Project report – transferable skills in higher education

This study was initiated by the need, frequently expressed by employers, for the education system to produce potential employees with better transferable skills. The paper reports a field trial at a UK university (following a four-year pilot of NVQ Level 4 Key Skills with another course). The project operated within a new foundation (Level 0) programme, aiming to simplify the paperwork employed in the pilot and incorporate skills assessment within modules, thereby obviating the need for a portfolio of evidence. The project was successful in only one or two modules, those where staff were committed to the aims

Experimental demonstration of a graph state quantum error-correction code

Scalable quantum computing and communication requires the protection of quantum information from the detrimental effects of decoherence and noise. Previous work tackling this problem has relied on the original circuit model for quantum computing. However, recently a family of entangled resources known as graph states has emerged as a versatile alternative for protecting quantum information. Depending on the graph's structure, errors can be detected and corrected in an efficient way using measurement-based techniques. In this article we report an experimental demonstration of error correction using a graph state code. We have used an all-optical setup to encode quantum information into photons representing a four-qubit graph state. We are able to reliably detect errors and correct against qubit loss. The graph we have realized is setup independent, thus it could be employed in other physical settings. Our results show that graph state codes are a promising approach for achieving scalable quantum information processing

Regulating the employment dynamics of domestic supply chains

This paper sheds light on the role that the regulation of primarily domestic, rather than global, supply chains could play in protecting and enhancing standards of workplace health and safety, as well as employment standards more generally. The analysis presented confirms the potential relevance of such regulation in these regards. However, it also reinforces existing evidence pointing to the fact that only very rarely will market-related considerations on their own prompt purchasers to seek to directly influence the employment practices of their suppliers. The paper ends therefore by highlighting a number of key issues relating to the design of regulatory initiatives aimed at protecting and enhancing employment conditions within supply chains

Protecting workers through supply chains: lessons from two construction case studies

Two case studies of the successful use of supply chains to support the effective management of health and safety on constructions sites are analysed to identify the factors supporting this success. The analysis reveals that a combination of external regulatory pressures and an industry structure facilitative of the establishment and implementation of ‘good practice’ played a crucial role in the outcomes achieved. It is concluded therefore that while the findings lend weight to policy initiatives to utilise the power dynamics in supply chains to protect working conditions, they also suggest that surrounding institutional and industrial contexts exert a potentially crucial influence over their effectiveness. Consequently, it is further argued that such initiatives need to be responsively shaped to them

Recent advances in understanding mammalian prion structure

Prions are lethal pathogens, which cause fatal neurodegenerative diseases in mammals. They are unique infectious agents and are composed of self-propagating multi-chain assemblies of misfolded host-encoded prion protein (PrP). Understanding prion structure is fundamental to understanding prion disease pathogenesis however to date, the high-resolution structure of authentic ex vivo infectious prions remains unknown. Advances in determining prion structure have been severely impeded by the difficulty in recovering relatively homogeneous prion particles from infected brain and definitively associating infectivity with the PrP assembly state. Recently, however, images of highly infectious ex vivo PrP rods that produce prion-strain specific disease phenotypes in mice have been obtained using cryo-electron microscopy and atomic force microscopy. These images have provided the most detailed description of ex vivo mammalian prions reported to date and have established that prions isolated from multiple strains have a common hierarchical structure. Misfolded PrP is assembled into 20 nm wide rods containing two fibers, each with double helical repeating substructure, separated by a characteristic central gap 8-10 nm in width. Irregularly structured material with adhesive properties distinct to that of the fibers is present within the central gap of the rod. Prions are clearly distinguishable from non-infectious recombinant PrP fibrils generated in vitro and from all other propagating protein structures so far described in other neurodegenerative diseases. The basic architecture of mammalian prions appears to be exceptional and fundamental to their lethal pathogenicity

The search for pre-clovis in the ice-free corridor: archaeological geophysics at Wally’s Beach

Wally’s Beach is an important archaeological/paleontological locality in southern Alberta where pre-Clovis dates have been reported from butchered faunal remains, but associated cultural materials are poorly known. Significant challenges exist for research at the site, including poor access, limited stratigraphy, and the extreme size of the site (>2km2). Ground-penetrating radar and drone imagery were conducted to identify higher-potential areas, which discovered a possible paleochannel. This discovery aids future research efforts at Wally’s Beach to better understand the earliest human occupation of the ice-free corridor

Broadband infrared meanderline reflective quarter-wave plate

We present a novel reflective quarter-wave plate comprised of subwavelength meanderline elements. The device is operational over the long-wave infrared (LWIR) spectrum, with significant spectral and angular bandwidths. Power reflection is approximately 70% over the majority of the LWIR. Efficient conversion from a 45 linear polarization state into circular polarization is demonstrated from finite-element electromagnetic simulations and from broadband polarimetric measurements

The relationship between oxidised LDL, endothelial progenitor cells and coronary endothelial function in patients with CHD

Objective The balance between coronary endothelial dysfunction and repair is influenced by many protective and deleterious factors circulating in the blood. We studied the relationship between oxidised low-density lipoprotein (oxLDL), circulating endothelial progenitor cells (EPCs) and coronary endothelial function in patients with stable coronary heart disease (CHD). Methods 33 patients with stable CHD were studied. Plasma oxLDL was measured using ELISA, coronary endothelial function was assessed using intracoronary acetylcholine infusion and EPCs were quantified using flow cytometry for CD34+/KDR+ cells. Results Plasma oxLDL correlated positively with the number of EPCs in the blood (r=0.46, p=0.02). There was a positive correlation between the number of circulating EPCs and coronary endothelial function (r=0.42, p=0.04). There was no significant correlation between oxLDL and coronary endothelial function. Conclusions Plasma levels of oxLDL are associated with increased circulating EPCs in the blood of patients with CHD, which may reflect a host-repair response to endothelial injury. Patients with stable CHD had a high prevalence of coronary endothelial dysfunction, which was associated with lower numbers of circulating EPCs, suggesting a mechanistic link between endothelial dysfunction and the pathogenesis of atherosclerosis