This demented land: representations of madness in contemporary Scottish fiction

This thesis analyses representations of madness and mental illness in Scottish fiction from 1979. I begin by exploring the development of the relationship between Scottish identity on one hand, and madness and unreason on the other, arguing that in criticism of Scottish fiction, representations of schizoid experience are often understood as contributing to discourses centring on Scottish identity and the construction of a Scottish literary tradition. The contention of this thesis is that reading madness in this way often simplifies the complex relationship between representations of psychosis and other forms of unreason on the one hand, and political, philosophical and theoretical structures on the other. Its purpose is to proffer a corrective to this simplification and to develop a thematic mode of approaching Scottish writing. This thesis analyses representations of madness in the work of Alasdair Gray, Janice Galloway, Alan Warner, Elspeth Barker, Bella Bathurst, and Alice Thompson. In Chapter One, I discuss the relationship between madness, creativity and autonomy in Gray's Lanark, 1982, Janine and Poor Things; Chapter Two deals with the significance of traumatic experience to Janice Galloway's The Trick Is to Keep Breathing and Foreign Parts, and the environmental concerns of Alan Warner's Morvern novels form the basis of Chapter Three. The second section of the thesis deals with representations of madness in the work of three women authors. In my fourth chapter, I attempt to formulate an approach to Gothic stylistics by comparing the function of madness and other Gothic traits in Barker's O Caledonia and Bathurst's Special. The final chapter approaches Alice Thompson's enigmatic work by theorising how she aestheticises her concern with the limits of rational knowledge in The Existential Detective, The Falconer, and Pandora's Box. The purpose of this thesis is to place the writing of madness in Scotland within the context of broad literary and philosophical traditions. This contributes to the field of Scottish literary studies by widening its scope to think through questions raised by the representation of madness. In particular, it allows for the analysis of the ways these writers distinguish between madness and sanity, the nature of the distinction between reason and unreason, and the implications these questions have for wider epistemological inquiries into the nature of knowledge and narration. In doing so, it allows for engagement with current debates in literary theory, particularly feminist and ecologically-orientated criticism, affect theory and trauma, as well as asking how a concern with literary style and genre can contribute to readings of unreason

Impact of fatigue on work productivity and health-related job loss

We acknowledge the contribution of Jisha Babu in undertaking administrative activities in relation to the manuscript. We wish to thank Professor Keith Palmer for his work incepting the HEAF cohort as well as the staff of the MRC LEC who provided data entry and computing support (notably Vanessa Cox). Finally, we would like to thank the HEAF participants for giving their time so generously to participate in the study.Peer reviewe

The social support and service needs of Australia’s ageing Greek migrants: a pilot project

This article explores the social support and service needs of Greek-speakers in Australia who migrated as young adults mostly in the 1940s and 1950s. The article reports the findings of a pilot research project initiated by the Modern Greek department at Flinders University in conjunction with social, health and ageing researchers. Focus groups and interviews were held in Adelaide and Darwin in 2010 with older Greek-speakers born in Greece and Cyprus; a survey of service organisations was also conducted. All older Greeks chose to be interviewed in Greek. They reported using a range of formal services, although some were confused about how to access services and lacked awareness of services. Interrupted primary education had resulted in low reading proficiency in Greek, while settlement experiences had contributed to low proficiency in reading, writing and speaking English. These were major barriers to accessing services with no Greek-speaking staff. In line with cultural expectations, a key support role was played by adult children, while some Greek-speaking GPs and MPs also mediated information and service access. Many older Greeks appear to be living independently in the community, but this is only possible because of high levels of informal support from close family. Those without children may therefore be more vulnerable to social isolation. The Modern Greek researchers who were integral members of the research team acted as ‘insiders’ who shared the culture and language of interviewees. Since all interviewees chose to be interviewed in Modern Greek, the ability to conduct interviews in Greek clearly enabled their participation, whereas they may have declined to participate had interviews only been available in English. At the same time, the non-Greek researchers provided a critical ‘outsider’ view which strengthened the data analysis and interpretation. We conclude that this project has demonstrated the important role that Modern Greek academics can play in research on social and health issues among the Greek diaspora

