Anomaluos RR Lyrae (V-I)_0 colors in Baade's Window

We compare (V-I)_0-(V-K)_0 color-color and (V-I)_0-log P period-color diagrams for Baade's Window and local RRab Lyrae stars. We find that for a fixed log P the Baade's Window RR Lyrae stars are ~0.17 magnitudes redder in (V-I)_0 than the local RR Lyrae stars. We also show that there is no such effect observed in (V-K)_0. We argue that an extinction misestimate towards Baade's Window is not a plausible explanation of the discrepancy. Unlike Baade's Window RR Lyrae stars, the local ones follow a black-body color-color relation and are well approximated by theoretical models. We test two parameters, metallicity and surface gravity, and find that their effects are too small to explain the (V-I)_0 discrepancy between the two groups of stars. We do not provide any explanation for the anomalous (V-I)_0 behavior of the Baade's Window RR Lyrae stars. We note that a similar effect for clump giant stars has been recently reported by Paczynski and we caution that RR Lyrae stars and clump giants, often used as standard candles, can be subject to the same type of systematics.Comment: 10 pages, 7 figures, submitted to Ap

Peripheral inflammation is associated with altered substantia nigra activity and psychomotor slowing in humans

BACKGROUND: Systemic infections commonly cause sickness symptoms including psychomotor retardation. Inflammatory cytokines released during the innate immune response are implicated in the communication of peripheral inflammatory signals to the brain. METHODS: We used functional magnetic resonance brain imaging (fMRI) to investigate neural effects of peripheral inflammation following typhoid vaccination in 16 healthy men, using a double-blind, randomized, crossover-controlled design. RESULTS: Vaccination had no global effect on neurovascular coupling but markedly perturbed neural reactivity within substantia nigra during low-level visual stimulation. During a cognitive task, individuals in whom typhoid vaccination engendered higher levels of circulating interleukin-6 had significantly slower reaction time responses. Prolonged reaction times and larger interleukin-6 responses were associated with evoked neural activity within substantia nigra. CONCLUSIONS: Our findings provide mechanistic insights into the interaction between inflammatio

Development and function of group 2 innate lymphoid cells

The innate lymphoid cell (ILC) family has recently expanded with the discovery of type-2 innate lymphoid cells (ILC2). These cells arise from lymphoid progenitors in the bone marrow and, under the control of the transcriptional regulators RORα and Gata3, they mature to give rise to IL-5, IL-9 and IL-13 producing ILC2. These cells are critical components of the innate immune response to parasitic worm infections and have also been implicated in the pathogenesis of asthma and allergy. Recent advances in our understanding of the molecular regulation of ILC2 development and function now present the opportunity to develop new genetic models to assess ILC2 immune function and to investigate possible therapeutic interventions

The Zero Point of Extinction Toward Baade's Window

We measure the zero point of the Stanek (1996) extinction map by comparing the observed (V-K) colors of 206 K giant stars with their intrinsic (V-K)_0 colors as derived from their H\beta indices. We find that the zero point of the Stanek map should be changed by \Delta A_V = -0.10 +/- 0.06 mag, obtaining as a bonus a three-fold reduction of the previous statistical error. The most direct way to test for systematic errors in this determination would be to conduct a parallel measurement based on the (V-K) colors of RR Lyraes (type ab).Comment: 10 pages, 1 figur

Deforming Soft Algebras for Gauge Theory

Symmetry algebras deriving from towers of soft theorems can be deformed by a short list of higher-dimension Wilsonian corrections to the effective action. We study the simplest of these deformations in gauge theory arising from a massless complex scalar coupled to $F^2$. The soft gauge symmetry '$s$-algebra', compactly realized as a higher-spin current algebra acting on the celestial sphere, is deformed and enlarged to an associative algebra containing soft scalar generators. This deformed soft algebra is found to be non-abelian even in abelian gauge theory. A two-parameter family of central extensions of the $s$-subalgebra are generated by shifting and decoupling the scalar generators. It is shown that these central extensions can also be generated by expanding around a certain non-trivial but Lorentz invariant shockwave type background for the scalar field.Comment: 13 pages, 1 figur

