Directionally solidified superalloy

Cobalt-tungsten superalloy has improved stress rupture characteristics. Appropriate additions were made to this base alloy using microprobe analyses and a fractional factorial experiment

System architectures for telerobotic research

Several activities are performed related to the definition and creation of telerobotic systems. The effort and investment required to create architectures for these complex systems can be enormous; however, the magnitude of process can be reduced if structured design techniques are applied. A number of informal methodologies supporting certain aspects of the design process are available. More recently, prototypes of integrated tools supporting all phases of system design from requirements analysis to code generation and hardware layout have begun to appear. Activities related to system architecture of telerobots are described, including current activities which are designed to provide a methodology for the comparison and quantitative analysis of alternative system architectures

`The frozen accident' as an evolutionary adaptation: A rate distortion theory perspective on the dynamics and symmetries of genetic coding mechanisms

We survey some interpretations and related issues concerning the frozen hypothesis due to F. Crick and how it can be explained in terms of several natural mechanisms involving error correction codes, spin glasses, symmetry breaking and the characteristic robustness of genetic networks. The approach to most of these questions involves using elements of Shannon's rate distortion theory incorporating a semantic system which is meaningful for the relevant alphabets and vocabulary implemented in transmission of the genetic code. We apply the fundamental homology between information source uncertainty with the free energy density of a thermodynamical system with respect to transcriptional regulators and the communication channels of sequence/structure in proteins. This leads to the suggestion that the frozen accident may have been a type of evolutionary adaptation

An experimental measurement of galactic cosmic radiation dose in conventional aircraft between San Francisco and London compared to theoretical values for conventional and supersonic aircraft

These direct measurements are in fair agreement with computations made using a program which considers both basic cosmic ray atmospheric physics and the focusing effect of the earth's magnetic field. These measurements also agree with those made at supersonic jet aircraft altitudes in Rb-57 aircraft. It is concluded that experiments and theory show that the doses received at conventional jet aircraft altitudes are slightly higher than those encountered in supersonic flights at much higher altitudes

Modified eutectic alloys for high temperature service Six month progress report

Eutectic alloys of cobalt and nickel modified by tungsten for use at high temperature

Dynamics of living cells in a cytomorphological state space.

Cells are nonequilibrium systems that exchange matter and energy with the environment to sustain their metabolic needs. The nonequilibrium nature of this system presents considerable challenges to developing a general theory describing its behavior; however, when studied at appropriate spatiotemporal scales, the behavior of ensembles of nonequilibrium systems can resemble that of a system at equilibrium. Here we apply this principle to a population of cells within a cytomorphological state space and demonstrate that cellular transition dynamics within this space can be described using equilibrium formalisms. We use this framework to map the effective energy landscape underlying the cytomorphological state space of a population of mouse embryonic fibroblasts (MEFs) and identify topographical nonuniformity in this space, indicating nonuniform occupation of cytomorphological states within an isogenic population. The introduction of exogenous apoptotic agents fundamentally altered this energy landscape, inducing formation of additional energy minima that correlated directly with changes in sensitivity to apoptosis induction. An equilibrium framework allows us to describe the behavior of an ensemble of single cells, suggesting that although cells are complex nonequilibrium systems, the application of formalisms derived from equilibrium thermodynamics can provide insight into the basis of nongenetic heterogeneities within cell populations, as well as the relationship between cytomorphological and functional heterogeneity

Modified eutectic alloys for high temperature service Semiannual progress report

Structural modification of high temperature superalloy

An Exploration of Young People’s Experiences of a Participatory Project

Listening to and involving children and young people (CYP) in decision-making and services that affect them has become increasingly important. Since the 1990s, there has been a rise in participatory approaches and research with CYP. Both models of participatory research and practice in this area are being developed. This research aims to enhance developments in participatory research with CYP by learning from the experiences, perspectives and accounts of CYP who have experienced a participatory project. The participatory research project that participants in this research experienced was The Verbatim Formula (TVF), a creative residential workshop for care-experienced young people, using applied art practices to investigate their experiences of care and plans for their futures. This research used an Interpretative Phenomenological Analysis (IPA) approach to explore how the young people taking part in TVF, experienced the project. A sample of five young people, ranging from the age of 16 to 21 years old took part in face-to-face semi-structured interviews. The findings of this research focused on three main themes: the young people made sense of their experiences of the project through participating; learning and interpersonal relationships. The richness and power of how young people experienced the project highlighted the possibilities of what can be gained by asking CYP about their experiences and how these could develop participatory research practices and thinking. There are also implications for educational psychology practice and the potential for future research with Educational Psychologists is outlined

Discrimination by Gender and Disability Status: Do Worker Perceptions Match Statistical Measures?

We explore whether perceptions of discrimination are related to ordinary statistical measures. The majority of disabled respondents report feeling some discrimination due to their disability, the majority of women feel some discrimination because of their gender, and a surprising number of men also report some discrimination. We do not find a strong link between perceptions of discrimination and measured discrimination perhaps because those who perceive discrimination feel that it occurs along other dimensions than pay. However, we do find a connection between whether a person feels his or her income is inadequate and measured discrimination for all groups studied