802 research outputs found
Retroperitoneoskopische Nierenchirurgie: Indikationen, Technik und eigene Erfahrungen nach 360 Eingriffen
Zusammenfassung: Die retroperitoneoskopische Operationstechnik überzeugt durch den schnellen, direkten und einfachen Zugang ins Retroperitoneum und zu den Nierengefäßen unter Umgehung des Peritonealraums. Wir beschreiben unsere Operationstechnik und diskutieren Vor- und Nachteile der Retroperitoneoskopie. Unsere Erfahrungen mit dieser Operationstechnik bei insgesamt 360 retroperitoneoskopischen Eingriffen werden vorgestellt: Nephrektomie, Nierenteilresektion, Lebendnierenspende, Kryotherapie von Nierentumoren, Pyelonplastik sowie Adrenalektomie und weitere Indikationen werden dargestellt. Wir zeigen, welche Eingriffe sich zum Einstieg in die Technik eignen und auf was geachtet werden mus
Benigne zystische Raumforderungen des Hodens: Eine Übersicht
Zusammenfassung: Hodenzysten werden im Rahmen der skrotalen Sonographie zunehmend diagnostiziert. Grund hierfür ist u.a. die flächendeckende Verfügbarkeit moderner, hochauflösender Ultraschallgeräte. Differentialdiagnostisch und ätiologisch sind benigne und maligne Erkrankungen mit testikulärer Zystenbildung voneinander zu unterscheiden. Benigne Krankheitsbilder mit zystischen Raumforderungen des Hodens sind die tubuläre Ektasie des Rete testis, die zystische Dysplasie, Epidermoidzysten, einfache intraparenchymatöse Hodenzysten und Zysten der Tunica albuginea. Die testikuläre Dermoidzyste, die lange Zeit zu Unrecht als potentiell maligne angesehen wurde, ist ebenfalls als benigne zu klassifizieren. Bei Diagnose einer benignen zystischen Raumforderung des Hodens kann in den meisten Fällen eine organerhaltende operative Therapie oder ein abwartendes, überwachendes Procedere empfohlen werde
Photoselektive Vaporisation der Prostata: Erfahrungen mit Prostataadenomen >80cm3
Zusammenfassung: Hintergrund: Wir berichten über unsere Erfahrungen mit der photoselektiven Vaporisation der Prostata (PVP) bei Patienten mit symptomatischer benigner Prostatahyperplasie (BPH) und Prostataadenomen >80cm3. Patienten und Methode: 201Patienten mit BPH wurden in die Studie eingeschlossen; 51 (25,4%) Patienten hatten ein Prostatavolumen >80cm3 und 150 (74,6%) Patienten ein Volumen 80cm3 stellt die PVP eine durchführbare Therapieoption da
An immediate-late gene expression module decodes ERK signal duration
The RAF-MEK-ERK signalling pathway controls fundamental, often opposing cellular processes such as proliferation and apoptosis. Signal duration has been identified to play a decisive role in these cell fate decisions. However, it remains unclear how the different early and late responding gene expression modules can discriminate short and long signals. We obtained both protein phosphorylation and gene expression time course data from HEK293 cells carrying an inducible construct of the proto-oncogene RAF By mathematical modelling, we identified a new gene expression module of immediate-late genes (ILGs) distinct in gene expression dynamics and function. We find that mRNA longevity enables these ILGs to respond late and thus translate ERK signal duration into response amplitude. Despite their late response, their GC-rich promoter structure suggested and metabolic labelling with 4SU confirmed that transcription of ILGs is induced immediately. A comparative analysis shows that the principle of duration decoding is conserved in PC12 cells and MCF7 cells, two paradigm cell systems for ERK signal duration. Altogether, our findings suggest that ILGs function as a gene expression module to decode ERK signal duration
B0 -> D*- a1+: Chirality tests and resolving an ambiguity in 2\beta+\gamma
We point out that the decays of B mesons into a vector meson and an
axial-vector meson can distinguish between left and right-handed polarized
mesons, in contrast to decays into two vector mesons. Measurements in B0 ->
D*-a1+ are proposed for testing factorization and the V-A structure of the weak
b -> c current, and for resolving a discrete ambiguity in 2\beta + \gamma.Comment: 4 page
Exploring CP Violation with Decays
We point out that the pure ``tree'' decays are
particularly well suited to extract the CKM angle through amplitude
relations. In contrast to conceptually similar strategies using or decays, the advantage of the approach is that
the corresponding triangles have three sides of comparable length and do not
involve small amplitudes. Decays of the type -- the
-spin counterparts of -- can be added to the
analysis, as well as channels, where the - and -mesons are
replaced by higher resonances.Comment: 9 pages, LaTeX, 3 figures, reference adde
