Management of Wound Myiasis in the Hospice and Palliative Medicine Setting

Medical Schoolhttp://deepblue.lib.umich.edu/bitstream/2027.42/170657/1/GavishaWaidyaratne_1.docxhttp://deepblue.lib.umich.edu/bitstream/2027.42/170657/2/GavishaWaidyaratne_2.pptxhttp://deepblue.lib.umich.edu/bitstream/2027.42/170657/3/GavishaWaidyaratne_3.pd

Ultra-Rare Mutation in Long-Range Enhancer Predisposes to Thyroid Carcinoma with High Penetrance

Peer reviewe

Procoagulant Microparticle Interactions Due to P-sel-Ig in Hemophilia A Patients

Congenital hemophilia is a hereditary, X-linked blood-clotting disease that involves insufficient clotting factors VIII and IX. There are two types of hemophilia, Hemophilia A and Hemophilia B. Hemophilia A is the most common form of hemophilia affecting individuals. Current treatment options include recombinant or concentrated plasma procoagulant. However, immunity to these treatment options as well as high treatment cost is common. This research models a treatment option involving P-selectin. P-selectin is a known precursor to tissue clotting factors already present in the body, and therefore can minimize the issue of immunity to treatment. The purpose of this research is to optimize the delivery of a P-selectin precursor in order to minimize clotting time and reduce immunity to drug therapy for hemophilia patients. In order to simulate this treatment, the drug P-sel-Ig was assumed to have been injected and reacted within the vein to produce an initial steadystate microparticle concentration. In COMSOL, as mass transport through a cylindrical vessel with fluid flow. This model measures the time it takes to accumulate enough fibrin to fully clot the wound. The model also optimizes microparticle concentration to minimize the time taken to clot the wound. The model can be adjusted for varying wound size, location, and time of formation. This model was validated in optimizing microparticle concentration for promoting the clotting of wounds. The literature value for wound clotting time is approximately 4.5 minutes. In order to achieve a complete wound clot, the clotting time from the model was approximately 35 minutes, which is within an order of magnitude from the literature value. This research defines clotting time as the number of minutes necessary to reach a 90% threshold fibrin density packing ratio. The optimal initial microparticle concentration was 2.66×10 5 mol/m 3 . In addition, the model showed that as wound size increases, the time necessary to close the wound also increases. The computation model demonstrated a range of initial microparticle concentrations necessary to provide adequate fibrin clot formation in response to the wound. The results of this model can potentially be used in optimizing the design of a regularly administered drug therapy for hemophilia patients to facilitate efficient clotting. This drug therapy would be cheaper treatment option because of its longer halflife. It would also prevent the formation of antibodies, which reduces the effectiveness of current treatment options

Design, implementation, and reflections on a two-week virtual visual arts and medicine course for third- and fourth-year medical students

Abstract Background Medical humanities courses that incorporate the visual arts traditionally require in-person instruction and visits to museums. The COVID-19 pandemic afforded medical educators a unique opportunity to implement and evaluate virtual visual arts programming. Methods A two-week, 7-module visual arts and medicine elective course for third and fourth-year medical students was conducted virtually in the Spring of 2021. The course included traditional didactic components as well as a range of hands-on creative art activities including painting, graphic medicine, photovoice, and Kintsugi (Japanese craft). Digital tools including Canvas, Google Jamboard, and Zoom facilitated student engagement. Student feedback was collected through anonymous post-course surveys. Results We successfully conducted a virtual visual arts and medicine elective which integrated hands-on creative art activities. Most students “strongly agreed” that remote instruction was sufficient to meet course objectives. However, all students also “agreed” that in-person instruction may promote more in-depth engagement with the visual arts. The hands-on creative art activities were appreciated by all students. Conclusion Visual arts-based medical humanities courses can be delivered virtually and can include hands-on creative art activities such as painting. Future visual arts and medicine courses may benefit from incorporating a range of pedagogical methodologies, digital tools, control groups, and pre−/post-course assessments.http://deepblue.lib.umich.edu/bitstream/2027.42/173629/1/12909_2022_Article_3374.pd

Bringing the classroom to the streets: A multimodal approach

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/170866/1/medu14662.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/170866/2/medu14662_am.pd