How to select patients and timing for rectal indomethacin to prevent post-ERCP pancreatitis: a systematic review and meta-analysis

Egger’s publication bias plot. (TIF 998 kb

Human performance analysis of processes for retrieving Beidou satellite navigation system during breakdown

Satellite navigation systems provide continuous, timely, and accurate signals of location, speed, and time to users all over the world. Although the running of these systems has become highly automated, the human operator is still vital for its continued operation, especially when certain equipment failures occur. In this paper, we examined 180 incidents of one particular type of equipment failure and the whole recovery process as recorded in the log files from a ground control center of the Beidou satellite navigation system. We extracted the information, including the technical description of the failure, the time when the fault occurred, the full recovery time, and the demographic information of the team members on the shift responsible for responding to the failure. We then transformed these information into the cognitive complexity of the task, time of day, shift handover period, and team skill composition. Multiple regression analysis showed that task complexity and shift handover were key predictors of recovery time. Time of day also influenced the recovery time, during midnight to 4 a.m., operators made longer responses. We also found that the fault handling processes could be improved if the team’s most adept member is more skillful at that role than in other teams. We discussed the theoretical and practical implication of this study

Shoggoth: Towards Efficient Edge-Cloud Collaborative Real-Time Video Inference via Adaptive Online Learning

This paper proposes Shoggoth, an efficient edge-cloud collaborative architecture, for boosting inference performance on real-time video of changing scenes. Shoggoth uses online knowledge distillation to improve the accuracy of models suffering from data drift and offloads the labeling process to the cloud, alleviating constrained resources of edge devices. At the edge, we design adaptive training using small batches to adapt models under limited computing power, and adaptive sampling of training frames for robustness and reducing bandwidth. The evaluations on the realistic dataset show 15%-20% model accuracy improvement compared to the edge-only strategy and fewer network costs than the cloud-only strategy.Comment: Accepted by 60th ACM/IEEE Design Automation Conference (DAC2023

Transcriptome-wide identification and characterization of miRNAs from Pinus densata

<p>Abstract</p> <p>Background</p> <p>MicroRNAs (miRNAs) play key roles in diverse developmental processes, nutrient homeostasis and responses to biotic and abiotic stresses. The biogenesis and regulatory functions of miRNAs have been intensively studied in model angiosperms, such as <it>Arabidopsis thaliana</it>, <it>Oryza sativa </it>and <it>Populus trichocarpa</it>. However, global identification of <it>Pinus densata </it>miRNAs has not been reported in previous research.</p> <p>Results</p> <p>Here, we report the identification of 34 conserved miRNAs belonging to 25 miRNA families from a <it>P. densata </it>mRNA transcriptome database using local BLAST and MIREAP programs. The primary and/or precursor sequences of 29 miRNAs were further confirmed by RT-PCR amplification and subsequent sequencing. The average value of the minimal folding free energy indexes of the 34 miRNA precursors was 0.92. Nineteen (58%) mature miRNAs began with a 5' terminal uridine residue. Analysis of miRNA precursors showed that 19 mature miRNAs were novel members of 14 conserved miRNA families, of which 17 miRNAs were further validated by subcloning and sequencing. Using real-time quantitative RT-PCR, we found that the expression levels of 7 miRNAs were more than 2-fold higher in needles than in stems. In addition, 72 <it>P. densata </it>mRNAs were predicted to be targets of 25 miRNA families. Four target genes, including a nodal modulator 1-like protein gene, two GRAS family transcription factor protein genes and one histone deacetylase gene, were experimentally verified to be the targets of 3 <it>P. densata </it>miRNAs, pde-miR162a, pde-miR171a and pde-miR482a, respectively.</p> <p>Conclusions</p> <p>This study led to the discovery of 34 conserved miRNAs comprising 25 miRNA families from <it>Pinus densata</it>. These results lay a solid foundation for further studying the regulative roles of miRNAs in the development, growth and responses to environmental stresses in <it>P. densata</it>.</p

Near-Term Quantum Computing Techniques: Variational Quantum Algorithms, Error Mitigation, Circuit Compilation, Benchmarking and Classical Simulation

