Modeling the Effects of Multiple Myeloma on Kidney Function

Multiple myeloma (MM), a plasma cell cancer, is associated with many health challenges, including damage to the kidney by tubulointerstitial fibrosis. We develop a mathematical model which captures the qualitative behavior of the cell and protein populations involved. Specifically, we model the interaction between cells in the proximal tubule of the kidney, free light chains, renal fibroblasts, and myeloma cells. We analyze the model for steady-state solutions to find a mathematically and biologically relevant stable steady-state solution. This foundational model provides a representation of dynamics between key populations in tubulointerstitial fibrosis that demonstrates how these populations interact to affect patient prognosis in patients with MM and renal impairment.Comment: Included version of model without tumor with steady-state analysis, corrected equations for free light chains and renal fibroblasts in model with tumor to reflect steady-state analysis, updated abstract, updated and added reference

ARXPS-studies ofcˆ-axis textured YBa2Cu3Ox-films

YBa2Cu3Ox sputter deposited cold on MgO grows in O2 annealing epitaxially to a transparent, superconducting film with Tc 80K. The unscraped surfaces of these films are smooth showing XPS lines changing with photoelectron take-off angle. This enhanced data base allows to separate the different chemical compounds (hydroxide, peroxide, carbonate, carboxyle, cuprate, graphite ...) and to obtain their spatial distribution. This yields the compounds, their amount and distribution making up the cinder growing with O2-anneal at internal and external surfaces. The cinder stoichiometry gives insights in the chemistry going on in O2 annealing. Below the cinder the signature ofcˆ-axis oriented YBa2Cu3Ox is identified, showing that a Ba-oxide layer forms the stable surface. This coats insulating CuO2 and Y-oxide layers yielding so an intrinsic dead layer

Civil Practice and Procedure

This article surveys recent significant developments in Virginia civil practice and procedure. Specifically, the article discusses opinions of the Supreme Court of Virginia from June 2010through June 2011 addressing civil procedure topics; significant amendments to the Rules of the Supreme Court of Virginia concerning procedural issues during the same period; and legislation enacted by the Virginia General Assembly during its 2011 session that relates to civil practice

Civil Practice and Procedure

This article surveys recent significant developments in Virginia civil practice and procedure. Specifically, the article discusses opinions of the Supreme Court of Virginia from June 2009 through April 2010 addressing civil procedure; significant amendments to the Rules of the Supreme Court of Virginia made during the same period; and legislation enacted by the Virginia GeneralAssembly during its 2010 session relating to civil practice

Design Knowledge for Deep-Learning-Enabled Image-Based Decision Support Systems

With the ever-increasing societal dependence on electricity, one of the critical tasks in power supply is maintaining the power line infrastructure. In the process of making informed, cost-effective, and timely decisions, maintenance engineers must rely on human-created, heterogeneous, structured, and also largely unstructured information. The maturing research on vision-based power line inspection driven by advancements in deep learning offers first possibilities to move towards more holistic, automated, and safe decision-making. However, (current) research focuses solely on the extraction of information rather than its implementation in decision-making processes. The paper addresses this shortcoming by designing, instantiating, and evaluating a holistic deep-learning-enabled image-based decision support system artifact for power line maintenance at a German distribution system operator in southern Germany. Following the design science research paradigm, two main components of the artifact are designed: A deep-learning-based model component responsible for automatic fault detection of power line parts as well as a user-oriented interface responsible for presenting the captured information in a way that enables more informed decisions. As a basis for both components, preliminary design requirements are derived from literature and the application field. Drawing on justificatory knowledge from deep learning as well as decision support systems, tentative design principles are derived. Based on these design principles, a prototype of the artifact is implemented that allows for rigorous evaluation of the design knowledge in multiple evaluation episodes, covering different angles. Through a technical experiment the technical novelty of the artifact’s capability to capture selected faults (regarding insulators and safety pins) in unmanned aerial vehicle (UAV)-captured image data (model component) is validated. Subsequent interviews, surveys, and workshops in a natural environment confirm the usefulness of the model as well as the user interface component. The evaluation provides evidence that (1) the image processing approach manages to address the gap of power line component inspection and (2) that the proposed holistic design knowledge for image-based decision support systems enables more informed decision-making. The paper therefore contributes to research and practice in three ways. First, the technical feasibility to detect certain maintenance-intensive parts of power lines with the help of unique UAV image data is shown. Second, the distribution system operators’ specific problem is solved by supporting decisions in maintenance with the proposed image-based decision support system. Third, precise design knowledge for image-based decision support systems is formulated that can inform future system designs of a similar nature

Quantum simulation of thermodynamics in an integrated quantum photonic processor

One of the core questions of quantum physics is how to reconcile the unitary evolution of quantum states, which is information-preserving and time-reversible, with evolution following the second law of thermodynamics, which, in general, is neither. The resolution to this paradox is to recognize that global unitary evolution of a multi-partite quantum state causes the state of local subsystems to evolve towards maximum-entropy states. In this work, we experimentally demonstrate this effect in linear quantum optics by simultaneously showing the convergence of local quantum states to a generalized Gibbs ensemble constituting a maximum-entropy state under precisely controlled conditions, while introducing an efficient certification method to demonstrate that the state retains global purity. Our quantum states are manipulated by a programmable integrated quantum photonic processor, which simulates arbitrary non-interacting Hamiltonians, demonstrating the universality of this phenomenon. Our results show the potential of photonic devices for quantum simulations involving non-Gaussian states

Noiseless Linear Amplification and Distillation of Entanglement

The idea of signal amplification is ubiquitous in the control of physical systems, and the ultimate performance limit of amplifiers is set by quantum physics. Increasing the amplitude of an unknown quantum optical field, or more generally any harmonic oscillator state, must introduce noise. This linear amplification noise prevents the perfect copying of the quantum state, enforces quantum limits on communications and metrology, and is the physical mechanism that prevents the increase of entanglement via local operations. It is known that non-deterministic versions of ideal cloning and local entanglement increase (distillation) are allowed, suggesting the possibility of non-deterministic noiseless linear amplification. Here we introduce, and experimentally demonstrate, such a noiseless linear amplifier for continuous-variables states of the optical field, and use it to demonstrate entanglement distillation of field-mode entanglement. This simple but powerful circuit can form the basis of practical devices for enhancing quantum technologies. The idea of noiseless amplification unifies approaches to cloning and distillation, and will find applications in quantum metrology and communications.Comment: Submitted 10 June 200

Use cases, best practice and reporting standards for metabolomics in regulatory toxicology

Metabolomics is a widely used technology in academic research, yet its application to regulatory science has been limited. The most commonly cited barrier to its translation is lack of performance and reporting standards. The MEtabolomics standaRds Initiative in Toxicology (MERIT) project brings together international experts from multiple sectors to address this need. Here, we identify the most relevant applications for metabolomics in regulatory toxicology and develop best practice guidelines, performance and reporting standards for acquiring and analysing untargeted metabolomics and targeted metabolite data. We recommend that these guidelines are evaluated and implemented for several regulatory use cases