The analysis of factors associated with progression of isolated terminal ileal lesions.

To assess the factors associated with the progression of isolated terminal ileal lesions (ITILs) at colonoscopy in Chinese patients.Patients diagnosed with ITILs were enrolled. The ileoscopy was performed by two experienced gastroenterologists every 52 weeks. A logistic regression analysis was used to elucidate the factors associated with Crohn's disease (CD) and mucosal healing. A log rank test was used to assess the differences of the cumulative proportion of CD and mucosal healing in different groups at different times.(1) A total of 34 patients were included and no patient had taken nonsteroidal anti-inflammatory drug in the last 6 months; eight (23.5%) patients had a clinical diagnosis of CD, 14 (41.2%) patients achieved mucosal healing, and 12 (35.3%) patients showed no significant changes in the lesions at last follow-up. (2) The logistic regression analysis showed that only abdominal pain was a factor in the ITIL disease outcomes. (3) The cumulative proportion of CD in the abdominal pain group after 3 years was statistically higher than that in the non-abdominal pain group (42.7% vs. 6.2%, χ2 = 10.129, P = 0.001). However, the cumulative proportion of mucosal healing in the non-abdominal pain group was statistically higher than that in the abdominal pain group (73.3% vs. 5.6%, χ2 = 5.225, P = 0.022). (4) The numbers of lesions observed on the initial colonoscopy exams and the initial histologic findings were not related to the ITIL disease outcomes.Clinical symptoms may be related to ITIL disease outcomes. Patients with abdominal pain had a high likelihood of CD, whereas those without abdominal pain had a high likelihood of mucosal healing

The expression and clinical significance of PLK1/p-PLK1 protein in NK/T cell Lymphoma

Abstract Aims To investigate the expression of polo-like kinase 1 protein (PLK1) and its phosphorylation level (p-PLK1) in extranodal NK/T cell lymphoma (NKTCL) and their correlation with clinical characteristics and prognosis. Methods We collected 40 cases of NKTCL (referred to as the experimental group), which received diagnoses at the First Affiliated Hospital of Zhengzhou University between January 2018 and October 2022. Concurrently, we assembled a control group, including 20 cases afflicted with nasopharyngeal mucosal lymphoid hyperplasia diseases during the same timeframe. We utilized immunohistochemical techniques to evaluate the levels of PLK1 and p-PLK1 expression in both the experimental and control groups. Subsequently, we conducted an analysis to identify disparities in their expression and explore their relationships with clinical characteristics and patient prognosis. Results Among the 40 NKTCL patients, there were 27 males and 11 females, with a median age of 51 years (range 12–80 years). Compared to the control group, the tissue samples of NKTCL patients exhibited significantly elevated expression levels and active phosphorylation levels of PLK1 (P  0.05). Grouping based on PLK1 and p-PLK1 immunohistochemical H-scores revealed that the high expression of PLK1 and p-PLK1 was associated with poor prognosis. Conclusions The expression levels and active phosphorylation levels of PLK1 were significantly increased in NK/T cell lymphoma, and patients with overexpression of PLK1 and p-PLK1 had a poorer prognosis

Initial colonoscopic images in the 34 patients.

<p>Erosions surrounded by normal mucosa (1a), edematous mucosa (1b), and covered by thin or faint exudates (1a, 1b, and 1c).</p

The cumulative proportions of CD in the 34 patients.

<p>The cumulative proportions of CD in the abdominal pain group in the 1^st, 2^nd, and 3^rd years of follow-up were 6%, 31% and 43%, respectively, and the proportions in the non-abdominal pain group were 0, 0, and 6%, respectively. Moreover, the cumulative proportion of CD in the abdominal pain group after 3 years was statistically higher than that in the non-abdominal pain group (43% <i>vs.</i> 6%, <i>χ²</i> = 10.129, <i>P</i> = 0.001). CD, Crohn's disease.</p

The Demographic Characteristics of the 34 Patients.

<p>The Demographic Characteristics of the 34 Patients.</p

Possible Drugs for a Dominant Symptom in Patients.

<p>qd, quaque die; bid, bis in die; qid, quater in die; hs, hora somni; ac, ante cibum; oz, ounce.</p

The cumulative proportions of mucosal healing in the 34 patients.

<p>The cumulative proportions of mucosal healing in the non-abdominal pain group in the 1^st, 2^nd, 3^rd, and 4^th years of follow-up were 6%, 28%, 56% and 73%, respectively, and the proportions in the abdominal pain group were 6%, 6%, 6% and 6%, respectively. Moreover, the cumulative proportion of mucosal healing in the non-abdominal pain group after 4 years was statistically higher than that in the abdominal pain group (73% <i>vs.</i> 6%, <i>χ²</i> = 5.225, <i>P</i> = 0.022).</p