780 research outputs found
Reimagining career guidance: towards a pluralistic perspective
Difficulties concerning the identified mis-match between supply and demand sides of the labour market are discussed. The variability of career guidance services for young people across Europe is illustrated together with policy initiatives in some cases leading to problems of professional identity and limited support to clients of the service. The risks associated with a monoculture of ‘one size fits all’ approach to guidance practice are discussed. The principles of pluralistic approaches to counselling are discussed with the suggestion that this might prove to be a fertile way forward for career guidance practice
The further study on the accuracy of DEM terrain representation
2003-2004 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe
Preparation of Ni–YSZ thin and thick films on metallic interconnects as cell supports. Applications as anode for SOFC
In this work, we propose the preparation of a duplex anodic layer composed of both a thin (100 nm) and a thick film (10 lm) with Ni–YSZ material. The support of this anode is a metallic substrate, which is the interconnect of the SOFC unit cell. The metallic support limits the temperature of thermal treatment at 800 C to keep a good interconnect mechanical behaviour and to reduce corrosion. We have chosen to elaborate anodic coatings by sol–gel route coupled with dip-coating process, which are low cost techniques and allow working with moderate temperatures. Thin films are obtained by dipping interconnect substrate into a sol, and thick films into an optimized slurry. After thermal treatment at only 800 C, anodic coatings are adherent and homogeneous. Thin films have compact microstructures that confer ceramic protective barrier on metal surface. Further coatings of 10 lm thick are porous and constitute the active anodic material
Preparation and thermal conductivity of CuO nanofluid via a wet chemical method
In this article, a wet chemical method was developed to prepare stable CuO nanofluids. The influences of synthesis parameters, such as kinds and amounts of copper salts, reaction time, were studied. The thermal conductivities of CuO nanofluids were also investigated. The results showed that different copper salts resulted in different particle morphology. The concentration of copper acetate and reaction time affected the size and shape of clusters of primary nanoparticles. Nanofluids with different microstructures could be obtained by changing the synthesis parameters. The thermal conductivities of CuO nanofluids increased with the increase of particle loading
Inhibition of Cardiac Sympathetic Afferent Reflex and Sympathetic Activity by Baroreceptor and Vagal Afferent Inputs in Chronic Heart Failure
BACKGROUND: Cardiac sympathetic afferent reflex (CSAR) contributes to sympathetic activation and angiotensin II (Ang II) in paraventricular nucleus (PVN) augments the CSAR in vagotomized (VT) and baroreceptor denervated (BD) rats with chronic heart failure (CHF). This study was designed to determine whether it is true in intact (INT) rats with CHF and to determine the effects of cardiac and baroreceptor afferents on the CSAR and sympathetic activity in CHF. METHODOLOGY/PRINCIPAL FINDINGS: Sham-operated (Sham) or coronary ligation-induced CHF rats were respectively subjected to BD+VT, VT, cardiac sympathetic denervation (CSD) or INT. Under anesthesia, renal sympathetic nerve activity (RSNA) and mean arterial pressure (MAP) were recorded, and the CSAR was evaluated by the RSNA and MAP responses to epicardial application of capsaicin. Either CSAR or the responses of RSNA, MAP and CSAR to Ang II in PVN were enhanced in CHF rats treated with BD+VT, VT or INT. Treatment with VT or BD+VT potentiated the CSAR and the CSAR responses to Ang II in both Sham and CHF rats. Treatment with CSD reversed the capsaicin-induced RSNA and MAP changes and the CSAR responses to Ang II in both Sham and CHF rats, and reduced the RSNA and MAP responses to Ang II only in CHF rats. CONCLUSIONS: The CSAR and the CSAR responses to Ang II in PVN are enhanced in intact CHF rats. Baroreceptor and vagal afferent activities inhibit CSAR and the CSAR responses to Ang II in intact Sham and CHF rats
Recommended from our members
A mobile assisted coverage hole patching scheme based on particle swarm optimization for WSNs
