Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

The Political Theory of Conservative Economists

Conrad Waligorski is professor emeritus of political science at the University of Arkansas. His publications include John Kenneth Galbraith: The Economist as Political Theorist and Anglo-American Liberalism: Readings in Normative Political Economy.This Kansas Open Books title is funded by a grant from the National Endowment for the Humanities and the Andrew W. Mellon Foundation Humanities Open Book Program.It’s difficult to overstate the impact of conservative economics on American life. The conservative thought of economists like Milton Friedman, James Buchanan, and Friedrick Hayek has provided the conceptual framework that undergirds nearly every aspect of current U.S. social-economic policy. Although a great deal has been written about the economic theories of these Nobel Prize-winning economists, this study is the first to examine the political theory that underlies conservative economics and its implications for public policy. Long associated with the “Chicago” and “public choice” schools of thought, Friedman, Buchanan, Hayek, and others have consistently repudiated Keynesian principles. They have steadfastly opposed social welfare policies and regulation of private enterprise, championing instead the free market as a mechanism for ordering society. In this book Conrad Waligorski analyzes the political content of the conservative economists’ arguments. In so doing, he illuminates the political, economic, and philosophical ideas behind and justification for the laissez-faire policy—the reduced regulation, intervention, and welfare favored by conservative governments in the United States, Canada, and Britain

The Political Theory of Conservative Economists

It’s difficult to overstate the impact of conservative economics on American life. The conservative thought of economists like Milton Friedman, James Buchanan, and Friedrick Hayek has provided the conceptual framework that undergirds nearly every aspect of current U.S. social-economic policy. Although a great deal has been written about the economic theories of these Nobel Prize-winning economists, this study is the first to examine the political theory that underlies conservative economics and its implications for public policy. Long associated with the “Chicago” and “public choice” schools of thought, Friedman, Buchanan, Hayek, and others have consistently repudiated Keynesian principles. They have steadfastly opposed social welfare policies and regulation of private enterprise, championing instead the free market as a mechanism for ordering society. In this book Conrad Waligorski analyzes the political content of the conservative economists’ arguments. In so doing, he illuminates the political, economic, and philosophical ideas behind and justification for the laissez-faire policy—the reduced regulation, intervention, and welfare favored by conservative governments in the United States, Canada, and Britain. Description Conrad Waligorski is professor emeritus of political science at the University of Arkansas. His publications include John Kenneth Galbraith: The Economist as Political Theorist and Anglo-American Liberalism: Readings in Normative Political Economy. This Kansas Open Books title is funded by a grant from the National Endowment for the Humanities and the Andrew W. Mellon Foundation Humanities Open Book Program.https://digitalcommons.pittstate.edu/kansas_open_books/1063/thumbnail.jp

The Political Theory of Conservative Economists

It’s difficult to overstate the impact of conservative economics on American life. The conservative thought of economists like Milton Friedman, James Buchanan, and Friedrick Hayek has provided the conceptual framework that undergirds nearly every aspect of current U.S. socialeconomic policy. Although a great deal has been written about the economic theories of these Nobel Prizewinning economists, this study is the first to examine the political theory that underlies conservative economics and its implications for public policy.Long associated with the “Chicago” and “public choice” schools of thought, Friedman, Buchanan, Hayek, and others have consistently repudiated Keynesian principles. They have steadfastly opposed social welfare policies and regulation of private enterprise, championing instead the free market as a mechanism for ordering society.In this book Conrad Waligorski analyzes the political content of the conservative economists’ arguments. In so doing, he illuminates the political, economic, and philosophical ideas behind and justification for the laissezfaire policy—the reduced regulation, intervention, and welfare favored by conservative governments in the United States, Canada, and Britain