9 research outputs found
The impact of environmental noise generated from ports: outcome of MESP project
Ports are characterized by several complex operations. Accordingly, the analysis of noise results is complicated due to the presence in the same area of diverse sound from ships, trade and also from industrial and shipyards activities aswell as auxiliary services producing negative effects on natural ecosystem and the urban population. The ENPI CBC MED project Managing the Environmental Sustainability of Ports for a durable development (MESP) addressed the pollution reduction from port activities through the implementation of a multidisciplinary approach in air, noise andwater sectors, encompassing technological, regulatory and administrative solutions to ensure natural and urban sustainability and high level of life quality in surrounding territories. To prevent a heterogeneous development, the \u201cstatus quo\u201d of ports in Northern and Southern Shores of the Mediterranean Sea was analyzed and a guideline on methodologies, good practices and measurement assessment, adaptable and transferable in different port contexts was elaborated. To assess the procedures, validation tests have been carried out to different real cases. In noise sector pilot projects in the ports of Patras, Greece, and Tripoli, Lebanon, have been implemented. Due to the dissimilar scenarios, in terms of orography, facilities and activities, different noise mitigation actions and interventions were consequently accomplished
The impact of environmental noise generated from ports: outcome of MESP project
Ports are characterized by several complex operations.
Accordingly, the analysis of noise results is complicated
due to the presence in the same area of diverse
sound from ships, trade and also from industrial and shipyards
activities aswell as auxiliary services producing negative
effects on natural ecosystem and the urban population.
The ENPI CBC MED project Managing the Environmental
Sustainability of Ports for a durable development
(MESP) addressed the pollution reduction from port activities
through the implementation of a multidisciplinary approach
in air, noise andwater sectors, encompassing technological,
regulatory and administrative solutions to ensure
natural and urban sustainability and high level of life
quality in surrounding territories. To prevent a heterogeneous
development, the âstatus quoâ of ports in Northern
and Southern Shores of the Mediterranean Sea was analyzed
and a guideline on methodologies, good practices
and measurement assessment, adaptable and transferable
in different port contexts was elaborated. To assess the
procedures, validation tests have been carried out to different
real cases. In noise sector pilot projects in the ports
of Patras, Greece, and Tripoli, Lebanon, have been implemented.
Due to the dissimilar scenarios, in terms of orography,
facilities and activities, different noise mitigation actions
and interventions were consequently accomplished
Bi-phased regulation of the post-transcriptional inflammatory response by Tristetraprolin levels
Managing European Cross Border Cooperation Projects on Sustainability: A Focus on MESP Project
International cooperation is a must to achieve the goal of sustainable development, since only through cross border actionsâ complex issues like environmental degradation can be faced. Supranational initiatives and shared objectives are the only path for getting a durable and effective green strategy, which transcends boundaries or governments and fosters a common effort for sustainability through networking. The European Neighborhood and Partnership Instrument (ENPI) aims at reinforcing cooperation between the European Union (EU) and partner countriesâ regions placed along the shores of the Mediterranean Sea. To this extent, MESP (Managing the Environmental Sustainability of Ports for a durable development) can be considered as a typical cross border cooperation project, willing to create a sustainable environmental management of port in northern and southern shores of the Mediterranean basin. This has been achieved through the development of specific guidelines towards environmental sustainability and the collection of common tools, methodologies, good practices and innovations focused on pollution reduction that can be replicated in Mediterranean ports and further. This was possible through the creation of a strong cooperation network and long-lasting collaborations among partners and stakeholders such as harbour cities, port authorities, universities, research centres and scientific skills
Managing European Cross Border Cooperation Projects on Sustainability: A Focus on MESP Project
Systematic analysis of AU-rich element expression in cancer reveals common functional clusters regulated by key RNA-binding proteins
A novel mechanism for variable phenotypic expressivity in Mendelian diseases uncovered by an AU-rich element (ARE)-creating mutation
Abstract Background Variable expressivity is a well-known phenomenon in which patients with mutations in one gene display varying degrees of clinical severity, potentially displaying only subsets of the clinical manifestations associated with the multisystem disorder linked to the gene. This remains an incompletely understood phenomenon with proposed mechanisms ranging from allele-specific to stochastic. Results We report three consanguineous families in which an isolated ocular phenotype is linked to a novel 3ⲠUTR mutation in SLC4A4, a gene known to be mutated in a syndromic form of intellectual disability with renal and ocular involvement. Although SLC4A4 is normally devoid of AU-rich elements (AREs), a 3ⲠUTR motif that mediates post-transcriptional control of a subset of genes, the mutation we describe creates a functional ARE. We observe a marked reduction in the transcript level of SLC4A4 in patient cells. Experimental confirmation of the ARE-creating mutation is shown using a post-transcriptional reporter system that reveals consistent reduction in the mRNA-half life and reporter activity. Moreover, the neo-ARE binds and responds to the zinc finger protein ZFP36/TTP, an ARE-mRNA decay-promoting protein. Conclusions This novel mutational mechanism for a Mendelian disease expands the potential mechanisms that underlie variable phenotypic expressivity in humans to also include 3ⲠUTR mutations with tissue-specific pathology