Biography of Objects. Aspekte eines kulturhistorischen Konzepts

Biography of Objects – Das Thema dieses Bandes trägt der zuletzt wieder verstärkt erkennbaren Hinwendung der Geistes- und Kulturwissenschaften zur Welt des Materiellen als einer wesentlichen Instanz des Kultu- rellen Rechnung. Der Band vereint die Beiträge eines 2014 am Internatio- nalen Kolleg Morphomata in Köln veranstalteten Work- shops gleichen Titels, der Vertreter aus unterschiedlichen Disziplinen – Ethnologie, Ur- und Frühgeschichte, Klassische Archäologie, Kunstgeschichte, Germanistik – zur Diskussion zusammenführte. Zu Wort kommen somit verschiedene, durchaus konträre Positionen zu dieser Perspektive der ‚Objektbiographie‘ auf Materielle Kultur und Objektschicksale. Damit eröffnet der Band auch einen Einblick in die Reflexion und aktuelle Kritik dieses Deutungsansatzes in den verschiedenen Fächern, sowie Versuche, diesen Zugang zu einem möglichen Verständnis des Materiellen für spezifische Fragestellungen fruchtbar zu machen

Monitoring Guidance for Underwater Noise in European Seas- Part II: Monitoring Guidance Specifications

This document has been prepared by the Technical Subgroup on Underwater Noise and other forms of Energy (TSG Noise), established in 2010 by the Marine Directors, i.e. the representatives of directorates or units in European Union Member States, Acceding Countries, Candidate Countries and EFTA Member States dealing with or responsible for marine issues. In December 2011, the Marine Directors requested the TSG Noise to provide monitoring guidance that could be used by Member States in establishing monitoring schemes to meet the needs of the Marine Strategy Framework Directive indicators for underwater noise in their marine waters. This document presents the recommendations and information needed to commence the monitoring required for underwater noise.JRC.H.1-Water Resource

Monitoring Guidance for Underwater Noise in European Seas - Part I: Executive Summary

This document has been prepared by the Technical Subgroup on Underwater Noise and other forms of Energy (TSG Noise), established in 2010 by the Marine Directors, i.e. the representatives of directorates or units in European Union Member States, Acceding Countries, Candidate Countries and EFTA Member States dealing with or responsible for marine issues. In December 2011, the Marine Directors requested the TSG Noise to provide monitoring guidance that could be used by Member States in establishing monitoring schemes to meet the needs of the Marine Strategy Framework Directive indicators for underwater noise in their marine waters. This document presents the key conclusions and recommendations that support the implementation of the practical guidance to commence the monitoring required for underwater noise.JRC.H.1-Water Resource

Das Bild der Jahreszeiten im Wandel der Kulturen und Zeiten

Warum gibt es vier Jahreszeiten? Gibt oder gab es Kulturen, bei denen nicht vier Jahreszeiten das Jahr ausmachen? Was bedeutet das wiederum für unsere fest verankerte Vorstellung von den vier Jahreszeiten? Welches Zeitmodell steht hinter der Idee der Jahreszeiten? Und: was bedeutet eine solche Einteilung in unserer Kulturepoche, in der die Grenzen zwischen den Jahreszeiten zunehmend verschwimmen? Solchen und weiteren Fragen zum Thema »Jahreszeiten im Wandel der Kulturen und Zeiten« widmet sich der Sammelband, der auf eine im Sommer 2011 in Köln veranstaltete Tagung zurückgeht. Entsprechend der Zielsetzung des Internationalen Kollegs Morphomata behandelt er das Thema sowohl diachron als auch im Kulturvergleich. Anhand von Fallbeispielen wird erstmalig ein umfassender Einblick in die divergierenden Bilder der Jahreszeiten in Meteorologie, Ritual und Kunst geboten, wobei neben den ›klassischen‹ Jahreszeitenvorstellungen (von der römischen Antike bis in die Kunst der Gegenwart) auch von diesem für uns ›traditionellen‹ Modell abweichende Jahreszeitenvorstellungen (etwa in Mesopotamien, Ägypten, Altamerika, aber auch im antiken Griechenland) in den Blick genommen werden

Correction to: Predictive risk factors for lymph node metastasis in patients with resected non-small cell lung cancer: a case control study

