138 research outputs found
Health cost inflation in New Zealand
A large personal injury insurance organisation was originally created to help fund work place injuries. Since then it has expanded into a “no fault non-optional personal injury protection insurance” scheme. The scheme is available to all New Zealanders, and any visitors to New Zealand. It is funded through the collection of several levies. The collection of these levies funds treatment costs, wage compensation, injury prevention programmes and more. As a person who works on the frontlines for this organisation, the author fields a lot of questions, in particular questions surrounding surcharges, and costs customers have had to pay to their treatment providers. This leads the research to the research question, “Are customers of this organisation having a financial burden placed on them when receiving treatment?” The researcher decided to look into three specific services and the contribution they receive from this organisation and charge to their customers, compared to the prices they charge for private consultations. This research was done only in the Waikato, and across three service types. It could be replicated with more services, and across other cities or countries. The research currently indicates that GPs seem to be charging this organisation’s customers a fair amount compared to private visits, whereas physiotherapists and radiologists are not
Reflections on creative methodologies for health technology research, and the iterative process between research and design
Web based home hazard modification app for falls prevention: the views of those at risk of falling and their carers
FLAVOR PREFERENCE AND EFFICACY OF VARIABLE DOSE ONTARIO RABIES VACCINE BAIT (ONRAB) DELIVERY IN STRIPED SKUNKS (\u3ci\u3eMEPHITIS MEPHITIS\u3c/i\u3e)
In North America, terrestrial wildlife rabies control is achieved by oral rabies vaccination programs that principally target mesocarnivores. Success at rabies control in striped skunks (Mephitis mephitis) has been more limited and may require additional enhancements to existing bait products or novel bait designs and attractants. We evaluated preference among captive striped skunks for six different flavors of placebo Ontario Rabies Vaccine Bait (ONRAB®) ‘‘Ultralite’’ Baits (Artemis Technologies, Guelph, Ontario, Canada). Different doses and delivery methods of ONRAB vaccine were tested for efficacy in a subsequent experiment with the same skunks. Cheese-, egg-, and chicken flavored baits were preferred over plain-flavored baits, but a strong preference for a singular flavor was not observed. Vaccine efficacy of 80–100% was observed among skunks challenged at 335 d postvaccination across a log range of doses tested by a direct instillation into the oral cavity route, respectively (109.3 - 1010.2 median tissue culture infective doses), in contrast to more-limited efficacy by bait delivery. Our results extended the duration of ONRAB vaccine efficacy in skunks and suggested that there may be limited flexibility to alter vaccine titer and volume in novel bait designs for skunks
FLAVOR PREFERENCE AND EFFICACY OF VARIABLE DOSE ONTARIO RABIES VACCINE BAIT (ONRAB) DELIVERY IN STRIPED SKUNKS (\u3ci\u3eMEPHITIS MEPHITIS\u3c/i\u3e)
In North America, terrestrial wildlife rabies control is achieved by oral rabies vaccination programs that principally target mesocarnivores. Success at rabies control in striped skunks (Mephitis mephitis) has been more limited and may require additional enhancements to existing bait products or novel bait designs and attractants. We evaluated preference among captive striped skunks for six different flavors of placebo Ontario Rabies Vaccine Bait (ONRAB®) ‘‘Ultralite’’ Baits (Artemis Technologies, Guelph, Ontario, Canada). Different doses and delivery methods of ONRAB vaccine were tested for efficacy in a subsequent experiment with the same skunks. Cheese-, egg-, and chicken flavored baits were preferred over plain-flavored baits, but a strong preference for a singular flavor was not observed. Vaccine efficacy of 80–100% was observed among skunks challenged at 335 d postvaccination across a log range of doses tested by a direct instillation into the oral cavity route, respectively (109.3 - 1010.2 median tissue culture infective doses), in contrast to more-limited efficacy by bait delivery. Our results extended the duration of ONRAB vaccine efficacy in skunks and suggested that there may be limited flexibility to alter vaccine titer and volume in novel bait designs for skunks
Efficacy of Ontario Rabies Vaccine Baits (ONRAB) against rabies infection in raccoons
