Victorian entertainments : "we are amused" : an exhibit illustrating Victorian entertainment.

Midwest Victorian Studies Association. Meeting (2007)published or submitted for publicationnot peer reviewe

Banks, insurance companies, and discrimination

This article examines some of the reasons why banks and insurance companies have been accused of discrimination, and shows that this is by and large a false accusation. Economic analysis demonstrates that racial discrimination is not a profit-maximizing strategy. Actually, unwise public policies are actually precluding many consumers from the market.redlining; financial regulation; unintended consequences

Measurement of the dynamic response of the CERN DC spark system and preliminary estimates of the breakdown turn-on time

The new High Repetition Rate (HRR) CERN DC Spark System has been used to investigate the current and voltage time structure of a breakdown. Simulations indicate that vacuum breakdowns develop on ns timescales or even less. An experimental benchmark for this timescale is critical for comparison to simulations. The fast rise time of breakdown may provide some explanation of the particularly high gradients achieved by low group velocity, and narrow bandwidth, accelerating structures such as the T18 and T24. Voltage and current measurements made with the previous system indicated that the transient responses measured were dominated by the inherent capacitances and inductances of the DC spark system itself. The bandwidth limitations of the HRR system are far less severe allowing rise times of approximately 12ns to be measured

The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly.

Previously, we identified ISRIB as a potent inhibitor of the integrated stress response (ISR) and showed that ISRIB makes cells resistant to the effects of eIF2α phosphorylation and enhances long-term memory in rodents (Sidrauski et al., 2013). Here, we show by genome-wide in vivo ribosome profiling that translation of a restricted subset of mRNAs is induced upon ISR activation. ISRIB substantially reversed the translational effects elicited by phosphorylation of eIF2α and induced no major changes in translation or mRNA levels in unstressed cells. eIF2α phosphorylation-induced stress granule (SG) formation was blocked by ISRIB. Strikingly, ISRIB addition to stressed cells with pre-formed SGs induced their rapid disassembly, liberating mRNAs into the actively translating pool. Restoration of mRNA translation and modulation of SG dynamics may be an effective treatment of neurodegenerative diseases characterized by eIF2α phosphorylation, SG formation, and cognitive loss