Visual bias of diagram in logical reasoning

We analyze the information discrepancy between diagram- matic representations and logical reasoning, which we call visual biases in diagrammatic reasoning. Diagrammatic repre- sentations contain semantic information, which is based on the topological configurations of objects, and visual information, such as geometric location. In principle, visual information is unnecessary to the validity of logical reasoning. However, people are so sensitive to visual information such as size and shape in diagrams that they occasionally do not ignore irrele- vant information. This phenomenon leads to mistakes in logical reasoning. We addressed this issue in the present study. In Experiment 1, we assessed whether and how a visual bias of external diagrams affects reasoning performance. We asked participants to directly manipulate size-fixed (Euler) diagrams while solving syllogistic tasks. In Experiment 2, we tested whether size-scalable diagrams were able to reduce a visual bias of diagrams in logical reasoning

Strategy analysis of non-consequence inference with Euler diagrams

How can Euler diagrams support non-consequence inferences? Although an inference to non-consequence, in which people are asked to judge whether no valid conclusion can be drawn from the given premises (e.g., All B are A; No C are B), is one of the two sides of logical inference, it has received remarkably little attention in research on human diagrammatic reasoning; how diagrams are really manipulated for such inferences remains unclear. We hypothesized that people naturally make these inferences by enumerating possible diagrams, based on the logical notion of self-consistency, in which every (simple) Euler diagram is true (satisfiable) in a set-theoretical interpretation. The work is divided into three parts, each exploring a particular condition or scenario. In condition 1, we asked participants to directly manipulate diagrams with size-fixed circles as they solved syllogistic tasks, with the result that more reasoners used the enumeration strategy. In condition 2, another type of size-fixed diagram was used. The diagram layout change interfered with accurate task performances and with the use of the enumeration strategy; however, the enumeration strategy was still dominant for those who could correctly perform the tasks. In condition 3, we used size-scalable diagrams (with the default size as in condition 2), which reduced the interfering effect of diagram layout and enhanced participants' selection of the enumeration strategy. These results provide evidence that non-consequence inferences can be achieved by diagram enumeration, exploiting the self-consistency of Euler diagrams. An alternate strategy based on counter-example construction with Euler diagrams, as well as effects of diagram layout in inferential processes, are also discussed

Myofibroblasts acquire retinoic acid–producing ability during fibroblast-to-myofibroblast transition following kidney injury

腎障害における線維化の正の側面の発見 --線維化が腎臓を修復する--. 京都大学プレスリリース. 2019-01-18.Tubular injury and interstitial fibrosis are the hallmarks of chronic kidney disease. While recent studies have verified that proximal tubular injury triggers interstitial fibrosis, the impact of fibrosis on tubular injury and regeneration remains poorly understood. We generated a novel mouse model expressing diphtheria toxin receptor on renal fibroblasts to allow for the selective disruption of renal fibroblast function. Administration of diphtheria toxin induced upregulation of the tubular injury marker Ngal and caused tubular proliferation in healthy kidneys, whereas administration of diphtheria toxin attenuated tubular regeneration in fibrotic kidneys. Microarray analysis revealed down-regulation of the retinol biosynthesis pathway in diphtheria toxin-treated kidneys. Healthy proximal tubules expressed retinaldehyde dehydrogenase 2 (RALDH2), a rate-limiting enzyme in retinoic acid biosynthesis. After injury, proximal tubules lost RALDH2 expression, whereas renal fibroblasts acquired strong expression of RALDH2 during the transition to myofibroblasts in several models of kidney injury. The retinoic acid receptor (RAR) RARγ was expressed in proximal tubules both with and without injury, and αB-crystallin, the product of an RAR target gene, was strongly expressed in proximal tubules after injury. Furthermore, BMS493, an inverse agonist of RARs, significantly attenuated tubular proliferation in vitro. In human biopsy tissue from patients with IgA nephropathy, detection of RALDH2 in the interstitium correlated with older age and lower kidney function. These results suggest a role of retinoic acid signaling and cross-talk between fibroblasts and tubular epithelial cells during tubular injury and regeneration, and may suggest a beneficial effect of fibrosis in the early response to injury