High incidence of Angina pectoris in patients treated with 5-fluorouracil - A planned surveillance study with 102 patients

Objective: Angina pectoris, arrhythmic sudden death and myocardial infarction, all these cardiac events have occasionally been reported during 5-fluorouracil (5-FU) chemotherapy. Underlying mechanisms leading to these events are unknown; damage to the myocytes or vasospasms have been discussed. Methods: 102 consecutive and unselected patients were monitored with 12-lead ECG, echocardiography and radionuclide ventriculography prior to the first cycle of 5-FU chemotherapy and 3 months from baseline. Results: 19% of the patients developed reversible symptoms of angina pectoris during treatment which lasted up to 12 h after cessation of the infusion. Most of the 19 patients showed corresponding ECG changes. 6 out of the 19 patients with severe angina pectoris had subsequent coronary angiography. In none of these patients the coronary angiography showed coronary artery disease, but it showed low ventricular function (ejection fraction <50%) in 2 patients. The ejection fraction did not increase overtime. Arrhythmias were screened for with Holter monitoring during 5-FU chemotherapy. The frequency of bradycardia and ventricular extrasystoles increased significantly (p < 0.05) during treatment compared to arrhythmias in Holter monitoring 3 months later. Furthermore the Qtc time in the ECG 3 months later was significantly prolonged (p < 0.05) compared to baseline values. Conclusions:The incidence of angina pectoris in patients during 5-FU treatment seems higher than previously suspected. As myocardial ischemia can be fatal, attentiveness to these symptoms and immediate treatment are crucial. Copyright (C) 2003 S. Karger AG, Basel

Discovering the Higgs with Low Mass Muon Pairs

Many models of electroweak symmetry breaking have an additional light pseudoscalar. If the Higgs boson can decay to a new pseudoscalar, LEP searches for the Higgs can be significantly altered and the Higgs can be as light as 86 GeV. Discovering the Higgs boson in these models is challenging when the pseudoscalar is lighter than 10 GeV because it decays dominantly into tau leptons. In this paper, we discuss discovering the Higgs in a subdominant decay mode where one of the pseudoscalars decays to a pair of muons. This search allows for potential discovery of a cascade-decaying Higgs boson with the complete Tevatron data set or early data at the LHC.Comment: 10 pages, 7 figure

Reheating Metastable O'Raifeartaigh Models

In theories with multiple vacua, reheating to a temperature greater than the height of a barrier can stimulate transitions from a desirable metastable vacuum to a lower energy state. We discuss the constraints this places on various theories and demonstrate that in a class of supersymmetric models this transition does not occur even for arbitrarily high reheating temperature.Comment: 21 pages, 1 figure. Typos corrected and some references adde

It's On: Early Interpretations of ATLAS Results in Jets and Missing Energy Searches

The first search for supersymmetry from ATLAS with 70/nb of integrated luminosity extends the Tevatron' s reach for colored particles that decay into jets plus missing transverse energy. For gluinos that decay directly or through a one step cascade into the LSP and two jets, the mass range m_g < 205 GeV is disfavored by the ATLAS searches, regardless of the mass of the LSP. In some cases the coverage extends up to m_g ~ 295 GeV, already surpassing the Tevatron's reach for compressed supersymmetry spectra.Comment: 5 pages, 3 figures, 1 table; references and figure added; Physics Letters B (2011

Rationale for a Stronger Disposition of Chardonnay Wines for Stuck and Sluggish Fermentation

The aim of this study was to identify and evaluate factors that contribute to fermentation problems inChardonnay, since this variety is reported to have frequent problems. Analytical methods included gaschromatography mass spectrometry, as well as atomic absorption spectroscopy and FT-MIR spectroscopy.Chardonnay, Pinot blanc, Pinot noir and Pinot noir précoce were screened to relate observations to specificvarietal properties. The results show a significant distinction in the amino acid profile of Chardonnay,which can be correlated with sluggish fermentation. A comparison between the fatty acid profile ofChardonnay and Pinot blanc reveals that Chardonnay contains more toxic compounds, which inhibityeast metabolism. Mineral supply and potential metal toxicity were also analysed. The concentrationsof iron, copper, magnesium, zinc and manganese show significant variations among the grape varieties.In conclusion, the possible causes for stuck fermentation in Chardonnay could be more related more tovariety than to oenological decisions

SUSY Simplified Models at 14, 33, and 100 TeV Proton Colliders

Results are presented for a variety of SUSY Simplified Models at the 14 TeV LHC as well as a 33 and 100 TeV proton collider. Our focus is on models whose signals are driven by colored production. We present projections of the upper limit and discovery reach in the gluino-neutralino (for both light and heavy flavor decays), squark-neutralino, and gluino-squark Simplified Model planes. Depending on the model a jets + MET, mono-jet, or same-sign di-lepton search is applied. The impact of pileup is explored. This study utilizes the Snowmass backgrounds and combined detector. Assuming 3000 fb^{-1} of integrated luminosity, a gluino that decays to light flavor quarks can be discovered below 2.3 TeV at the 14 TeV LHC and below 11 TeV at a 100 TeV machine.Comment: 81 pages, 55 figures; v2 journal versio

A hybrid model for chaotic front dynamics: From semiconductors to water tanks

We present a general method for studying front propagation in nonlinear systems with a global constraint in the language of hybrid tank models. The method is illustrated in the case of semiconductor superlattices, where the dynamics of the electron accumulation and depletion fronts shows complex spatio-temporal patterns, including chaos. We show that this behavior may be elegantly explained by a tank model, for which analytical results on the emergence of chaos are available. In particular, for the case of three tanks the bifurcation scenario is characterized by a modified version of the one-dimensional iterated tent-map.Comment: 4 pages, 4 figure

Coherent Transport through an interacting double quantum dot: Beyond sequential tunneling

Various causes for negative differential conductance in transport through an interacting double quantum dot are investigated. Particular focus is given to the interplay between the renormalization of the energy levels due to the coupling to the leads and the decoherence of the states. The calculations are performed within a basis of many-particle eigenstates and we consider the dynamics given by the von Neumann-equation taking into account also processes beyond sequential tunneling. A systematic comparison between the levels of approximation and also with different formalisms is performed. It is found that the current is qualitatively well described by sequential processes as long as the temperature is larger than the level broadening induced by the contacts.Comment: 11 pages, 5 figures included in tex

Center of mass and relative motion in time dependent density functional theory

It is shown that the exchange-correlation part of the action functional $A_{xc}[\rho (\vec r,t)]$ in time-dependent density functional theory , where $\rho (\vec r,t)$ is the time-dependent density, is invariant under the transformation to an accelerated frame of reference $\rho (\vec r,t) \to \rho ' (\vec r,t) = \rho (\vec r + \vec x (t),t)$, where $\vec x (t)$ is an arbitrary function of time. This invariance implies that the exchange-correlation potential in the Kohn-Sham equation transforms in the following manner: $V_{xc}[\rho '; \vec r, t] = V_{xc}[\rho; \vec r + \vec x (t),t]$. Some of the approximate formulas that have been proposed for $V_{xc}$ satisfy this exact transformation property, others do not. Those which transform in the correct manner automatically satisfy the ``harmonic potential theorem", i.e. the separation of the center of mass motion for a system of interacting particles in the presence of a harmonic external potential. A general method to generate functionals which possess the correct symmetry is proposed