of the flow instability boundary. Therefore, the two-channel system is adopted to investigate the influence of different parameters, such as the pressure, resistance, flow rate, and inclination, on the flow instability boundary of the parallel-channel system in the CFETR WCCB blanket. The results show that flow instability occurs more easily in this study compared to the traditional instability analysis, especially under high-pressure conditions. In general, conditions of high pressure, large flow rate, and no inclination can stabilize the system, while the influence of resistance is quite different under different conditions of resistance and pressure. The research work indicates that more attention should be paid to the joint influence of different parameters for the water-cooled blanket during its design and operation