An intelligent knowledge processing system on hydrodynamics and water quality modeling

Series: Lecture notes in computer scienceAuthor name used in this publication: K. W. ChauAuthor name used in this publication: O. WaiAuthor name used in this publication: Y. S. Li2001-2002 > Academic research: refereed > Publication in refereed journalAccepted ManuscriptPublishe

Transport and adsorption of antibiotics by marine sediments in a dynamic environment

Author name used in this publication: Weihai H. XuAuthor name used in this publication: Onyx W. H. WaiAuthor name used in this publication: Shichun C. ZouAuthor name used in this publication: Xiangdong D. Li2008-2009 > Academic research: refereed > Publication in refereed journalAccepted ManuscriptPublishe

Trace metal distribution in sediments of the Pearl River Estuary and the surrounding coastal area, South China

Author name used in this publication: Carman C. M. IpAuthor name used in this publication: Onyx W. H. Wai2006-2007 > Academic research: refereed > Publication in refereed journalAccepted ManuscriptPublishe

Over one hundred years of trace metal fluxes in the sediments of the Pearl River Estuary, South China

Author name used in this publication: C. C. M. IpAuthor name used in this publication: X. D. LiAuthor name used in this publication: G. ZhangAuthor name used in this publication: O. W. H. WaiAuthor name used in this publication: Y. S. Li2003-2004 > Academic research: refereed > Publication in refereed journalAccepted ManuscriptPublishe

Distribution of organochlorine pesticides in a sediment profile of the Pearl River estuary

Author name used in this publication: X. D. LiAuthor name used in this publication: B. X. MaiAuthor name used in this publication: G. ZhangAuthor name used in this publication: G. Y. ShengAuthor name used in this publication: J. M. FuAuthor name used in this publication: O. W. H. WaiAuthor name used in this publication: Y. S. Li2001-2002 > Academic research: refereed > Publication in refereed journalAccepted ManuscriptPublishe

Study on the dynamics of algal bloom and its influence factors in Tolo Harbour, Hong Kong

Author name used in this publication: Y. S. LiAuthor name used in this publication: Onyx W. H. WaiAuthor name used in this publication: B. King2004-2005 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

A Perspective on Cell Therapy and Cancer Vaccine in Biliary Tract Cancers (BTCs).

Biliary tract cancer (BTC) is a rare, but aggressive, disease that comprises of gallbladder carcinoma, intrahepatic cholangiocarcinoma and extrahepatic cholangiocarcinoma, with heterogeneous molecular profiles. Advanced disease has limited therapeutic options beyond first-line platinum-based chemotherapy. Immunotherapy has emerged as a viable option for many cancers with a similar unmet need. Therefore, we reviewed current understanding of the tumor immune microenvironment and recent advances in cellular immunotherapy and therapeutic cancer vaccines against BTC. We illustrated the efficacy of dendritic cell vaccination in one patient with advanced, chemorefractory, melanoma-associated antigen (MAGE)-positive gallbladder carcinoma, who was given multiple injections of an allogenic MAGE antigen-positive melanoma cell lysate (MCL)-based autologous dendritic cell vaccine combined with sequential anti-angiogenic therapy. This resulted in good radiological and tumor marker response and an overall survival of 3 years from diagnosis. We postulate the potential synergism of adding anti-angiogenic therapy, such as bevacizumab, to immunotherapy in BTC, as a rational scientific principle to positively modulate the tumor microenvironment to augment antitumor immunity

Spontaneously Reported Hepatic Adverse Drug Events in Korea: Multicenter Study

Hepatic adverse drug reactions (ADRs) to certain drugs may differ within each country, reflecting different patterns of prescription, socioeconomic status, and culture. The purpose of this study was to assess the suspected cause of hepatic ADRs using the spontaneously reported pharmacovigilance data from Korea. A total of 9,360 spontaneously reported adverse drug events (ADEs) from nine Pharmacovigilance Centers were analyzed. Risk of hepatic ADEs was assessed by calculating the reporting odds ratio (ROR). Of the 9,360 cases, 567 hepatic ADEs were reported. The most frequently prescribed drug classes inducing hepatic ADEs were anti-tuberculotics, cephalosporins, valproic acids, penicillins, quinolones, non-steroidal anti-inflammatory drugs (NSAIDs), anti-viral agents, and statins. ROR values were especially high in anti-tuberculosis drugs, systemic antifungal drugs for systemic use, anti-epileptics, propylthiouracil, and herbal medicines. Underlying diseases such as tuberculosis (6.9% vs 0.9%), pneumonia (4.9% vs 1.7%), intracranial injury including skull fracture (4.5% vs 0.9%), HIV (3.4% vs 0.4%), subarachnoid hemorrhage (2.8% vs 0.5%), and osteoporosis (2.4% vs 1.4%) were significantly more common in hepatic ADE group. In conclusion, anti-infective drugs, anti-epileptics, NSAIDs and statins are the most common suspects of the spontaneously reported hepatic ADEs, in Korea. Careful monitoring for such reactions is needed for the prescription of these drugs