Morbidities Among Older Workers And Work Exit : The Heaf Cohort

Funding: The HEAF study is funded by grant awards from Versus Arthritis (formerly Arthritis Research UK) (19817 and 20665) and the Medical Research Council programme grant (MC_UU_12011/5); and the Economic and Social Research Council and Medical Research Council jointly (ES/L002663/1); the study is coordinated by the MRC Lifecourse Epidemiology Unit, Southampton. GN and CHL receive financial support from the MRC Versus Arthritis Centre for Musculoskeletal Health and Work. Acknowledgements: We wish to thank Professor Keith Palmer for his work incepting the HEAF cohort and Dr Stephen Duffield for his contribution to the coding of the CPRD data. Also, we are grateful to the Clinical Practice Research Datalink and the 24 general practices that supported data collection, the staff of the MRC Lifecourse Epidemiology Unit who provided data entry and computing support (notably Vanessa Cox). Finally, we thank the HEAF participants for giving their time so generously to participate in the study.Peer reviewedPostprin

The Social Support and Service Needs of Australia’s Ageing Greek Migrants: A Pilot Project

This article explores the social support and service needs of Greek-speakers in Australia who migrated as young adults mostly in the 1940s and 1950s. The article reports the findings of a pilot research project initiated by the Modern Greek department at Flinders University in conjunction with social, health and ageing researchers. Focus groups and interviews were held in Adelaide and Darwin in 2010 with older Greek-speakers born in Greece and Cyprus; a survey of service organisations was also conducted. All older Greeks chose to be inter - viewed in Greek. They reported using a range of formal services, although some were confused about how to access services and lacked awareness of services. Interrupted primary education had resulted in low reading proficiency in Greek, while settlement experiences had contributed to low proficiency in reading, writing and speaking English. These were major barriers to accessing services with no Greek-speaking staff. In line with cultural expectations, a key support role was played by adult children, while some Greek-speaking GPs and MPs also mediated information and service access. Many older  Greeks appear to be living independently in the community, but this is only possible because of high levels of informal support from close family. Those without children may therefore be more vulnerable to social isolation. The Modern Greek researchers who were integral members of the research team acted as “insiders” who shared the culture and language of interviewees. Since all interviewees chose to be interviewed in Modern Greek, the ability to conduct interviews in Greek clearly enabled their participation, whereas they may have declined to participate had interviews only been available in English. At the same time, the non-Greek researchers provided a critical “outsider” view which strengthened the data analysis and interpretation. We conclude that this project has demonstrated the important role that Modern Greek academics can play in research on social and health issues among the Greek diaspora

The Alzheimer's-related amyloid beta peptide is internalised by R28 neuroretinal cells and disrupts the microtubule associated protein 2 (MAP-2)

Age-related Macular Degeneration (AMD) is a common, irreversible blinding condition that leads to the loss of central vision. AMD has a complex aetiology with both genetic as well as environmental risks factors, and share many similarities with Alzheimer's disease. Recent findings have contributed significantly to unravelling its genetic architecture that is yet to be matched by molecular insights. Studies are made more challenging by observations that aged and AMD retinas accumulate the highly pathogenic Alzheimer's-related Amyloid beta (A?) group of peptides, for which there appears to be no clear genetic basis. Analyses of human donor and animal eyes have identified retinal A? aggregates in retinal ganglion cells (RGC), the inner nuclear layer, photoreceptors as well as the retinal pigment epithelium. A? is also a major drusen constituent; found correlated with elevated drusen-load and age, with a propensity to aggregate in retinas of advanced AMD. Despite this evidence, how such a potent driver of neurodegeneration might impair the neuroretina remains incompletely understood, and studies into this important aspect of retinopathy remains limited. In order to address this we exploited R28 rat retinal cells which due to its heterogeneous nature, offers diverse neuroretinal cell-types in which to study the molecular pathology of A?. R28 cells are also unaffected by problems associated with the commonly used RGC-5 immortalised cell-line, thus providing a well-established model in which to study dynamic A? effects at single-cell resolution. Our findings show that R28 cells express key neuronal markers calbindin, protein kinase C and the microtubule associated protein-2 (MAP-2) by confocal immunofluorescence which has not been shown before, but also calretinin which has not been reported previously. For the first time, we reveal that retinal neurons rapidly internalised A?1-42, the most cytotoxic and aggregate-prone amongst the A? family. Furthermore, exposure to physiological amounts of A?1-42 for 24 h correlated with impairment to neuronal MAP-2, a cytoskeletal protein which regulates microtubule dynamics in axons and dendrites. Disruption to MAP-2 was transient, and had recovered by 48 h, although internalised A? persisted as discrete puncta for as long as 72 h. To assess whether A? could realistically localise to living retinas to mediate such effects, we subretinally injected nanomolar levels of oligomeric A?1-42 into wildtype mice. Confocal microscopy revealed the presence of focal A? deposits in RGC, the inner nuclear and the outer plexiform layers 8 days later, recapitulating naturally-occurring patterns of A? aggregation in aged retinas. Our novel findings describe how retinal neurons internalise A? to transiently impair MAP-2 in a hitherto unreported manner. MAP-2 dysfunction is reported in AMD retinas, and is thought to be involved in remodelling and plasticity of post-mitotic neurons. Our insights suggest a molecular pathway by which this could occur in the senescent eye leading to complex diseases such as AMD

