Efficient Strategies for Graph Pattern Mining Algorithms on GPUs

Graph Pattern Mining (GPM) is an important, rapidly evolving, and computation demanding area. GPM computation relies on subgraph enumeration, which consists in extracting subgraphs that match a given property from an input graph. Graphics Processing Units (GPUs) have been an effective platform to accelerate applications in many areas. However, the irregularity of subgraph enumeration makes it challenging for efficient execution on GPU due to typical uncoalesced memory access, divergence, and load imbalance. Unfortunately, these aspects have not been fully addressed in previous work. Thus, this work proposes novel strategies to design and implement subgraph enumeration efficiently on GPU. We support a depth-first search style search (DFS-wide) that maximizes memory performance while providing enough parallelism to be exploited by the GPU, along with a warp-centric design that minimizes execution divergence and improves utilization of the computing capabilities. We also propose a low-cost load balancing layer to avoid idleness and redistribute work among thread warps in a GPU. Our strategies have been deployed in a system named DuMato, which provides a simple programming interface to allow efficient implementation of GPM algorithms. Our evaluation has shown that DuMato is often an order of magnitude faster than state-of-the-art GPM systems and can mine larger subgraphs (up to 12 vertices).Comment: Accepted for publication on IEEE 34th International Symposium on Computer Architecture and High Performance Computing (SBAC-PAD'22

Induction and characterization of anti-tumor endothelium immunity elicited by ValloVax therapeutic cancer vaccine.

ValloVax is a placental endothelium derived vaccine which induces tissue-nonspecific antitumor immunity by blocking tumor angiogesis. To elucidate mechanisms of action, we showed that production of ValloVax, which involves treating placental endothelial cells with IFN-gamma, results in upregulation of HLA and costimulatory molecules. It was shown that in mixed lymphocyte reaction, ValloVax induces Type I cytokines and allo-proliferative responses. Plasma from ValloVax immunized mice was capable of killing in vitro tumor-like endothelium but not control endothelium. Using defined antigens associated with tumor endothelial cells, specific molecular entities were identified as being targeted by ValloVax induced antibodies. Binding of predominantly IgG antibodies to ValloVax cells was confirmed by flow cytometry. Further suggesting direct killing of tumor endothelial cells was expression of TUNEL positive cells, as well as, reduction in tumor oxygenation. Supporting a role for antibody mediated responses, cell depletion experiments suggested a predominant role of B cells in maintaining an intact anti-tumor endothelial response. Adoptive transfer experiments suggested that infusion of CD3+ T cells from immunized mice was sufficient to transfer tumor protection. Generation of memory T cells selective to tumor endothelial specific markers was observed. Functional confirmation of memory responses was observed in tumor rechallenge experiments. Furthermore, we observed that both PD-1 or CTLA-4 blockade augmented antitumor effects of ValloVax. These data suggest a T cell induced B cell mediated anti-tumor endothelial response and set the framework clinical trials through elucidation of mechanism of action

The Ursinus Weekly, December 13, 1965

Dean explains Student Activities Committee • Clamer girls bring to campus the Sound of Christmas • Mary Griffiths reigns over Prom • Festivities fill U.C. holiday week • Tradition highlights 28th Messiah performance • H-ford prof to speak on Vietnam • Second student concert attended by UC students • Summer jobs abound in D.C. • Greeks hold kids\u27 Xmas parties • Editorial: Congratulations to the Agency; APO decorates campus; Nocturnal serenade • How does a Mr. become a Dr. ? Reporter traces progress of Professor to demonstrate long, arduous route • Is CMP integrated? No! Now wait! Just maybe • Page editor analyzes dining hall situation; Blames both sides for affair, but sees real hope ahead • Grapplers pin Delaware Valley team • Intramural corner • B-ballers set mark: Rout drew 109-78 as Troster scores his 1,000th point • Football banquet • Letter winners • Greek gleanings • Pledging fills campus with wacky sights as frats and sororities test new members: Girls model PJs, learn birthdays, decorate rooms; Men wear shirts, drink raw eggs, visit Syracusehttps://digitalcommons.ursinus.edu/weekly/1213/thumbnail.jp

The Ursinus Weekly, May 21, 1909

Brotherhood of St. Paul fletcherizes • Buffalo Bill in Philadelphia • Malcolm Shackelford entertains audience • Glee club • Lecture • Baseball • Ursinus Union • Tennis tournament • Society notes • Alumni notes • Personals • Field house fund • Literary Supplement: A day in May; The power of sentiment; A generation of vipers; Literary criticism on Tolstoy; The power of ideas; Money and hypocrisyhttps://digitalcommons.ursinus.edu/weekly/2873/thumbnail.jp

Magnetic and transport properties of Mo substituted La0.67Ba0.33Mn1-xMoxO3 perovskite system

