Sonic Hedgehog and Notch Signaling Can Cooperate to Regulate Neurogenic Divisions of Neocortical Progenitors

Innate lymphoid cells (ILCs) and innate-like lymphocytes have important roles in immune responses in the context of infection, cancer, and autoimmunity. The factors involved in driving the differentiation and function of these cell types remain to be clearly defined. There are several cellular signaling pathways involved in embryogenesis, which continue to function in adult tissue. In particular, the WNT, NOTCH, and Hedgehog signaling pathways are emerging as regulators of hematopoietic cell development and differentiation. This review discusses the currently known roles of WNT, NOTCH, and Hedgehog signaling in the differentiation and function of ILCs and innate-like lymphocytes

<i>Nek1</i>^{<i>kat2j/kat2j</i>} spermatocytes and oocytes show aberrant localization of Adducin 1 (ADD1) on meiosis I spindles.

<p>(a) IF against ADD1 (red), β-tubulin (green) and DAPI (magenta) on spermatocytes from wildtype (left) and <i>Nek1</i>^{<i>kat2j/kat2j</i>} mice (right) in coronal (top) and transverse (bottom) planes. Arrowheads indicate examples of ADD1 foci. Quantitation of ADD1 focus counts per nucleus are given in panel (b). (c) IF against ADD1 (red), β-tubulin (green) and DAPI (magenta) in oocytes of both wildtype and mutant mice. Arrowheads indicate examples of ADD1 foci. Quantitation of ADD1 focus counts per nucleus are given in panel (d). All values are focus counts per spindle and black bars denote means ± Standard deviation. * Indicates statistically significant differences (Unpaired t test p < 0.05).</p