Higgs compositeness in Sp(2N)\mathrm{Sp}(2N) gauge theories --- Resymplecticisation, scale setting and topology

As part of an ongoing programme to study $\mathrm{Sp}(2N)$ gauge theories as potential realisations of composite Higgs models, we consider the case of $\mathrm{Sp}(4)$ on the lattice, both as a pure gauge theory, and with two Dirac fermion flavors in the fundamental representation. In order to compare results between these two cases and maintain control of lattice artefacts, we make use of the gradient flow to set the scale of the simulations. We present some technical aspects of the simulations, including preliminary results for the scale setting in the two cases and results for the topological charge history.Comment: 8 pages, 6 figures; talk presented at the 35th International Symposium on Lattice Field Theory, 18-24 June 2017, Granada, Spai

Ethanol Extract of the Flower Chrysanthemum morifolium Augments Pentobarbital-Induced Sleep Behaviors: Involvement of Cl− Channel Activation

Dried Chrysanthemum morifolium flowers have traditionally been used in Korea for the treatment of insomnia. This study was performed to investigate whether the ethanol extract of Chrysanthemum morifolium flowers (EFC) enhances pentobarbital-induced sleep behaviors. EFC prolonged sleep time induced by pentobarbital similar to muscimol, a GABAA receptors agonist. EFC also increased sleep rate and sleep time when administrated with pentobarbital at a subhypnotic dosage. Both EFC and pentobarbital increased chloride (Cl−) influx in primary cultured cerebellar granule cells. EFC increased glutamic acid decarboxylase (GAD) expression levels, but had no effect on the expression of α1-, β2-, and γ2-subunits of the GABAA receptor in the hippocampus of a mouse brain. This is in contrast to treatment with pentobarbital, which showed decreased α1-subunit expression and no change in GAD expression. In conclusion, EFC augments pentobarbital-induced sleep behaviors; these effects may result from Cl− channel activation

Higgs compositeness in Sp(2N) gauge theories — Resymplecticisation, scale setting and topology

As part of an ongoing programme to study Sp(2N) gauge theories as potentialrealisations of composite Higgs models, we consider the case of Sp(4) on the lattice, bothas a pure gauge theory, and with two Dirac fermion flavors in the fundamental representation.In order to compare results between these two cases and maintain control oflattice artefacts, we make use of the gradient flow to set the scale of the simulations. Wepresent some technical aspects of the simulations, including preliminary results for thescale setting in the two cases and results for the topological charge history

MicroRNA-143 and-145 modulate the phenotype of synovial fibroblasts in rheumatoid arthritis

Fibroblast-like synoviocytes (FLSs) constitute a major cell subset of rheumatoid arthritis (RA) synovia. Dysregulation of microRNAs (miRNAs) has been implicated in activation and proliferation of RA-FLSs. However, the functional association of various miRNAs with their targets that are characteristic of the RA-FLS phenotype has not been globally elucidated. In this study, we performed microarray analyses of miRNAs and mRNAs in RA-FLSs and osteoarthritis FLSs (OA-FLSs), simultaneously, to validate how dysregulated miRNAs may be associated with the RA-FLS phenotype. Global miRNA profiling revealed that miR-143 and miR-145 were differentially upregulated in RA-FLSs compared to OA-FLSs. miR-143 and miR-145 were highly expressed in independent RA-FLSs. The miRNA-target prediction and network model of the predicted targets identified insulin-like growth factor binding protein 5 (IGFBP5) and semaphorin 3A (SEMA3A) as potential target genes downregulated by miR-143 and miR-145, respectively. IGFBP5 level was inversely correlated with miR-143 expression, and its deficiency rendered RA-FLSs more sensitive to TNFα stimulation, promoting IL-6 production and NF-κB activity. Moreover, SEMA3A was a direct target of miR-145, as determined by a luciferase reporter assay, antagonizing VEGF165-induced increases in the survival, migration and invasion of RA-FLSs. Taken together, our data suggest that enhanced expression of miR-143 and miR-145 renders RA-FLSs susceptible to TNFα and VEGF165 stimuli by downregulating IGFBP5 and SEMA3A, respectively, and that these miRNAs could be therapeutic targets. © 2017 KSBMB4

Sp(2N)Sp(2N) Yang-Mills theories on the lattice: scale setting and topology

We study Yang-Mills lattice theories with $Sp(N_c)$ gauge group, with $N_c=2N$, for $N=1,\,\cdots,\,4$. We show that if we divide the renormalised couplings appearing in the Wilson flow by the quadratic Casimir $C_2(F)$ of the $Sp(N_c)$ group, then the resulting quantities display a good agreement among all values of $N_c$ considered, over a finite interval in flow time. We use this scaled version of the Wilson flow as a scale-setting procedure, compute the topological susceptibility of the $Sp(N_c)$ theories, and extrapolate the results to the continuum limit for each $N_c$.Comment: 19 pages, 17 figures. v4: Typos corrected in eq. 35, Figures 3 and 4. Results unchange

Topological susceptibility, scale setting and universality from Sp(Nc)Sp(N_c) gauge theories

In this contribution, we report on our study of the properties of the Wilson flow and on the calculation of the topological susceptibility of $Sp(N_c)$ gauge theories for $N_c=2,\,4,\,6,\,8$. The Wilson flow is shown to scale according to the quadratic Casimir operator of the gauge group, as was already observed for $SU(N_c)$, and the commonly used scales $t_0$ and $w_0$ are obtained for a large interval of the inverse coupling for each probed value of $N_c$. The continuum limit of the topological susceptibility is computed and we conjecture that it scales with the dimension of the group. The lattice measurements performed in the $SU(N_c)$ Yang-Mills theories by several independent collaborations allow us to test this conjecture and to obtain a universal large-$N_c$ limit of the rescaled topological susceptibility.Comment: 9 pages, 3 figures. Proceeding for the 39th International Symposium on Lattice Field Theory, 8th-13th August 2022, Bonn, German

Chimera baryon spectrum in the Sp(4) completion of composite Higgs models

In strongly coupled gauge theories that serve as completions of composite Higgs models, the fermionic bound states formed by fermions (hyperquarks) transforming in different representations, called chimera baryons, could serve as top partners, by embedding of the Standard Model appropriately. We report our results on the spectrum of chimera baryons in the Sp(4) gauge theory with hyperquarks transforming in fundamental and two-index antisymmetric representations. For this study, we adopt the quenched approximation. We investigate the mass hierarchy between the lightest chimera baryons with different quantum numbers, as a function of the lattice parameters. Inspired by baryon chiral effective field theory, and the Akaike Information Criterion, we perform a first extrapolation to the continuum and massless-hyperquark limit.Comment: 8 pages, 2 figures, contribution to the proceedings of the 40th International Symposium on Lattice Field Theory (LATTICE2023), July 31st - August 4th, 2023, Fermi National Accelerator Laboratory, Batavia, Illinois, US