Next-generation therapeutic bacteria for treatment of obesity, diabetes, and other endocrine diseases

The human gut microbiota has appeared as an important factor affecting host health and intestinal bacteria have recently emerged as potential therapeutics to treat diabetes and other endocrine dis-eases. These mainly anaerobic bacteria have been identified either via comparative "omics" analysis of the intestinal microbiota in healthy and diseased subjects or of data collected by fecal microbiota transplantation studies. Both approaches require advanced and in-depth sequencing technologies to perform massive genomic screening to select bacteria with potential benefits. It has been shown that these potentially therapeutic bacteria can either pro -duce bioactive products that directly influence the host patho-physiology and endocrine systems or produce specific signaling molecules that may do so. These bioactive compounds can be formed via degradation of dietary or host-derived components or the conversion of intermediate compounds produced by fermen-tation of intestinal bacteria. Several of these bacteria have shown causality in preclinical models and entered clinical phase studies, while their mode of action is being analyzed. In this review, we summarize the research on the most promising bacterial candidates with therapeutic properties with a specific focus on diabetes . (c) 2021 Published by Elsevier Ltd.Peer reviewe

Honey On Our Honeymoon

https://digitalcommons.library.umaine.edu/mmb-vp/5284/thumbnail.jp

I Love The Girl My Father Loved And Mother Is Her Name

https://digitalcommons.library.umaine.edu/mmb-vp/4344/thumbnail.jp

Wicked Little Chichis

https://digitalcommons.library.umaine.edu/mmb-vp/3766/thumbnail.jp

The Mysterius Kiss

https://digitalcommons.library.umaine.edu/mmb-vp/3319/thumbnail.jp

Geometrical CP violation in multi-Higgs models

We introduce several methods to obtain calculable phases with geometrical values that are independent of arbitrary parameters in the scalar potential. These phases depend on the number of scalars and on the order of the discrete non-Abelian group considered. Using these methods we present new geometrical CP violation candidates with vacuum expectation values that must violate CP (the transformation that would make them CP conserving is not a symmetry of the potential). We also extend to non-renormalisable potentials the proof that more than two scalars are needed to obtain these geometrical CP violation candidates.Comment: 8 pages, 2 figures. v2: table added, accepted by JHE

Stability of boundaries between response options of response scales: Does 'very happy' remain equally happy over the years?

The differences between response scales in number and wording of response options make it hard to compare data from survey research and to perform research syntheses. A recent method that we have developed to tackle this problem is rooted in the idea that the transition points on a bounded continuum, on which verbal response options from a primary scale transit from one point to another, for instance from ‘happy’ to ‘very happy’, remain unchanged over time. The idea behind this is that although people may change their perception of, for example, their own happiness intensity over time, they are assumed not to change the degree of appreciation they attribute to the terms used to label response options. This is an important assumption for research syntheses that requires that everything remains unchanged, except for the change of interest. It means that if our method is applied to measurements at distinct points in time, differences in estimates of the mean and standard deviation can be attributed solely to changes in the frequency distributions on the primary scale. In this paper we apply the method to happiness and show that it is reasonable to assume that the transition points between the response options are stable over time. Keywords: verbal response scales; comparability; scale transformation; beta distribution; reference distribution; research synthesi

High prevalence of mixed infections by Helicobacter pylori in Hong Kong: Metronidazole sensitivity and overall genotype

Background: Diversity in metronidazole susceptibility and genotypes of Helicobacter pylori have been reported with varying results in different areas. Aims: To investigate the prevalence of multiple strain infection in a symptomatic Chinese population and to determine the metronidazole susceptibility pattern and genotypic characteristics of these infecting strains. Methods: Gastric biopsies from antrum, body and cardia were taken during upper endoscopy in symptomatic patients referred to our department. Pooled cultures and single colony isolates were obtained and tested for metronidazole susceptibility and random amplified polymorphic DNA (RAPD) fingerprint patterns. Results: A total of 461 isolates were successfully cultured from 46 patients. Fifty-seven per cent of subjects had metronidazole-resistant strains. Among them, 77% carried a mixture of sensitive and resistant strains, non-uniformly distributed in the gastric mucosa. Mixed genotypes were found by RAPD typing in 24% of subjects. These did not correlate with the metronidazole susceptibility/resistance pattern. Conclusion: H. pylori infections with mixed metronidazole sensitive/resistant strains and mixed genotypes are common in Hong Kong. This makes it prudent to use bacterial strains from several biopsy sites when testing for traits such as drug resistance or virulence in relation to disease.postprin

Effect of alloying on mechanical properties of as cast ferritic nodular cast irons

The development of low temperature applications for ferritic nodular cast irons calls for improved materials in the as cast state, e.g. for off-shore windmills components. Within this line of work, a series of 68 castings were prepared with the same casting procedure and slight changes in composition. The tensile properties at room temperature, as well as the impact energy for rupture at room temperature, 220 °C and 240 °C, were measured. Outputs from multivariate analysis performed on the data are then discussed and compared to literature results, putting emphasis on the properties of the ferritic matrix