1,921 research outputs found
Feasibility and Design Studies: Camplain Valley Sanitary Landfill
Guidebook for field trips in Vermont: 64th annual meeting October 13, 14, 15, 1972 Burlington, Vermont: Trip EG-
Field theoretic calculation of the surface tension for a model electrolyte system
We carry out the calculation of the surface tension for a model electrolyte
to first order in a cumulant expansion about a free field theory equivalent to
the Debye-H\"uckel approximation. In contrast with previous calculations, the
surface tension is calculated directly without recourse to integrating
thermodynamic relations. The system considered is a monovalent electrolyte with
a region at the interface, of width h, from which the ionic species are
excluded. In the case where the external dielectric constant epsilon_0 is
smaller than the electrolyte solution's dielectric constant epsilon we show
that the calculation at this order can be fully regularized. In the case where
h is taken to be zero the Onsager-Samaras limiting law for the excess surface
tension of dilute electrolyte solutions is recovered, with corrections coming
from a non-zero value of epsilon_0/epsilon.Comment: LaTeX, 14 pages, 3 figures, 1 tabl
The Efficiency of Globular Cluster Formation
(Abridged): The total populations of globular cluster systems (GCSs) are
discussed in terms of their connection to the efficiency of globular cluster
formation---the mass fraction of star-forming gas that was able to form bound
stellar clusters rather than isolated stars or unbound associations---in galaxy
halos. Observed variations in GCS specific frequencies (S_N=N_gc/L_gal), both
as a function of galactocentric radius in individual systems and globally
between entire galaxies, are reviewed in this light. It is argued that trends
in S_N do not reflect any real variation in the underlying efficiency of
cluster formation; rather, they result from ignoring the hot gas in many large
ellipticals. This claim is checked and confirmed in each of M87, M49, and NGC
1399, for which existing data are combined to show that the volume density
profile of globular clusters, rho_cl, is directly proportional to the sum of
(rho_gas+rho_stars) at large radii. The constant of proportionality is the same
in each case: epsilon=0.0026 +/- 0.0005 in the mean. This is identified with
the globular cluster formation efficiency. The implication that epsilon might
have had a universal value is supported by data on the GCSs of 97 early-type
galaxies, on the GCS of the Milky Way, and on the ongoing formation of open
clusters. These results have specific implications for some issues in GCS and
galaxy formation, and they should serve as a strong constraint on more general
theories of star and cluster formation.Comment: 36 pages with 11 figures; accepted for publication in The
Astronomical Journa
A randomized phase 2 network trial of tivantinib plus cetuximab versus cetuximab in patients with recurrent/metastatic head and neck squamous cell carcinoma
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154935/1/cncr32762.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/154935/2/cncr32762_am.pd
Breast cancer detection: radiologists’ performance using mammography with and without automated whole-breast ultrasound
ObjectiveRadiologist reader performance for breast cancer detection using mammography plus automated whole-breast ultrasound (AWBU) was compared with mammography alone.MethodsScreenings for non-palpable breast malignancies in women with radiographically dense breasts with contemporaneous mammograms and AWBU were reviewed by 12 radiologists blinded to the diagnoses; half the studies were abnormal. Readers first reviewed the 102 mammograms. The American College of Radiology (ACR) Breast Imaging Reporting and Data System (BIRADS) and Digital Mammographic Imaging Screening Trial (DMIST) likelihood ratings were recorded with location information for identified abnormalities. Readers then reviewed the mammograms and AWBU with knowledge of previous mammogram-only evaluation. We compared reader performance across screening techniques using absolute callback, areas under the curve (AUC), and figure of merit (FOM).ResultsTrue positivity of cancer detection increased 63%, with only a 4% decrease in true negativity. Reader-averaged AUC was higher for mammography plus AWBU compared with mammography alone by BIRADS (0.808 versus 0.701) and likelihood scores (0.810 versus 0.703). Similarly, FOM was higher for mammography plus AWBU compared with mammography alone by BIRADS (0.786 versus 0.613) and likelihood scores (0.791 versus 0.614).ConclusionAdding AWBU to mammography improved callback rates, accuracy of breast cancer detection, and confidence in callbacks for dense-breasted women
Loss of Dnmt3b function upregulates the tumor modifier Ment and accelerates mouse lymphomagenesis
DNA methyltransferase 3B (Dnmt3b) belongs to a family of enzymes responsible for methylation of cytosine residues in mammals. DNA methylation contributes to the epigenetic control of gene transcription and is deregulated in virtually all human tumors. To better understand the generation of cancer-specific methylation patterns, we genetically inactivated Dnmt3b in a mouse model of MYC-induced lymphomagenesis. Ablation of Dnmt3b function using a conditional knockout in T cells accelerated lymphomagenesis by increasing cellular proliferation, which suggests that Dnmt3b functions as a tumor suppressor. Global methylation profiling revealed numerous gene promoters as potential targets of Dnmt3b activity, the majority of which were demethylated in Dnmt3b–/– lymphomas, but not in Dnmt3b–/– pretumor thymocytes, implicating Dnmt3b in maintenance of cytosine methylation in cancer. Functional analysis identified the gene Gm128 (which we termed herein methylated in normal thymocytes [Ment]) as a target of Dnmt3b activity. We found that Ment was gradually demethylated and overexpressed during tumor progression in Dnmt3b–/– lymphomas. Similarly, MENT was overexpressed in 67% of human lymphomas, and its transcription inversely correlated with methylation and levels of DNMT3B. Importantly, knockdown of Ment inhibited growth of mouse and human cells, whereas overexpression of Ment provided Dnmt3b+/+ cells with a proliferative advantage. Our findings identify Ment as an enhancer of lymphomagenesis that contributes to the tumor suppressor function of Dnmt3b and suggest it could be a potential target for anticancer therapies
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