682 research outputs found
Lifting of the Landau level degeneracy in graphene devices in a tilted magnetic field
We report on transport and capacitance measurements of graphene devices in
magnetic fields up to 30 T. In both techniques, we observe the full splitting
of Landau levels and we employ tilted field experiments to address the origin
of the observed broken symmetry states. In the lowest energy level, the spin
degeneracy is removed at filling factors and we observe an enhanced
energy gap. In the higher levels, the valley degeneracy is removed at odd
filling factors while spin polarized states are formed at even . Although
the observation of odd filling factors in the higher levels points towards the
spontaneous origin of the splitting, we find that the main contribution to the
gap at , and is due to the Zeeman energy.Comment: 5 pages, 4 figure
Shedding New Light on Kaon-Nucleon/Nuclei Interaction and Its Astrophysical Implications with the AMADEUS Experiment at DAFNE
The AMADEUS experiment deals with the investigation of the low-energy
kaon-nuclei hadronic interaction at the DA{\Phi}NE collider at LNF-INFN, which
is fundamental to respond longstanding questions in the non-perturbative QCD
strangeness sector. The antikaon-nucleon potential is investigated searching
for signals from possible bound kaonic clusters, which would open the
possibility for the formation of cold dense baryonic matter. The confirmation
of this scenario may imply a fundamental role of strangeness in astrophysics.
AMADEUS step 0 consisted in the reanalysis of 2004/2005 KLOE dataset,
exploiting K- absorptions in H, 4He, 9Be and 12C in the setup materials. In
this paper, together with a review on the multi-nucleon K- absorption and the
particle identification procedure, the first results on the {\Sigma}0-p channel
will be presented including a statistical analysis on the possible accomodation
of a deeply bound stateComment: 6 pages, 2 figure, 1 table, HADRON 2015 conferenc
Inverse remodelling of K2P3.1 K+ channel expression and action potential duration in left ventricular dysfunction and atrial fibrillation: implications for patient-specific antiarrhythmic drug therapy
AIMS: Atrial fibrillation (AF) prevalence increases with advanced stages of left ventricular (LV) dysfunction. Remote proarrhythmic effects of ventricular dysfunction on atrial electrophysiology remain incompletely understood. We hypothesized that repolarizing K2P3.1 K+ channels, previously implicated in AF pathophysiology, may contribute to shaping the atrial action potential (AP), forming a specific electrical substrate with LV dysfunction that might represent a target for personalized antiarrhythmic therapy. METHODS AND RESULTS: A total of 175 patients exhibiting different stages of LV dysfunction were included. Ion channel expression was quantified by real-time polymerase chain reaction and Western blot. Membrane currents and APs were recorded from atrial cardiomyocytes using the patch-clamp technique. Severely reduced LV function was associated with decreased atrial K2P3.1 expression in sinus rhythm patients. In contrast, chronic (c)AF resulted in increased K2P3.1 levels, but paroxysmal (p)AF was not linked to significant K2P3.1 remodelling. LV dysfunction-related suppression of K2P3.1 currents prolonged atrial AP duration (APD) compared with patients with preserved LV function. In individuals with concomitant LV dysfunction and cAF, APD was determined by LV dysfunction-associated prolongation and by cAF-dependent shortening, respectively, consistent with changes in K2P3.1 abundance. K2P3.1 inhibition attenuated APD shortening in cAF patients irrespective of LV function, whereas in pAF subjects with severely reduced LV function, K2P3.1 blockade resulted in disproportionately high APD prolongation. CONCLUSION: LV dysfunction is associated with reduction of atrial K2P3.1 channel expression, while cAF leads to increased K2P3.1 abundance. Differential remodelling of K2P3.1 and APD provides a basis for patient-tailored antiarrhythmic strategies
Pharmacologic TWIK-Related Acid-Sensitive K+ Channel (TASK-1) Potassium Channel Inhibitor A293 Facilitates Acute Cardioversion of Paroxysmal Atrial Fibrillation in a Porcine Large Animal Model
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