3,652 research outputs found
Two-lane traffic rules for cellular automata: A systematic approach
Microscopic modeling of multi-lane traffic is usually done by applying
heuristic lane changing rules, and often with unsatisfying results. Recently, a
cellular automaton model for two-lane traffic was able to overcome some of
these problems and to produce a correct density inversion at densities somewhat
below the maximum flow density. In this paper, we summarize different
approaches to lane changing and their results, and propose a general scheme,
according to which realistic lane changing rules can be developed. We test this
scheme by applying it to several different lane changing rules, which, in spite
of their differences, generate similar and realistic results. We thus conclude
that, for producing realistic results, the logical structure of the lane
changing rules, as proposed here, is at least as important as the microscopic
details of the rules
Oxygen pathway modeling estimates high Reactive oxygen species production above the highest permanent human habitation.
The production of reactive oxygen species (ROS) from the inner mitochondrial membrane is one of many fundamental processes governing the balance between health and disease. It is well known that ROS are necessary signaling molecules in gene expression, yet when expressed at high levels, ROS may cause oxidative stress and cell damage. Both hypoxia and hyperoxia may alter ROS production by changing mitochondrial Po2 (). Because depends on the balance between O2 transport and utilization, we formulated an integrative mathematical model of O2 transport and utilization in skeletal muscle to predict conditions to cause abnormally high ROS generation. Simulations using data from healthy subjects during maximal exercise at sea level reveal little mitochondrial ROS production. However, altitude triggers high mitochondrial ROS production in muscle regions with high metabolic capacity but limited O2 delivery. This altitude roughly coincides with the highest location of permanent human habitation. Above 25,000 ft., more than 90% of exercising muscle is predicted to produce abnormally high levels of ROS, corresponding to the "death zone" in mountaineering
Long-lived states in synchronized traffic flow. Empirical prompt and dynamical trap model
The present paper proposes a novel interpretation of the widely scattered
states (called synchronized traffic) stimulated by Kerner's hypotheses about
the existence of a multitude of metastable states in the fundamental diagram.
Using single vehicle data collected at the German highway A1, temporal velocity
patterns have been analyzed to show a collection of certain fragments with
approximately constant velocities and sharp jumps between them. The particular
velocity values in these fragments vary in a wide range. In contrast, the flow
rate is more or less constant because its fluctuations are mainly due to the
discreteness of traffic flow.
Subsequently, we develop a model for synchronized traffic that can explain
these characteristics. Following previous work (I.A.Lubashevsky, R.Mahnke,
Phys. Rev. E v. 62, p. 6082, 2000) the vehicle flow is specified by car
density, mean velocity, and additional order parameters and that are
due to the many-particle effects of the vehicle interaction. The parameter
describes the multilane correlations in the vehicle motion. Together with the
car density it determines directly the mean velocity. The parameter , in
contrast, controls the evolution of only. The model assumes that
fluctuates randomly around the value corresponding to the car configuration
optimal for lane changing. When it deviates from this value the lane change is
depressed for all cars forming a local cluster. Since exactly the overtaking
manoeuvres of these cars cause the order parameter to vary, the evolution
of the car arrangement becomes frozen for a certain time. In other words, the
evolution equations form certain dynamical traps responsible for the long-time
correlations in the synchronized mode.Comment: 16 pages, 10 figures, RevTeX
Towards a Macroscopic Modelling of the Complexity in Traffic Flow
We present a macroscopic traffic flow model that extends existing fluid-like
models by an additional term containing the second derivative of the safe
velocity. Two qualitatively different shapes of the safe velocity are explored:
a conventional Fermi-type function and a function exhibiting a plateau at
intermediate densities. The suggested model shows an extremely rich dynamical
behaviour and shows many features found in real-world traffic data.Comment: submitted to Phys. Rev.
Dopamine transporter genotype is associated with a lateralized resistance to distraction during attention selection
Although lateral asymmetries in orienting behavior are evident across species and have been linked to interhemispheric asymmetries in dopamine signaling, the relative contribution of attentional versus motoric processes remains unclear. Here we took a cognitive genetic approach to adjudicate between roles for dopamine in attentional versus response selection. A sample of nonclinical adult humans (N = 518) performed three cognitive tasks (spatial attentional competition, spatial cueing, and flanker tasks) that varied in the degree to which they required participants to resolve attentional or response competition. All participants were genotyped for two putatively functional tandem repeat polymorphisms of the dopamine transporter gene (DAT1; SLC6A3), which are argued to influence the level of available synaptic dopamine and confer risk to disorders of inattention. DAT1 genotype modulated the task-specific effects of the various task-irrelevant stimuli across both the spatial competition and spatial cueing but not flanker tasks. Specifically, compared with individuals carrying one or two copies of the 10-repeat DAT1 allele, individuals without this allele demonstrated an immunity to distraction, such that response times were unaffected by increases in the number of distractor stimuli, particularly when these were presented predominantly in the left hemifield. All three genotype groups exhibited uniform costs of resolving leftward response selection in a standard flanker task. None of these significant effects could be explained by speed–accuracy trade-offs, suggesting that participants without the 10-repeat allele of the DAT1 tandem repeat polymorphism possess an enhanced attentional ability to suppress task-irrelevant stimuli in the left hemifield
Emergency department-based peer support for opioid use disorder: Emergent functions and forms
Emergency department (ED)-based peer support programs aimed at linking persons with opioid use disorder (OUD) to medication for addiction treatment and other recovery services are a promising approach to addressing the opioid crisis. This brief report draws on experiences from three states' experience with such programs funded by the SAMHSA Opioid State Targeted Repose (STR) grants. Core functions of such programs include: Integration of peer supports in EDs; Alerting peers of eligible patients and making the patient aware of peer services; and connecting patients with recovery services. Qualitative data were analyzed using a general inductive approach conducted in 3 steps in order to identify forms utilized to fulfill these functions. Peer integration differed in terms of peer's physical location and who hired and supervised peers. Peers often depend on ED staff to alert them to potential patients while people other than the peers often first introduce potential patients to programming. Programs generally schedule initial appointments for recovery services for patients, but some programs provide a range of other services aimed at supporting participation in recovery services. Future effectiveness evaluations of ED-based peer support programs for OUD should consistently report on forms used to fulfill core functions
Spinodal decomposition of off-critical quenches with a viscous phase using dissipative particle dynamics in two and three spatial dimensions
We investigate the domain growth and phase separation of
hydrodynamically-correct binary immiscible fluids of differing viscosity as a
function of minority phase concentration in both two and three spatial
dimensions using dissipative particle dynamics. We also examine the behavior of
equal-viscosity fluids and compare our results to similar lattice-gas
simulations in two dimensions.Comment: 34 pages (11 figures); accepted for publication in Phys. Rev.
An ongoing case-control study to evaluate the NHS Bowel Cancer Screening Programme
© 2014 Massat et al.; licensee BioMed Central. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated
Facial recognition from DNA using face-to-DNA classifiers
Facial recognition from DNA refers to the identification or verification of unidentified biological material against facial images with known identity. One approach to establish the identity of unidentified biological material is to predict the face from DNA, and subsequently to match against facial images. However, DNA phenotyping of the human face remains challenging. Here, another proof of concept to biometric authentication is established by using multiple face-to-DNA classifiers, each classifying given faces by a DNA-encoded aspect (sex, genomic background, individual genetic l
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