Dissipation Instability in the Accretion Disk

The model of a geometrically thin gaseous disk in the external gravitational potential is considered. The dinamics of small nonaxisymmetric perturbations in the plane of the accretion disk with dissipative effects is investigated. It is showed, that conditions of development and parameters of unstable oscillation modes in the opticaly thick accretion disk are strongly depended on the models of viscosity and opacity.Comment: Plain TeX, 6 pages, 2 figures (GIF), Submitted to Astron. Astrophys. Transaction

New Analytical Formula for Supercritical Accretion Flows

We examine a new family of global analytic solutions for optically thick accretion disks, which includes the supercritical accretion regime. We found that the ratio of the advection cooling rate, $Q_{\rm adv}$, to the viscous heating rate, $Q_{\rm vis}$, i.e., $f=Q_{\rm adv}/Q_{\rm vis}$, can be represented by an analytical form dependent on the radius and the mass accretion rate. The new analytic solutions can be characterized by the photon-trapping radius, \rtrap, inside which the accretion time is less than the photon diffusion time in the vertical direction; the nature of the solutions changes significantly as this radius is crossed. Inside the trapping radius, $f$ approaches $f \propto r^0$, which corresponds to the advection-dominated limit ($f \sim 1$), whereas outside the trapping radius, the radial dependence of $f$ changes to $f \propto r^{-2}$, which corresponds to the radiative-cooling-dominated limit. The analytical formula for $f$ derived here smoothly connects these two regimes. The set of new analytic solutions reproduces well the global disk structure obtained by numerical integration over a wide range of mass accretion rates, including the supercritical accretion regime. In particular, the effective temperature profiles for our new solutions are in good agreement with those obtained from numerical solutions. Therefore, the new solutions will provide a useful tool not only for evaluating the observational properties of accretion flows, but also for investigating the mass evolution of black holes in the presence of supercritical accretion flows.Comment: 14 pages, 7 figures, accepted for publication in the Astrophysical Journa

Radiation pressure instability driven variability in the accreting black holes

The time dependent evolution of the accretion disk around black hole is computed. The classical description of the $\alpha$-viscosity is adopted so the evolution is driven by the instability operating in the innermost radiation-pressure dominated part of the accretion disk. We assume that the optically thick disk always extends down to the marginally stable orbit so it is never evacuated completely. We include the effect of the advection, coronal dissipation and vertical outflow. We show that the presence of the corona and/or the outflow reduce the amplitude of the outburst. If only about half of the energy is dissipated in the disk (with the other half dissipated in the corona and carried away by the outflow) the outburst amplitude and duration are consistent with observations of the microquasar GRS 1915+105. Viscous evolution explains in a natural way the lack of direct transitions from the state C to the state B in color-color diagram of this source. Further reduction of the fraction of energy dissipated in the optically thick disk switches off the outbursts which may explain why they are not seen in all high accretion rate sources being in the Very High State.Comment: 31 pages, 14 figures; accepted to Ap

A Search for Aperiodic Millisecond Variability in Cygnus X-1

We have conducted a search for aperiodic millisecond variability in the integrated 1 to 25 keV X-ray region of Cyg X-1. We have examined HEAO A-1 archival data and Rossi X-ray Timing Explorer (RXTE) guest observer data for evidence of excess power above the Poisson noise floor using the relative integral power analysis and the Fourier transform method. Our results are in disagreement with the results of Meekins et al. (1984). We attribute the discrepancy to an instrumental effect for which Meekins et al.(1984) did not apply a correction. With the correction we see no evidence for excess power above 25 Hz in the HEAO A-1 data. Our analysis of RXTE data is in agreement with previously published results of different data sets and shows no sign of excess power above 30 Hz.Comment: 29 pages, 12 figures, to be submitted to Ap

The Ensemble Photometric Variability of ~25000 Quasars in the Sloan Digital Sky Survey

Using a sample of over 25000 spectroscopically confirmed quasars from the Sloan Digital Sky Survey, we show how quasar variability in the rest frame optical/UV regime depends upon rest frame time lag, luminosity, rest wavelength, redshift, the presence of radio and X-ray emission, and the presence of broad absorption line systems. The time dependence of variability (the structure function) is well-fit by a single power law on timescales from days to years. There is an anti-correlation of variability amplitude with rest wavelength, and quasars are systematically bluer when brighter at all redshifts. There is a strong anti-correlation of variability with quasar luminosity. There is also a significant positive correlation of variability amplitude with redshift, indicating evolution of the quasar population or the variability mechanism. We parameterize all of these relationships. Quasars with RASS X-ray detections are significantly more variable (at optical/UV wavelengths) than those without, and radio loud quasars are marginally more variable than their radio weak counterparts. We find no significant difference in the variability of quasars with and without broad absorption line troughs. Models involving multiple discrete events or gravitational microlensing are unlikely by themselves to account for the data. So-called accretion disk instability models are promising, but more quantitative predictions are needed.Comment: 41 pages, 21 figures, AASTeX, Accepted for publication in Ap