In the US, rabies lyssavirus (RABV) only circulates in wildlife species and the most significant reservoir from a public and animal health perspective is the raccoon (Procyon lotor). Management of wildlife rabies relies principally on oral rabies vaccination (ORV) strategies using vaccine-laden bait delivery to freeranging target hosts, in order to reduce the susceptible population to prevent the spread of and eliminate RABV circulation. Our objective was to evaluate efficacy of the Ontario Rabies Vaccine Bait (ONRAB) against a lethal RABV challenge in captive raccoons. Sham or live vaccine baits were offered to 50 raccoons and efficacy was evaluated in 46, split into two trials of 17 and 29 raccoons. Raccoons were challenged with a lethal dose of RABV 180 days post-vaccination and observed for 90 days post-infection. Raccoon bait interactions were assigned increasing integer scores for approach, oral manipulation, puncture, and consumption behaviors. Higher bait interaction scores were observed in the fall compared to the spring trial, indicating that more raccoons consumed baits in the fall. Although animal age did not explain variation in bait interaction scores, the geometric mean rabies virus antibody titers among juvenile vaccinates were higher than adults at all pre-challenge time points. The prevented fraction associated with ONRAB delivery was 0.73 (8/11, 95% CI 0.39–0.94) in the spring trial and 0.91 (21/23, 95% CI 0.72–0.99) in the fall trial. All sham-vaccinated raccoons (12/12) succumbed to rabies infection, in contrast to 15% (5/34) mortality among vaccinated raccoons. Our results indicate a high efficacy of ONRAB bait vaccination in protecting adult and juvenile raccoons against RABV infection for a minimum of six months. These data complement experimental field trials that have also demonstrated the potential of ONRAB for the control and prevention of RABV circulation in free-ranging raccoon populations in the US
Impact of Experiencing Misrecognition by Teachable Agents on Learning and Rapport
While speech-enabled teachable agents have some advantages over typing-based
ones, they are vulnerable to errors stemming from misrecognition by automatic
speech recognition (ASR). These errors may propagate, resulting in unexpected
changes in the flow of conversation. We analyzed how such changes are linked
with learning gains and learners' rapport with the agents. Our results show
they are not related to learning gains or rapport, regardless of the types of
responses the agents should have returned given the correct input from learners
without ASR errors. We also discuss the implications for optimal error-recovery
policies for teachable agents that can be drawn from these findings.Comment: Accepted to AIED 202
EVIDENCE OF TWO COCIRCULATING CANINE DISTEMPER VIRUS STRAINS IN MESOCARNIVORES FROM NORTHERN COLORADO, USA
Canine distemper virus (CDV) is a highly contagious pathogen that principally infects wildlife and domestic carnivores. Peridomestic species such as raccoons (Procyon lotor) experience outbreaks with high mortality. Clinical signs of infection include anorexia, fever, respiratory infection, and neurologic complications. Although not zoonotic, CDV poses a high risk to unvaccinated domestic animals and the conservation of endangered species. During 2013–16, we opportunistically collected wild and domestic carnivore specimens through a rabies surveillance program in northern Colorado, US. Brainstem and cerebellar tissue samples were independently tested for rabies and CDV by fluorescent antibody test. We tested a total of 478 animals for CDV, comprised of 10 wild and domestic carnivore species. A total of 15% (72/478) of all animals sampled tested positive for CDV, consisting of 24% (71/300) of raccoons and 4% (1/26) of coyotes (Canis latrans), but coinfection with rabies virus was not observed among CDV-positive animals. We extracted RNA from positive tissues, and a reverse-transcription PCR was used to create complementary DNA. We amplified and sequenced the hemagglutinin gene from 60 CDV-positive tissues, and a median joining network and maximum likelihood phylogenetic tree revealed two major lineages among samples. Phylogenetic analysis indicated that our sequences were most similar to the America-2 (n=55) and the America-3 (n=5) CDV lineages circulating in North America. Our results indicated two distinct and distantly related clades of CDV overlapping geographically and temporally among raccoon populations in northern Colorado
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