Ordering our world: the quest for traces of temporal organization in autobiographical memory

An experiment examined the idea, derived from the Self Memory System model (Conway & Pleydell-Pearce, 2000), that autobiographical events are sometimes tagged in memory with labels reflecting the life era in which an event occurred. The presence of such labels should affect the ease of judgments of the order in which life events occurred. Accordingly, 39 participants judged the order of two autobiographical events. Latency data consistently showed that between-era judgments were faster than within-era judgments, when the eras were defined in terms of either: (a) college versus high school, (b) academic quarter within year, or (c) academic year within school. The accuracy data similarly supported the presence of a between-era judgment effect for the college versus high school dichotomy

Sexually selected sentinels? Evidence of a role for intrasexual competition in sentinel behavior.

Although the evolutionary mechanisms that favor investment in cooperative behaviors have long been a focus of research, comparatively few studies have considered the role that sexual selection may play. For example, evolutionary explanations for sentinel behavior (where 1 individual assumes an elevated position and scans the surroundings while other group members forage nearby) have traditionally focused on the inclusive fitness benefits arising from its effects on predation risk, while its potential role in defense against intrasexual competitors remains largely unexplored. Here, we provide experimental evidence of a role for sentinel behavior in intrasexual competition, in a cooperatively breeding songbird, the white-browed sparrow weaver (Plocepasser mahali). First, dominant males sentinel substantially more than other group members (even when controlling for variation in age and body condition), consistent with a role for sentineling in intrasexual competition for mates and/or territory. Second, experimental playback of an unfamiliar male's solo song elicited a marked increase in sentineling by the dominant male, and the vocal response to the playback also positively predicted his sentinel effort following the simulated intrusion. A second experiment also suggests that sentineling may facilitate mounting rapid anti-intruder responses, as responses to intruder-playback occurred significantly earlier when the dominant male was sentineling rather than foraging at playback onset. Together, our findings provide rare support for the hypothesis that sentinel behavior plays a role in intrasexual competition, and so highlight the potential for sexually selected direct benefits to shape its expression in this and other social vertebrates

Concentration-Dependent Domain Evolution in Reaction–Diffusion Systems

Pattern formation has been extensively studied in the context of evolving (time-dependent) domains in recent years, with domain growth implicated in ameliorating problems of pattern robustness and selection, in addition to more realistic modelling in developmental biology. Most work to date has considered prescribed domains evolving as given functions of time, but not the scenario of concentration-dependent dynamics, which is also highly relevant in a developmental setting. Here, we study such concentration-dependent domain evolution for reaction–diffusion systems to elucidate fundamental aspects of these more complex models. We pose a general form of one-dimensional domain evolution and extend this to N-dimensional manifolds under mild constitutive assumptions in lieu of developing a full tissue-mechanical model. In the 1D case, we are able to extend linear stability analysis around homogeneous equilibria, though this is of limited utility in understanding complex pattern dynamics in fast growth regimes. We numerically demonstrate a variety of dynamical behaviours in 1D and 2D planar geometries, giving rise to several new phenomena, especially near regimes of critical bifurcation boundaries such as peak-splitting instabilities. For sufficiently fast growth and contraction, concentration-dependence can have an enormous impact on the nonlinear dynamics of the system both qualitatively and quantitatively. We highlight crucial differences between 1D evolution and higher-dimensional models, explaining obstructions for linear analysis and underscoring the importance of careful constitutive choices in defining domain evolution in higher dimensions. We raise important questions in the modelling and analysis of biological systems, in addition to numerous mathematical questions that appear tractable in the one-dimensional setting, but are vastly more difficult for higher-dimensional models