Quantum computing is a game-changing technology for global academia, research centers and industries including computational science, mathematics, finance, pharmaceutical, materials science, chemistry and cryptography. Although it has seen a major boost in the last decade, we are still a long way from reaching the maturity of a full-fledged quantum computer. That said, we will be in the Noisy-Intermediate Scale Quantum (NISQ) era for a long time, working on dozens or even thousands of qubits quantum computing systems. An outstanding challenge, then, is to come up with an application that can reliably carry out a nontrivial task of interest on the near-term quantum devices with non-negligible quantum noise. To address this challenge, several near-term quantum computing techniques, including variational quantum algorithms, error mitigation, quantum circuit compilation and benchmarking protocols, have been proposed to characterize and mitigate errors, and to implement algorithms with a certain resistance to noise, so as to enhance the capabilities of near-term quantum devices and explore the boundaries of their ability to realize useful applications. Besides, the development of near-term quantum devices is inseparable from the efficient classical simulation, which plays a vital role in quantum algorithm design and verification, error-tolerant verification and other applications. This review will provide a thorough introduction of these near-term quantum computing techniques, report on their progress, and finally discuss the future prospect of these techniques, which we hope will motivate researchers to undertake additional studies in this field.Comment: Please feel free to email He-Liang Huang with any comments, questions, suggestions or concern

The efficacy of mitochondrial targeting antiresistant epirubicin liposomes in treating resistant leukemia in animals

Ying Men*, Xiao-Xing Wang*, Ruo-Jing Li, Yan Zhang, Wei Tian, Hong-Juan Yao, Rui-Jun Ju, Xue Ying, Jia Zhou, Nan Li, Liang Zhang, Yang Yu, Wan-Liang LuState Key Laboratory of Natural and Biomimetic Drugs, and School of Pharmaceutical Sciences, Peking University, Beijing, People&amp;#39;s Republic of China*These authors contributed equally to this manuscriptBackground: Multidrug resistance (MDR) of cancers can be circumvented by inducing programmed cell death, which is known as apoptosis. Mitochondria play a crucial role in apoptosis. Mitochondria-specific therapy would provide an efficient strategy for treating resistant cancers.Design and methods: A strategy was proposed here to overcome MDR by designing cancer mitochondria-specific drug-loaded liposomes, namely, antiresistant epirubicin mitosomes, aimed at treating resistant leukemia by targeting mitochondria. Evaluations were performed on human chronic leukemia K562, MDR K562/ADR cells, and female BALB/c nude mice xenografted with MDR K562/ADR cells. The liposomes were characterized through assays of cytotoxicity, mitochondrial targeting, caspase-9 and caspase-3, antitumor activities, and TUNEL (terminal deoxynucleotidyl transferase dUTP nick end labeling) analysis.Results: The average size of antiresistant epirubicin mitosomes was in the range of 105&amp;ndash;115 nm. Antiresistant epirubicin mitosomes were effective in inhibiting proliferation of MDR K562/ADR cells in vitro and selectively accumulated into the mitochondria. Caspase-9 and caspase-3 activity was increased after applying antiresistant epirubicin mitosomes. In xenografted resistant MDR K562/ADR tumor in nude mice, antiresistant tumor effect of antiresistant epirubicin mitosomes was evidently observed. Apoptotic inducing effects by antiresistant epirubicin mitosomes were noticeably evidenced via mitochondrial pathway.Conclusions: Antiresistant epirubicin mitosomes had significant inhibitory effect against resistant leukemia in vitro and in vivo, hence providing a promising strategy for improving therapeutic efficacy in resistant human leukemia.Keywords: mitosomes, mitochondria signaling pathway, nude mic

Effects of tobacco smoking on cardiovascular disease in patients with systemic lupus erythematosus: A systematic review and meta-analysis

BackgroundPatients with systemic lupus erythematosus (SLE) are at increased risk of cardiovascular disease (CVD) compared to the general population. However, little is known about the effects of tobacco smoking on CVD in patients with SLE.ObjectiveTo systematically review and summarize the available literature regarding the effects of tobacco smoking on developing CVD in patients with SLE.MethodsWe retrieved relevant studies from the following databases: PubMed, EMBASE, Web of Science and China National Knowledge Internet (CNKI) database. Two reviewers independently reviewed the eligible studies, assessed their validity, and extracted relevant data. Sensitivity and subgroup analyses were performed to distinguish sources of heterogeneity.ResultsA total of 10 studies, which comprised 6984 participants, were included in the analysis. The overall quality of evidence was rated as moderate to low. The smoking prevalence among CVD patients was 39.28% (271/690), which was higher than 31.36% (1974/6294) among non-CVD patients. Compared with never-smokers, the risk of developing CVD in current smokers was 1.42 (95% CI: 1.21–1.66). No significant publication bias was found in our meta-analysis.ConclusionsIn spite of the several negative results, this study found that current smokers with SLE have an increased risk of developing CVD, although most of the included studies were in low-to-moderate quality.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42022338109