Associations of sickness absence for pain in the low back, neck and shoulders with wider propensity to pain

Objectives: To explore the association of sickness absence ascribed to pain at specific anatomical sites with wider propensity to musculoskeletal pain.Methods: As part of the CUPID (Cultural and Psychosocial Influences on Disability) study, potential risk factors for sickness absence from musculoskeletal pain were determined for 11 922 participants from 45 occupational groups in 18 countries. After approximately 14 months, 9119 (78%) provided follow-up information about sickness in the past month because of musculoskeletal pain, including 8610 who were still in the same job. Associations with absence for pain at specific anatomical sites were assessed by logistic regression and summarised by ORs with 95% CIs.Results: 861 participants (10%) reported absence from work because of musculoskeletal pain during the month before follow-up. After allowance for potential confounders, risk of absence ascribed entirely to low back pain (n=235) increased with the number of anatomical sites other than low back that had been reported as painful in the year before baseline (ORs 1.6 to 1.7 for ≥4 vs 0 painful sites). Similarly, associations with wider propensity to pain were observed for absence attributed entirely to pain in the neck (ORs up to 2.0) and shoulders (ORs up to 3.4).Conclusions: Sickness absence for pain at specific anatomical sites is importantly associated with wider propensity to pain, the determinants of which extend beyond established risk factors such as somatising tendency and low mood. Better understanding of why some individuals are generally more prone to musculoskeletal pain might point to useful opportunities for prevention

Exile Vol. XLV No. 2

43rd Year Title Page 3 Epigraph by Ezra Pound 5 Table of Contents 7 Contributors Notes 74-75 Editorial Board 76 INTERVIEWS The Art of Hearing: Interview with Stanley Plumly by Alison Stine \u2700 23-27 ART Self-Portrait by Angela Bliss \u2799 8 For a Living by Angela Bliss \u2799 12 Untitled by Frazier Taylor \u2702 22 Untitled by Amy Deaner \u2799 29 Perfect Knee by David Tulkin \u2701 34 Untitled by Amy Deaner \u2799 43 Still Light by Angela Bliss \u2799 62 Hiding Nature by Amy Deaner \u2799 64 Self-Portrait A by Sarah Leyrer \u2701 73 POETRY Bolted Back by Michelle Grindstaff \u2702 9 Squall by Georgia Riepe \u2702 10 Loaves and Fishes by Maeghan Demmons \u2701 11 World Cafe by Katie Kroner \u2701 28 Gurney Surfer by Tom Hankinson \u2702 31 Japanese Beetles by Alison Stine \u2700 32-33 Shoveling by Bekah Taylor \u2700 40 Tobacco Country by K. Moore \u2701 41 Winton Place by Rachel Colina \u2702 42 Bottom of the Ninth by Michelle Grindstaff \u2702 61 Fall Burning by Alison Stine \u2700 63 rocking by Bekah Taylor \u2700 71 The Armor of the Beach by Georgia Riepe \u2702 72 PROSE In the Aisles of the Night by Tom Dussel \u2701 13-21 From Those Uninvolved by Justin Walker \u2799 30 Frame by Paul Durica \u2700 35-39 The Rose by Rachel Bolton \u2799 44-60 Stop at the Soldier by Hillary Campbell \u2700 65-70 All submissions are reviewed on an anonymous basis, and all editorial decisions are shared equally among the members of the Editorial Board. -76 Cover Art Untitled by Kris Lewis \u2799 / Back Cover Art Figure 25 by Todd Gys \u2799 -76 Printed by Printing Arts Press -7