The original article [1] contains slight errors whereby several terms in the first column of Tables 1, 2, and 3 have an erroneous ‘p’ preceding them

Predictive risk factors for lymph node metastasis in patients with resected non-small cell lung cancer: a case control study

Abstract Background Estimation of lymph node status is essential in order to determine precise therapy for patients with non-small cell lung cancer (NSCLC). Furthermore, lymph node involvement is a very powerful prognostic factor in these patients. In this analysis, we aim to evaluate the predictive factors for lymph node metastasis in NSCLC-patients. Methods In a prospectively-established database, we analyzed all data of patients with NSCLC, who underwent oncological surgical resections from 01/2007 to 12/2016, retrospectively. The correlation between clinicopathological parameters and lymph node metastasis was investigated by using univariate and binary logistic regression analysis. Results In this study, we operated on 204 consecutive patients, 142 men (71.7%) and 56 women (28.3%). Lymph node metastases were detected in 38.2% (78/204). Preoperatively, central tumor localization (OR = 2.6, 95% CI = 1.3–5.1, P = 0.005) and tumor size > 3 cm (OR = 2.5, 95% CI = 1.3–4.4, P = 0.005) were found to be significant predictive factors for lymph node metastasis. Postoperatively, multivariate analysis showed that intratumoral lymph vessel invasion (L1-status) (OR = 17.3, 95% CI = 5.1–58.4, P <  0.001) along with the central tumor localization (OR = 2.8, 95% CI = 1.4–5.8, P = 0.004) were significantly associated with lymph node metastasis. In small size tumors (≤3 cm), two predictive factors for lymph node metastasis were found: central tumor localization (OR = 19.4, 95% = 2.1–186.4, P = 0.01) and L1-status (OR = 43.9, 95% CI = 3.6–529.4, P = 0.003). Conclusions A precise pre- and intraoperative assessment of the lymph node status is essential in patients with larger sized tumors and central localization. Furthermore, L1-status is a highly significant risk factor for lymph node metastasis in NSCLC-Patients. Therefore, an adjuvant therapy in patients with L1-status and pNX category should be considered

Oral Cancer Diagnosis by Mechanical Phenotyping

Oral squamous cell carcinomas are among the 10 most common cancers and have a 50% lethality rate after 5 years. Despite easy access to the oral cavity for cancer screening, the main limitations to successful treatment are uncertain prognostic criteria for (pre-)malignant lesions. Identifying a functional cellular marker may represent a significant improvement for diagnosis and treatment. Toward this goal, mechanical phenotyping of individual cells is a novel approach to detect cytoskeletal changes, which are diagnostic for malignant change. The compliance of cells from cell lines and primary samples of healthy donors and cancer patients was measured using a microfluidic optical stretcher. Cancer cells showed significantly different mechanical behavior, with a higher mean deformability and increased variance. Cancer cells (n approximate to 30 cells measured from each patient) were on average 3.5 times more compliant than those of healthy donors [D-normal = (4.43 +/- 0.68) 10(-3) Pa-1; D-cancer = (15.8 +/- 1.5) 10(-3) Pa-1; p < 0.01]. The diagnosis results of the patient samples were confirmed by standard histopathology. The generality of these findings was supported by measurements of two normal and four cancer oral epithelial cell lines. Our results indicate that mechanical phenotyping is a sensible, label-free approach for classifying cancer cells to enable broad screening of suspicious lesions in the oral cavity. It could in principle be applied to any cancer to aid conventional diagnostic procedures. [Cancer Res 2009;69(5):1728-32

A human REPIN1 gene variant: Genetic risk factor for the development of nonalcoholic fatty liver disease.

OBJECTIVES: We tested the hypothesis that a genetic deletion (Del) variant in the REPIN1 gene is associated with the severity of nonalcoholic fatty liver disease (NAFLD) in humans.METHODS: Sixty-three donors of liver biopsies from individuals with obesity and different degrees of NAFLD and fibrosis were screened for a Del REPIN1 gene variant and liver REPIN1 mRNA expression.RESULTS: In 8 homozygous Del carriers, we found significantly lower NAFLD activity and fibrosis scores compared with 55 wild-type allele carriers.DISCUSSION: A Del variant of REPIN1 may be associated with a lower risk of the development of NAFLD