Wireless sensor networks (WSNs) have drawn much research attention in recent years due to the superior performance in multiple applications, such as military and industrial monitoring, smart home, disaster restoration etc. In such applications, massive sensor nodes are randomly deployed and they remain static after the deployment, to fully cover the target sensing area. This will usually cause coverage redundancy or coverage hole problem. In order to effectively deploy sensors to cover whole area, we present a novel node deployment algorithm based on mobile sensors. First, sensor nodes are randomly deployed in target area, and they remain static or switch to the sleep mode after deployment. Second, we partition the network into grids and calculate the coverage rate of each grid. We select grids with lower coverage rate as candidate grids. Finally, we awake mobile sensors from sleep mode to fix coverage hole, particle swarm optimization (PSO) algorithm is used to calculate moving position of mobile sensors. Simulation results show that our algorithm can effectively improve the coverage rate of WSNs
In-situ FT-IR study of high pressure syngas conversion over Rh/SiO2 and Rh/NaY catalysts
High pressure syngas [V(CO) : V(H-2) = 1] conversion over unpromoted Rh catalyst supported on silica and zeolite NaY were studied at 250 degreesC with an in-situ. IR cell that avoided contamination of iron carbonyls. Change of the syngas pressure produced no effect on the IR spectrum of Rh/SiO2; bridged and linear CO on Rh clusters were the only detectable surface species under 0.1 to 1.0 MPa of flowing syngas. In addition to the bridged and linear CO species, two types of dicarbonyls [Rh(I)(CO)(2)] and a small amount of Rh-6(CO)(16) were formed when Rh/NaY was exposed to 0.1 MPa syngas. Increasing of the syngas pressure to 1. 0 MPa over Rh/NaY resulted in transformation of the dicarbonyls to Rh-6(CO)(16) and probably a mononuclear medium carbonyl featuring an absorption 2042 cm(-1). The detectable reaction products adsorbed on Rh/NaY catalyst under 1.0 MPa were monodentate and bidentate acetates. These surface species were maintained even after releasing the syngas pressure back to 0.1 MPa. Thus, a remarkable difference exists in the effect of syngas pressure on the strtucture of Rh catalysts: reconstruction of Rh catalyst under high pressure of syngas occurs in zeolite NaY but not on silica. Reactivity of the adsorbed surface species toward hydrogen after the catalyst reconstruction suggests that the monodentate acetate groups are responsible for the selective formation of acetic acid from syngas over the Rh/NaY catalyst
Cyclic AMP-Dependent Protein Kinase A Regulates the Alternative Splicing of CaMKIIδ
Ca2+/calmodulin-dependent protein kinase (CaMK) IIδ is predominantly expressed in the heart. There are three isoforms of CaMKIIδ resulting from the alternative splicing of exons 14, 15, and 16 of its pre-mRNA, which is regulated by the splicing factor SF2/ASF. Inclusion of exons 15 and 16 or of exon 14 generates δA or δB isoform. The exclusion of all three exons gives rise to δC isoform, which is selectively increased in pressure-overload-induced hypertrophy. Overexpression of either δB or δC induces hypertrophy and heart failure, suggesting their specific role in the pathogenesis of hypertrophy and heart failure. It is well known that the β-adrenergic-cyclic AMP-dependent protein kinase A (PKA) pathway is implicated in heart failure. To determine the role of PKA in the alternative splicing of CaMKIIδ, we constructed mini-CaMKIIδ genes and used these genes to investigate the regulation of the alternative splicing of CaMKIIδ by PKA in cultured cells. We found that PKA promoted the exclusion of exons 14, 15, and 16 of CaMKIIδ, resulting in an increase in δC isoform. PKA interacted with and phosphorylated SF2/ASF, and enhanced SF2/ASF's activity to promote the exclusion of exons 14, 15, and 16 of CaMKIIδ, leading to a further increase in the expression of δC isoform. These findings suggest that abnormality in β-adrenergic-PKA signaling may contribute to cardiomyopathy and heart failure through dysregulation in the alternative splicing of CaMKIIδ exons 14, 15, and 16 and up-regulation of CaMKIIδC
Synthesis and characterization of CuO nanowires by a simple wet chemical method
We report a successful synthesis of copper oxide nanowires with an average diameter of 90 nm and lengths of several micrometers by using a simple and inexpensive wet chemical method. The CuO nanowires prepared via this method are advantageous for industrial applications which require mass production and low thermal budget technique. It is found that the concentration and the quantity of precursors are the critical factors for obtaining the desired one-dimensional morphology. Field emission scanning electron microscopy images indicate the influence of thioglycerol on the dispersity of the prepared CuO nanowires possibly due to the stabilization effect of the surface caused by the organic molecule thioglycerol. The Fourier transform infrared spectrum analysis, energy dispersive X-ray analysis, X-ray diffraction analysis, and X-ray photoemission spectrum analysis confirm clearly the formation of a pure phase high-quality CuO with monoclinic crystal structure
- …