Pion production in the inner disk around Cygnus X-1

Neutron production via ^{4}He breakup and p(p, n{pi}^+)p is considered in the innermost region of an accretion disk surrounding a Kerr Black Hole. These reactions occur in a plasma in Wien equilibrium, where (radiatively produced) pair production equals annihilation. Cooling of the disk is assumed to be due to unsaturated inverse Comptonization of external soft photons and to the energy needed to ignite both nuclear reactions. Assuming matter composition of 90% Hydrogen and 10% He, it is shown that, close to the border of this region, neutron production is essentially from ^{4}He breakup. Close to the horizon, the contribution from p(p, n{pi}^+)p to the neutron production is comparable to that from the breakup. It is shown that the viscosity generated by the collisions of the accreting matter with the neutrons may drive stationary accretion, for accretion rates below a critical value. In this case, solution to the disk equations is double-valued and for both solutions protons overnumber the pairs. It is claimed that these solutions may mimic the states of high and low luminosity observed in Cygnus X-1 and related sources. This would be explained either by the coupling of thermal instability to the peculiar behavior of the viscosity parameter alpha with the ion temperature that may intermittently switch accretion off or by the impossibility of a perfect tuning for both thermal and pair equilibrium in the disk, a fact that forces the system to undergo a kind of limit cycle behavior around the upper solution.Comment: 23 pages, 11 figure

Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation

Although genome-wide association studies have identified over 100 risk loci that explain ~33% of familial risk for prostate cancer (PrCa), their functional effects on risk remain largely unknown. Here we use genotype data from 59,089 men of European and African American ancestries combined with cell-type-specific epigenetic data to build a genomic atlas of single-nucleotide polymorphism (SNP) heritability in PrCa. We find significant differences in heritability between variants in prostate-relevant epigenetic marks defined in normal versus tumour tissue as well as between tissue and cell lines. The majority of SNP heritability lies in regions marked by H3k27 acetylation in prostate adenoc7arcinoma cell line (LNCaP) or by DNaseI hypersensitive sites in cancer cell lines. We find a high degree of similarity between European and African American ancestries suggesting a similar genetic architecture from common variation underlying PrCa risk. Our findings showcase the power of integrating functional annotation with genetic data to understand the genetic basis of PrCa

Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation

Although genome-wide association studies have identified over 100 risk loci that explain similar to 33% of familial risk for prostate cancer (PrCa), their functional effects on risk remain largely unknown. Here we use genotype data from 59,089 men of European and African American ancestries combined with cell-type-specific epigenetic data to build a genomic atlas of single-nucleotide polymorphism (SNP) heritability in PrCa. We find significant differences in heritability between variants in prostate-relevant epigenetic marks defined in normal versus tumour tissue as well as between tissue and cell lines. The majority of SNP heritability lies in regions marked by H3k27 acetylation in prostate adenoc7arcinoma cell line (LNCaP) or by DNaseI hypersensitive sites in cancer cell lines. We find a high degree of similarity between European and African American ancestries suggesting a similar genetic architecture from common variation underlying PrCa risk. Our findings showcase the power of integrating functional annotation with genetic data to understand the genetic basis of PrCa

Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans

Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in 25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16 regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of correlated variation was observed at 39 regions; 35 of which are now described by a novel more significantly associated lead SNP, while the originally reported variant remained as the lead SNP only in 4 regions. We also confirmed two association signals in Europeans that had been previously reported only in East-Asian GWAS. Based on statistical evidence and linkage disequilibrium (LD) structure, we have curated and narrowed down the list of the most likely candidate causal variants for each region. Functional annotation using data from ENCODE filtered for PrCa cell lines and eQTL analysis demonstrated significant enrichment for overlap with bio-features within this set. By incorporating the novel risk variants identified here alongside the refined data for existing association signals, we estimate that these loci now explain ∼38.9% of the familial relative risk of PrCa, an 8.9% improvement over the previously reported GWAS tag SNPs. This suggests that a significant fraction of the heritability of PrCa may have been hidden during the discovery phase of GWAS, in particular due to the presence of multiple independent signals within the same regio