1,596 research outputs found
IVF treatment of moderate male factor infertility: a comparison of mini-Percoll, partial zona dissection and sub-zonal sperm insertion techniques
In this study we examined various techniques of in-vitro fertilization (IVF) for treating couples in whom the male had subnormal semen parameters. We compared two sperm preparation methods (mini-Percoll and conventional swim-up) for efficiency of recovery after preparation and for fertilization rates after IVF, and compared the suitability of partial zona dissection (PZD) and sub-zonal sperm insertion (SUZI) to patients with different types of male factor infertility. The mini-Percoll technique allowed the recovery of significantly more motile spermatozoa from the same semen sample compared to the swim-up method. More oocytes were fertilized after spermatozoa were prepared by the mini-Percoll technique. An increased number of spermatozoa recovered from an ejaculate led to an improvement in the quality of spermatozoa in the insemination droplet. Subsequently, when using the PZD technique, the fertilization rate increased when there was a higher number of spermatozoa in the patient's ejaculate. When comparing the two micromanipulation techniques, SUZI provided patients with oligoasthenzoo-spermia (i.e. < 10 × 106 spermatozoa/ml and 40% motility) with a higher chance of obtaining 2-pronculeate egg
Effects and Detectability of Quasi-Single Field Inflation in the Large-Scale Structure and Cosmic Microwave Background
Quasi-single field inflation predicts a peculiar momentum dependence in the
squeezed limit of the primordial bispectrum which smoothly interpolates between
the local and equilateral models. This dependence is directly related to the
mass of the isocurvatons in the theory which is determined by the
supersymmetry. Therefore, in the event of detection of a non-zero primordial
bispectrum, additional constraints on the parameter controlling the
momentum-dependence in the squeezed limit becomes an important question. We
explore the effects of these non-Gaussian initial conditions on large-scale
structure and the cosmic microwave background, with particular attention to the
galaxy power spectrum at large scales and scale-dependence corrections to
galaxy bias. We determine the simultaneous constraints on the two parameters
describing the QSF bispectrum that we can expect from upcoming large-scale
structure and cosmic microwave background observations. We find that for
relatively large values of the non-Gaussian amplitude parameters, but still
well within current uncertainties, galaxy power spectrum measurements will be
able to distinguish the QSF scenario from the predictions of the local model. A
CMB likelihood analysis, as well as Fisher matrix analysis, shows that there is
also a range of parameter values for which Planck data may be able distinguish
between QSF models and the related local and equilateral shapes. Given the
different observational weightings of the CMB and LSS results, degeneracies can
be significantly reduced in a joint analysis.Comment: 27 pages, 14 figure
Constraining Scale-Dependent Non-Gaussianity with Future Large-Scale Structure and the CMB
We forecast combined future constraints from the cosmic microwave background
and large-scale structure on the models of primordial non-Gaussianity. We study
the generalized local model of non-Gaussianity, where the parameter f_NL is
promoted to a function of scale, and present the principal component analysis
applicable to an arbitrary form of f_NL(k). We emphasize the complementarity
between the CMB and LSS by using Planck, DES and BigBOSS surveys as examples,
forecast constraints on the power-law f_NL(k) model, and introduce the figure
of merit for measurements of scale-dependent non-Gaussianity.Comment: 28 pages, 8 figures, 2 tables; v2: references update
Active Galactic Nuclei at the Crossroads of Astrophysics
Over the last five decades, AGN studies have produced a number of spectacular
examples of synergies and multifaceted approaches in astrophysics. The field of
AGN research now spans the entire spectral range and covers more than twelve
orders of magnitude in the spatial and temporal domains. The next generation of
astrophysical facilities will open up new possibilities for AGN studies,
especially in the areas of high-resolution and high-fidelity imaging and
spectroscopy of nuclear regions in the X-ray, optical, and radio bands. These
studies will address in detail a number of critical issues in AGN research such
as processes in the immediate vicinity of supermassive black holes, physical
conditions of broad-line and narrow-line regions, formation and evolution of
accretion disks and relativistic outflows, and the connection between nuclear
activity and galaxy evolution.Comment: 16 pages, 5 figures; review contribution; "Exploring the Cosmic
Frontier: Astrophysical Instruments for the 21st Century", ESO Astrophysical
Symposia Serie
Evidence for charge localization in the ferromagnetic phase of La_(1-x)Ca_(x)MnO_3 from High real-space-resolution x-ray diffraction
High real-space-resolution atomic pair distribution functions of
La_(1-x)Ca_(x)MnO_3 (x=0.12, 0.25 and 0.33) have been measured using
high-energy x-ray powder diffraction to study the size and shape of the MnO_6
octahedron as a function of temperature and doping. In the paramagnetic
insulating phase we find evidence for three distinct bond-lengths (~ 1.88, 1.95
and 2.15A) which we ascribe to Mn^{4+}-O, Mn^{3+}-O short and Mn^{3+}-O long
bonds respectively. In the ferromagnetic metallic (FM) phase, for x=0.33 and
T=20K, we find a single Mn-O bond-length; however, as the metal-insulator
transition is approached either by increasing T or decreasing x, intensity
progressively appears around r=2.15 and in the region 1.8 - 1.9A suggesting the
appearance of Mn^{3+}-O long bonds and short Mn^{4+}-O bonds. This is strong
evidence that charge localized and delocalized phases coexist close to the
metal-insulator transition in the FM phase.Comment: 8 pages, 8 postscript figures, submitted to Phys. Rev.