The effect of doping Mo for Mn on the magnetic and transport properties of the colossal magnetoresistance material, La0.67Ba0.33MnO3, has been studied. Compounds of the series La0.67Ba0.33Mn1-xMoxO3 (x=0.0 to 0.1) have been prepared and found to crystallize in the orthorhombic structure (space group Pbnm). Energy Dispersive X-ray Analysis (EDAX) measurements confirm the stoichiometry of all the samples. Magnetotransport and magnetization measurements reveal that the metal-insulator transition temperature (Tp) decreases from 330K for x=0 to 255K for x=0.1. The change in Tp on Mo substitution is relatively much smaller than the corresponding change observed on substitution by other transition elements, such as Ti, Fe, Co, Ni, etc. Further, the ferromagnetic transition temperature (TC) is nearly unchanged by Mo substitution. This is in striking contrast to the large decrease in TC observed with substitution of above-mentioned 3d elements. These unusual magnetic and transport properties of La0.67Ba0.33Mn1-xMoxO3 may be either due to the formation of magnetic pair between Mn and Mo or due to strong Mo(4d)-O(2p) overlap, which in turn, may affect the Mn-Mn interaction via the oxygen atomsComment: 25 pages, 5 figure

Structure and function of the ROR2 cysteine-rich domain in vertebrate noncanonical WNT5A signaling

The receptor tyrosine kinase ROR2 mediates noncanonical WNT5A signaling to orchestrate tissue morphogenetic processes, and dysfunction of the pathway causes Robinow syndrome, brachydactyly B, and metastatic diseases. The domain(s) and mechanisms required for ROR2 function, however, remain unclear. We solved the crystal structure of the extracellular cysteine-rich (CRD) and Kringle (Kr) domains of ROR2 and found that, unlike other CRDs, the ROR2 CRD lacks the signature hydrophobic pocket that binds lipids/lipid-modified proteins, such as WNTs, suggesting a novel mechanism of ligand reception. Functionally, we showed that the ROR2 CRD, but not other domains, is required and minimally sufficient to promote WNT5A signaling, and Robinow mutations in the CRD and the adjacent Kr impair ROR2 secretion and function. Moreover, using function-activating and -perturbing antibodies against the Frizzled (FZ) family of WNT receptors, we demonstrate the involvement of FZ in WNT5A-ROR signaling. Thus, ROR2 acts via its CRD to potentiate the function of a receptor super-complex that includes FZ to transduce WNT5A signals

Molecular mechanism of BMP signal control by Twisted gastrulation

Twisted gastrulation (TWSG1) is an evolutionarily conserved secreted glycoprotein which controls signaling by Bone Morphogenetic Proteins (BMPs). TWSG1 binds BMPs and their antagonist Chordin to control BMP signaling during embryonic development, kidney regeneration and cancer. We report crystal structures of TWSG1 alone and in complex with a BMP ligand, Growth Differentiation Factor 5. TWSG1 is composed of two distinct, disulfide-rich domains. The TWSG1 N-terminal domain occupies the BMP type 1 receptor binding site on BMPs, whereas the C-terminal domain binds to a Chordin family member. We show that TWSG1 inhibits BMP function in cellular signaling assays and mouse colon organoids. This inhibitory function is abolished in a TWSG1 mutant that cannot bind BMPs. The same mutation in the Drosophila TWSG1 ortholog Tsg fails to mediate BMP gradient formation required for dorsal-ventral axis patterning of the early embryo. Our studies reveal the evolutionarily conserved mechanism of BMP signaling inhibition by TWSG1

