Method Of Real-Time Assessing Of Life Of Hp Heater Tube-Plate In Power Plants

AbstractIn large power plants, in order to improve safety and stability of HP heaters(High Pressure) in operation, thicker tubeplates are designed and made, which will lead to more thermal stress between tube-plate and end-cover, furthermore, will reduce the thermal fatigue life of HP heaters sharply. so it is necessary to monitor the thermal fatigue its life. However, at presently a large portion of methods carry on calculating or analyzing beforehand or afterwords, which make effect of analyzing life being less greatly. In this paper, according to the theory of calculation of thermal fatigue life, real-time gathering tube-plate's temperatures, and computing the life everyday, provide the basis of operating and maintaining in the power plate

Dietary Probiotic Bacillus licheniformis TC22 Increases Growth, Immunity, and Disease Resistance, against Vibrio splendidus Infection in Juvenile Sea Cucumbers Apostichopus japonicus

In this study we examined the effects of probiotic Bacillus licheniformis TC22 on growth, immunity, and disease resistance against Vibrio splendidus in juvenile sea cucumbers Apostichopus japonicus. For 30 days, sea cucumbers were fed diets with TC22 at 0 (control), 105, 107, and 109 CFU/g respectively. Results showed that dietary TC22 at 109 CFU/g significantly improved (P0.05). Dietary TC22 at 109 CFU/g significantly improved phagocytosis, and total nitric oxide synthase activity in sea cucumbers (P0.05). Respiratory burst in sea cucumbers fed dietary TC22 at 109 CFU/g was significantly higher than those fed dietary TC22 at 107 CFU/g (P<0.05). Cumulative mortality after V. splendidus challenge decreased significantly in the sea cucumbers fed with TC22 at 109 CFU/g (P<0.05). The present study confirmed dietary B. licheniformis TC22 at 109 CFU/g could significantly improve immunity and disease resistance in juvenile A. japonicus

Validation of the children international IgA nephropathy prediction tool based on data in Southwest China

BackgroundImmunoglobulin A nephropathy (IgAN) is one of the most common kidney diseases leading to renal injury. Of pediatric cases, 25%–30% progress into end-stage kidney disease (ESKD) in 20–25 years. Therefore, predicting and intervening in IgAN at an early stage is crucial. The purpose of this study was to validate the availability of an international predictive tool for childhood IgAN in a cohort of children with IgAN treated at a regional medical centre.MethodsAn external validation cohort of children with IgAN from medical centers in Southwest China was formed to validate the predictive performance of the two full models with and without race differences by comparing four measures: area under the curve (AUC), the regression coefficient of linear prediction (PI), survival analysis curves for different risk groups, and R2D.ResultsA total of 210 Chinese children, including 129 males, with an overall mean age of 9.43 ± 2.71 years, were incorporated from this regional medical center. In total, 11.43% (24/210) of patients achieved an outcome with a GFR decrease of more than 30% or reached ESKD. The AUC of the full model with race was 0.685 (95% CI: 0.570–0.800) and the AUC of the full model without race was 0.640 (95% CI: 0.517–0.764). The PI of the full model with race and without race was 0.816 (SE = 0.006, P &lt; 0.001) and 0.751 (SE = 0.005, P &lt; 0.001), respectively. The results of the survival curve analysis suggested the two models could not well distinguish between the low-risk and high-risk groups (P = 0.359 and P = 0.452), respectively, no matter the race difference. The evaluation of model fit for the full model with race was 66.5% and without race was 56.2%.ConclusionsThe international IgAN prediction tool has risk factors chosen based on adult data, and the validation cohort did not fully align with the derivation cohort in terms of demographic characteristics, clinical baseline levels, and pathological presentation, so the tool may not be highly applicable to children. We need to build IgAN prediction models that are more applicable to Chinese children based on their particular data

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival

Development and initial validation of the child intermittent Exotropia Questionnaire among child strabismus patients

Objectives: To translate the Child Intermittent Exotropia Questionnaire (Child-IXTQ) from English to Chinese and to evaluate its reliability and validity in Chinese childhood strabismus patients. Method: A consecutive sample of 143 child strabismus patients was recruited from the Department of Ophthalmology at a medical center in Southwest China. In addition, 100 visually normal adults and 100 patients with other eye diseases were recruited. The Brislin translation model was followed to develop the Chinese version of Child-IXTQ. Reliability was established using Cronbach's α and test-retest. Validity was established encompassing content validity, construct validity, convergent validity, criterion-related validity and discriminative validity. Results: The correlation coefficients between each item score with the total score ranged from 0.370 to 0.813. Two subscales were extracted by principal component analysis, with a content validity of 0.91. The correlation coefficients between two factor scores with the total score were 0.709 and 0.939. Criterion-related validity was estimated by the correlating the Child-IXTQ with the PedsQL 4.0, and the correlation coefficient was 0.522. In addition, the Child-IXTQ discriminated accurately between strabismus patients and normal children, or children with other eye diseases that possessed good discriminative validity. Cronbach's α coefficient for the internal consistency was 0.907 and the test-retest reliability was 0.962. Conclusions: Our study indicates that the Child-IXTQ is a reliable and valid instrument for assessing the health-related quality of life among children with strabismus

Real-Time Foreign Object and Production Status Detection of Tobacco Cabinets Based on Deep Learning

Visual inspection plays an important role in industrial production and can detect product defects at the production stage to avoid major economic losses. Most factories mainly rely on manual inspection, resulting in low inspection efficiency, high costs, and potential safety hazards. A real-time production status and foreign object detection framework for smoke cabinets based on deep learning is proposed in this paper. Firstly, the tobacco cabinet is tested for foreign objects based on the YOLOX, and if there is a foreign object, all production activities will be immediately stopped to avoid safety and quality problems. Secondly, the production status of tobacco cabinet is judged to determine whether it is in the feeding state by the YOLOX position locating method and canny threshold method. If it is not in the feeding state, then the three states of empty, full, and material status of the tobacco cabinet conveyor belt are judged based on the ResNet-18 image classification network. Ultilizing our proposed method, the accuracy of foreign object detection, feeding state detection and the conveyor belt of tobacco cabinet state detection are 99.13%, 96.36% and 95.30%, respectively. The overall detection time was less than 1 s. The experimental results show the effectiveness of our method. It has important practical significance for the safety, well-being and efficient production of cigarette factories