Charge Transport Through Open, Driven Two-Level Systems with Dissipation
We derive a Floquet-like formalism to calculate the stationary average
current through an AC driven double quantum dot in presence of dissipation. The
method allows us to take into account arbitrary coupling strengths both of a
time-dependent field and a bosonic environment. We numerical evaluate a
truncation scheme and compare with analytical, perturbative results such as the
Tien-Gordon formula.Comment: 14 pages, 6 figures. To appear in Phys. Rev.
Cost-effectiveness of closed incision negative pressure wound therapy in preventing surgical site infection among obese women giving birth by caesarean section: An economic evaluation (DRESSING trial)
First published: 18 May 2023.
OnlinePublBackground: There is growing evidence regarding the potential of closed incision negative pressure wound therapy (ci-NPWT) to prevent surgical site infections (SSIs) in healing wounds by primary closure following a caesarean section (CS). Aim: To assess the cost-effectiveness of ci-NPWT compared to standard dressings for prevention of SSI in obese women giving birth by CS. Materials and Methods: Cost-effectiveness and cost-utility analyses from a health service perspective were undertaken alongside a multicentre pragmatic randomised controlled trial, which recruited women with a pre-pregnancy body mass index ≥30 kg/m2 giving birth by elective/semi-urgent CS who received ci-NPWT (n = 1017) or standard dressings (n = 1018). Resource use and health-related quality of life (SF-12v2) collected during admission and for four weeks post-discharge were used to derive costs and quality-adjusted life years (QALYs). Results: ci-NPWT was associated with AUD170 to 12 849 (95%CI −133 378) per SSI avoided. There was no detectable difference in QALYs between groups; however, there are high levels of uncertainty around both cost and QALY estimates. There is a 20% likelihood that ci-NPWT would be considered cost-effective at a willingness-to- pay threshold of $50 000 per QALY. Per protocol and complete case analyses gave similar results, suggesting that findings are robust to protocol deviators and adjustments for missing data. Conclusions: ci-NPWT for the prevention of SSI in obese women undergoing CS is unlikely to be cost-effective in terms of health service resources and is currently unjustified for routine use for this purpose.Jennifer A. Whitty, Adam P. Wagner, Evelyn Kang, David Ellwood, Wendy Chaboyer, Sailesh Kumar, Vicki L. Clifton, Lukman Thalib and Brigid M. Gillespi
Spin fluctuations in nearly magnetic metals from ab-initio dynamical spin susceptibility calculations:application to Pd and Cr95V5
We describe our theoretical formalism and computational scheme for making
ab-initio calculations of the dynamic paramagnetic spin susceptibilities of
metals and alloys at finite temperatures. Its basis is Time-Dependent Density
Functional Theory within an electronic multiple scattering, imaginary time
Green function formalism. Results receive a natural interpretation in terms of
overdamped oscillator systems making them suitable for incorporation into spin
fluctuation theories. For illustration we apply our method to the nearly
ferromagnetic metal Pd and the nearly antiferromagnetic chromium alloy Cr95V5.
We compare and contrast the spin dynamics of these two metals and in each case
identify those fluctuations with relaxation times much longer than typical
electronic `hopping times'Comment: 21 pages, 9 figures. To appear in Physical Review B (July 2000
Production of eta and 3pi mesons in the pd->3HeX reaction at 1360 and 1450 MeV
The cross sections of the pd -> 3He eta, pd -> 3He pi0 pi0 pi0 and pd -> 3He
pi+ pi- pi0 reactions have been measured at beam kinetic energies T_p= 1360 MeV
and T_p= 1450 MeV using the CELSIUS/WASA detector setup. At both energies, the
differential cross section dsigma/dOmega of the eta meson in the pd -> 3He eta
reaction shows a strong forward-backward asymmetry in the CMS. The ratio
between the pd -> 3He pi+ pi- pi0 and the pd -> 3He pi0 pi0 pi0 cross sections
has been analysed in terms of isospin amplitudes. The reconstructed invariant
mass distributions of the pi-pi, 3He-pi and 3He-2pi systems provide hints on
the role of nucleon resonances in the 3pi production process.Comment: Shorter version accepted to EPJA 10 pages 14 figure
Effective interaction between helical bio-molecules
The effective interaction between two parallel strands of helical
bio-molecules, such as deoxyribose nucleic acids (DNA), is calculated using
computer simulations of the "primitive" model of electrolytes. In particular we
study a simple model for B-DNA incorporating explicitly its charge pattern as a
double-helix structure. The effective force and the effective torque exerted
onto the molecules depend on the central distance and on the relative
orientation. The contributions of nonlinear screening by monovalent counterions
to these forces and torques are analyzed and calculated for different salt
concentrations. As a result, we find that the sign of the force depends
sensitively on the relative orientation. For intermolecular distances smaller
than it can be both attractive and repulsive. Furthermore we report a
nonmonotonic behaviour of the effective force for increasing salt
concentration. Both features cannot be described within linear screening
theories. For large distances, on the other hand, the results agree with linear
screening theories provided the charge of the bio-molecules is suitably
renormalized.Comment: 18 pages, 18 figures included in text, 100 bibliog
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