43,630 research outputs found
Understanding the different rotational behaviors of No and No
Total Routhian surface calculations have been performed to investigate
rapidly rotating transfermium nuclei, the heaviest nuclei accessible by
detailed spectroscopy experiments. The observed fast alignment in No
and slow alignment in No are well reproduced by the calculations
incorporating high-order deformations. The different rotational behaviors of
No and No can be understood for the first time in terms of
deformation that decreases the energies of the
intruder orbitals below the N=152 gap. Our investigations reveal the importance
of high-order deformation in describing not only the multi-quasiparticle states
but also the rotational spectra, both providing probes of the single-particle
structure concerning the expected doubly-magic superheavy nuclei.Comment: 5 pages, 4 figures, the version accepted for publication in Phys.
Rev.
Task oriented nonlinear control laws for telerobotic assembly operations
The goal of this research is to achieve very intelligent telerobotic controllers which are capable of receiving high-level commands from the human operator and implementing them in an adaptive manner in the object/task/manipulator workspace. Initiatives by the authors at Integrated Systems, Inc. to identify and develop the key technologies necessary to create such a flexible, highly programmable, telerobotic controller are presented. The focus of the discussion is on the modeling of insertion tasks in three dimensions and nonlinear implicit force feedback control laws which incorporate tool/workspace constraints. Preliminary experiments with dual arm beam assembly in 2-D are presented
Review of geographical stocks of tropical dolphins (Stenella spp. and Delphinus delphis) in the eastern Pacific
Information on geographical variation is reviewed for Stenella attenuata, S. longirostris, S. coeruleoalba, and
Delphinus delphis in the eastern tropical Pacific, and boundaries for potential management units are proposed.
National Marine Fisheries Service and Inter-American Tropical Tuna Commission sighting records made from 1979 to 1983 which were outside boundaries used in a 1979 assessment were examined for validity. Tagging returns and morphological data were also analyzed. Several stock ranges are expanded or combined. Three management units are proposed for S. attenuata: the coastal, northern offshore, and southern offshore spoiled dolphins. Four management units are proposed for S. longirostris: the Costa Rican, eastern, northern whitebelly, and southern whitebelly spinner dolphins. Two provisional management units are proposed for S. coeruleoalba: the northern and southern striped dolphins. Five management units (two of which are provisional) are proposed for D. delphis: the Baja neritic, northern, central, southern, and Guerrero common dolphins. Division into management units was based on morphological stock differences and distributional breaks. (PDF file contains 34 pages.
Effects of high order deformation on superheavy high- isomers
Using, for the first time, configuration-constrained potential-energy-surface
calculations with the inclusion of deformation, we find remarkable
effects of the high order deformation on the high- isomers in No,
the focus of recent spectroscopy experiments on superheavy nuclei. For shapes
with multipolarity six, the isomers are more tightly bound and,
microscopically, have enhanced deformed shell gaps at and . The
inclusion of deformation significantly improves the description of
the very heavy high- isomers.Comment: 5 pages, 4 figures, 1 table, the version to appear in Phys. Rev.
Quantitative Analysis of Candida Cell Wall Components by Flow Cytometrywith Triple-Fluorescence Staining
This work was supported by the European Commission within the FP7 Framework Programme [Fungitect-Grant No 602125]. We also thank Thomas Sauer, Vienna Biocenter Campus (VBC), Austria, for technical support at the FACS facility of the MFPL, Karl Kuchler, MFPL-Department of Medical Biochemistry, Medical University of Vienna, Max F. Perutz Laboratories, Campus Vienna Biocenter, Vienna, Austria and Ernst Thuer, Centre for Genomic Regulation, Barcelona, Spain, for advice on statistical approaches. Neil Gow acknowledges the support of the Wellcome Trust and the MRC Centre for Medical MycologyPeer reviewedPublisher PD
Membrane Type 1 Matrix Metalloproteinase Regulates Monocyte Migration and Collagen Destruction in Tuberculosis
Tuberculosis (TB) remains a global pandemic and drug resistance is rising. Multicellular granuloma formation is the pathological hallmark of Mycobacterium tuberculosis infection. The membrane type 1 matrix metalloproteinase (MT1-MMP or MMP-14) is a collagenase that is key in leukocyte migration and collagen destruction. In patients with TB, induced sputum MT1-MMP mRNA levels were increased 5.1-fold compared with matched controls and correlated positively with extent of lung infiltration on chest radiographs (r = 0.483; p < 0.05). M. tuberculosis infection of primary human monocytes increased MT1-MMP surface expression 31.7-fold and gene expression 24.5-fold. M. tuberculosis-infected monocytes degraded collagen matrix in an MT1-MMP-dependent manner, and MT1-MMP neutralization decreased collagen degradation by 73%. In human TB granulomas, MT1-MMP immunoreactivity was observed in macrophages throughout the granuloma. Monocyte-monocyte networks caused a 17.5-fold increase in MT1-MMP surface expression dependent on p38 MAPK and G protein-coupled receptor-dependent signaling. Monocytes migrating toward agarose beads impregnated with conditioned media from M. tuberculosis-infected monocytes expressed MT1-MMP. Neutralization of MT1-MMP activity decreased this M. tuberculosis network-dependent monocyte migration by 44%. Taken together, we demonstrate that MT1-MMP is central to two key elements of TB pathogenesis, causing collagen degradation and regulating monocyte migration
Electric field control of multiferroic domains in NiVO imaged by X-ray polarization enhanced topography
The magnetic structure of multiferroic NiVO has been investigated
using non-resonant X-ray magnetic scattering. Incident circularly polarized
X-rays combined with full polarization analysis of the scattered beam is shown
to yield high sensitivity to the components of the cycloidal magnetic order,
including their relative phases. New information on the magnetic structure in
the ferroelectric phase is obtained, where it is found that the magnetic
moments on the "cross-tie" sites are quenched relative to those on the "spine"
sites. This implies that the onset of ferroelectricity is associated mainly
with spine site magnetic order. We also demonstrate that our technique enables
the imaging of multiferroic domains through polarization enhanced topography.
This approach is used to image the domains as the sample is cycled by an
electric field through its hysteresis loop, revealing the gradual switching of
domains without nucleation.Comment: 9 pages, 6 figure
Independent component analysis of interictal fMRI in focal epilepsy: comparison with general linear model-based EEG-correlated fMRI
The general linear model (GLM) has been used to analyze simultaneous EEGâfMRI to reveal BOLD changes linked to interictal epileptic discharges (IED) identified on scalp EEG. This approach is ineffective when IED are not evident in the EEG. Data-driven fMRI analysis techniques that do not require an EEG derived model may offer a solution in these circumstances. We compared the findings of independent components analysis (ICA) and EEG-based GLM analyses of fMRI data from eight patients with focal epilepsy. Spatial ICA was used to extract independent components (IC) which were automatically classified as either BOLD-related, motion artefacts, EPI-susceptibility artefacts, large blood vessels, noise at high spatial or temporal frequency. The classifier reduced the number of candidate IC by 78%, with an average of 16 BOLD-related IC. Concordance between the ICA and GLM-derived results was assessed based on spatio-temporal criteria. In each patient, one of the IC satisfied the criteria to correspond to IED-based GLM result. The remaining IC were consistent with BOLD patterns of spontaneous brain activity and may include epileptic activity that was not evident on the scalp EEG. In conclusion, ICA of fMRI is capable of revealing areas of epileptic activity in patients with focal epilepsy and may be useful for the analysis of EEGâfMRI data in which abnormalities are not apparent on scalp EEG
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