Relations among neutrino observables in the light of a large theta_13 angle
The recent T2K and MINOS indications for a "large" theta_13 neutrino mixing
angle can be accommodated in principle by an infinite number of Yukawa flavour
structures in the seesaw model. Without considering any explicit flavour
symmetry, there is an instructive exercise one can do: to determine the
simplest flavour structures which can account for the data with a minimum
number of parameters, simply assuming these parameters to be uncorrelated. This
approach points towards a limited number of simple structures which show the
minimum complexity a neutrino mass model must generally involve to account for
the data. These basic structures essentially lead to only 4 relations between
the neutrino observables. We emphasize that 2 of these relations, |sin
theta_13|=(tan theta_23/cos delta)*(1-tan theta_12)/(1+tan theta_12) and |sin
theta_13| = sin theta_12 R^1/4, with R= Delta m^2_21/Delta m^2_32, have several
distinctive properties. First, they hold not only with a minimum number of
parameters, but also for complete classes of more general models. Second, any
value of theta_13 within the T2K and MINOS ranges can be obtained from these
relations by taking into account small perturbations. Third, they turn out to
be the pivot relations of models with approximate conservation of lepton
number, which allow the seesaw interactions to induce observable flavour
violating processes, such as mu -> e gamma and tau -> mu gamma. Finally, in
specific cases of this kind, these structures have the rather unique property
to allow a full reconstruction of the seesaw Lagrangian from low energy data.Comment: 13 pages, 3 figure
Fitting Neutrino Physics with a U(1)_R Lepton Number
We study neutrino physics in the context of a supersymmetric model where a
continuous R-symmetry is identified with the total Lepton Number and one
sneutrino can thus play the role of the down type Higgs. We show that
R-breaking effects communicated to the visible sector by Anomaly Mediation can
reproduce neutrino masses and mixing solely via radiative contributions,
without requiring any additional degree of freedom. In particular, a relatively
large reactor angle (as recently observed by the Daya Bay collaboration) can be
accommodated in ample regions of the parameter space. On the contrary, if the
R-breaking is communicated to the visible sector by gravitational effects at
the Planck scale, additional particles are necessary to accommodate neutrino
data.Comment: 19 pages, 3 figures; v2: references added, constraints updated,
overall conclusions unchange
Comparison of the roll-plate and sonication techniques in the diagnosis of microbial ureteral stent colonisation: results of the first prospective randomised study
Background: Microbial ureteral stent colonisation (MUSC) is one leading risk factor for complications associated with ureteral stent placement. As MUSC remains frequently undetected by standard urine cultures, its definitive diagnosis depends on microbiological investigation of the stent. However, a standard reference laboratory technique for studying MUSC is still lacking. Materials and methods: A total of 271 ureteral stents removed from 199 consecutive patients were investigated. Urine samples were obtained prior to device removal. Stents were divided into four parts. Each part was separately processed by the microbiology laboratory within 6h. Ureteral stents were randomly allocated to roll-plate or sonication, respectively, and analysed using standard microbiological techniques. Demographic and clinical data were prospectively collected using a standard case-report form. Results: Overall, roll-plate showed a higher detection rate of MUSC compared with sonication (35 vs. 28%, p<0.05) and urine culture (35 vs. 8%, p<0.05). No inferiority of Maki's technique was observed even when stents were stratified according to indwelling time below or above 30days. Compared with roll-plate, sonication commonly failed to detect Enterococcus spp., coagulase-negative staphylococci (CoNS) and Enterobacteriaceae. In addition, sonication required more hands-on time, more equipment and higher training than roll-plate in the laboratory. Conclusions: This prospective randomised study demonstrates the superiority of Maki's roll-plate technique over sonication in the diagnosis of MUSC and that urine culture is less sensitive than both methods. The higher detection rate, simplicity and cost-effectiveness render roll-plate the methodology of choice for routine clinical investigation as well as basic laboratory researc
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