3,452 research outputs found
Select a suitable treatment strategy for Crohn's disease
Crohnâs Disease (CD) is a chronic immune-mediated disorder with progressive and destructive course. Current guidelines on the treatment strategy still recommend a step-up approach with sequential prescription of corticosteroids and immunosuppressives. However, mounting
evidences manifested that top-down therapy with early administration of anti-TNF or combination of immunosuppressives can achieve more rapid and higher rate of mucosal healing and has the potential of modifying the natural course of disease. Therefore, who is suitable to accept and when to start anti-TNF therapy have attracted the attention of astroenterologists. And what benefit/risk can be expected from the two strategies should be carefully taken into account by clinicians. Age stratification, special patients, disease location and extension, genetic and serologic testing are predictors of disease progression and complication and thus guide a personalized treatment approach in CD. A definition of early CD has been proposed to select an algorithm for treatment of moderate-to-severe CD with a suitable strategy. To date mucosal healing has been widely used, the LĂ©mann score, which assesses the extent and severity of bowel damage at a specific time-point and over time, and is a new disability index
for patients with CD, will be considered as a
new endpoint for future studies of treatment
strategies. Besides medicines of the two strategies, surgery, vaccine, Leukocytapheresis and stem cell therapy are all effective therapeutic approaches which
lead to another thinking about what should they be putted in the conditional pyramid. However, we are trying to answer these questions
Methods of MicroRNA Promoter Prediction and Transcription Factor Mediated Regulatory Network
MicroRNAs (miRNAs) are short (~22 nucleotides) noncoding RNAs and disseminated throughout the genome, either in the intergenic regions or in the intronic sequences of protein-coding genes. MiRNAs have been proved to play important roles in regulating gene expression. Hence, understanding the transcriptional mechanism of miRNA genes is a very critical step to uncover the whole regulatory network. A number of miRNA promoter prediction models have been proposed in the past decade. This review summarized several most popular miRNA promoter prediction models which used genome sequence features, or other features, for example, histone markers, RNA Pol II binding sites, and nucleosome-free regions, achieved by high-throughput sequencing data. Some databases were described as resources for miRNA promoter information. We then performed comprehensive discussion on prediction and identification of transcription factor mediated microRNA regulatory networks
5,7-DihydrÂoxy-3,6,8-trimethoxyÂflavone
The title compound (systematic name: 5,7-dihydrÂoxy-3,6,8-trimethÂoxy-4H-chromen-4-one), C18H16O7, is a flavone that was isolated from Ainsliaea henryi. There are two molÂecules in the asymmetric unit, one of which has a disordered methÂoxy group [occupancy ratio 0.681â
(9):0.319â
(9)]. Both molÂecules have an intraÂmolecular OâHâŻO hydrogen bond. In the crystal, molÂecules are linked into OâHâŻO hydrogen-bonded chains parallel to [110]
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