Report of the CCQM-K130 : Nitrogen mass fraction measurements in glycine

Mass fraction of nitrogen is very important pointer because the results of these measurements are often used for determination of protein mass fraction that is an important indicator of the quality of the vast majority of food products and raw materials, in particular dry milk powder. Proteins-enzymes catalyze chemical reactions, protein along with fats and carbohydrates is one of the indicators characterizing the energy value of food, so its definition is mandatory for all food products. The aim of this key comparison CCQM-K130 and pilot study P166 is to support National Measurement Institutes (NMIs) and Designated Institutes (DIs) to demonstrate the validity of the procedures the employed for determination of nitrogen mass fraction in glycine. The study material for this key comparison and pilot study has been selected to be representative as one of the aminoacid – the simplest part of the protein. Glycine is an amino acid, single acid that does not have any isomers (melting point –290 °C; specific heat of evaporation − 528,6 J/kg; specific melting heat − 981,1 J/kg; pKa − 2,34, molar mass - 75,07 g/mol, density - 1,607 g/cm3). Ural Scientific Research Institute for Metrology (UNIIM) acted as the coordinating laboratory of this comparison and pilot study. Eight NMIs participated in this key comparison and two NMIs participated in Pilot study. The results of Pilot study are excluded from the Report B.Fil: Medvedevskikh, Maria. Ural Scientific Research Institute for Metrology (UNIIM); RusiaFil: Jury, Bessonov. Ural Scientific Research Institute for Metrology (UNIIM); RusiaFil: Krasheninina, Maria. Ural Scientific Research Institute for Metrology (UNIIM); RusiaFil: Acco Garcia, Steve Ali. (INACAL); PerúFil: Haraldsson, Conny. SP Technical Research Institute of Sweden; SueciaFil: Rodriguez, M. Alejandra. Instituto Nacional de Tecnología Industrial (INTI); ArgentinaFil: Rodriguez, Gabriela. Instituto Nacional de Tecnología Industrial (INTI); ArgentinaFil: Salvo, Karino. Laboratorio Tecnológico del Uruguay (LATU); UruguayFil: Gavrilkin, Vladimir. (UkrCSM); UcraniaFil: Kulik, Sergey. (UkrCSM); UcraniaFil: Samuel, Laly. (MSL); Nueva ZelandaFil: do Rego, Eliane C. P. Instituto Nacional de Metrologia, Qualidade e Tecnologia (INMetro); BrasilFil: Wollinger, Wagner. Instituto Nacional de Metrologia, Qualidade e Tecnologia (INMetro); BrasilFil: Monteiro, Tânia M. Instituto Nacional de Metrologia, Qualidade e Tecnologia (INMetro); BrasilFil: de Carvalho, Lucas J. Instituto Nacional de Metrologia, Qualidade e Tecnologia (INMetro); Brasi

The effect of a supplementary ('Gist-based') information leaflet on colorectal cancer knowledge and screening intention: a randomized controlled trial.

Guided by Fuzzy Trace Theory, this study examined the impact of a 'Gist-based' leaflet on colorectal cancer screening knowledge and intentions; and tested the interaction with participants' numerical ability. Adults aged 45-59 years from four UK general practices were randomly assigned to receive standard information ('The Facts', n = 2,216) versus standard information plus 'The Gist' leaflet (Gist + Facts, n = 2,236). Questionnaires were returned by 964/4,452 individuals (22 %). 82 % of respondents reported having read the information, but those with poor numeracy were less likely (74 vs. 88 %, p < .001). The 'Gist + Facts' group were more likely to reach the criterion for adequate knowledge (95 vs. 91 %; p < .01), but this was not moderated by numeracy. Most respondents (98 %) intended to participate in screening, with no group differences and no interaction with numeracy. The improved levels of knowledge and self-reported reading suggest 'The Gist' leaflet may increase engagement with colorectal cancer screening, but ceiling effects reduced the likelihood that screening intentions would be affected

Acute cardiometabolic effects of brief active breaks in sitting for patients with rheumatoid arthritis

Exercise is a treatment in rheumatoid arthritis, but participation in moderate-to-vigorous exercise is challenging for some patients. Light-intensity breaks in sitting could be a promising alternative. We compared the acute effects of active breaks in sitting with those of moderate-to-vigorous exercise on cardiometabolic risk markers in patients with rheumatoid arthritis. In a crossover fashion, 15 women with rheumatoid arthritis underwent three 8-h experimental conditions: prolonged sitting (SIT), 30-min bout of moderate-to-vigorous exercise followed by prolonged sitting (EX), and 3-min bouts of light-intensity walking every 30 min of sitting (BR). Postprandial glucose, insulin, c-peptide, triglycerides, cytokines, lipid classes/subclasses (lipidomics), and blood pressure responses were assessed. Muscle biopsies were collected following each session to assess targeted proteins/genes. Glucose [−28% in area under the curve (AUC), P = 0.036], insulin (−28% in AUC, P = 0.016), and c-peptide (−27% in AUC, P = 0.006) postprandial responses were attenuated in BR versus SIT, whereas only c-peptide was lower in EX versus SIT (−20% in AUC, P = 0.002). IL-1β decreased during BR, but increased during EX and SIT (P = 0.027 and P = 0.085, respectively). IL-1ra was increased during EX versus BR (P = 0.002). TNF-α concentrations decreased during BR versus EX (P = 0.022). EX, but not BR, reduced systolic blood pressure (P = 0.013). Lipidomic analysis showed that 7 of 36 lipid classes/subclasses were significantly different between conditions, with greater changes being observed in EX. No differences were observed for protein/gene expression. Brief active breaks in sitting can offset markers of cardiometabolic disturbance, which may be particularly useful for patients who may find it difficult to adhere to exercise. NEW & NOTEWORTHY Exercise is a treatment in rheumatoid arthritis but is challenging for some patients. Light-intensity breaks in sitting could be a promising alternative. Our findings show beneficial, but differential, cardiometabolic effects of active breaks in sitting and exercise in patients with rheumatoid arthritis. Breaks in sitting mainly improved glycemic and inflammatory markers, whereas exercise improved lipidomic and hypotensive responses. Breaks in sitting show promise in offsetting aspects of cardiometabolic disturbance associated with prolonged sitting in rheumatoid arthritis