Business and public health collaboration for emergency preparedness in Georgia: a case study

BACKGROUND: Governments may be overwhelmed by a large-scale public health emergency, such as a massive bioterrorist attack or natural disaster, requiring collaboration with businesses and other community partners to respond effectively. In Georgia, public health officials and members of the Business Executives for National Security have successfully collaborated to develop and test procedures for dispensing medications from the Strategic National Stockpile. Lessons learned from this collaboration should be useful to other public health and business leaders interested in developing similar partnerships. METHODS: The authors conducted a case study based on interviews with 26 government, business, and academic participants in this collaboration. RESULTS: The partnership is based on shared objectives to protect public health and assure community cohesion in the wake of a large-scale disaster, on the recognition that acting alone neither public health agencies nor businesses are likely to manage such a response successfully, and on the realization that business and community continuity are intertwined. The partnership has required participants to acknowledge and address multiple challenges, including differences in business and government cultures and operational constraints, such as concerns about the confidentiality of shared information, liability, and the limits of volunteerism. The partnership has been facilitated by a business model based on defining shared objectives, identifying mutual needs and vulnerabilities, developing carefully-defined projects, and evaluating proposed project methods through exercise testing. Through collaborative engagement in progressively more complex projects, increasing trust and understanding have enabled the partners to make significant progress in addressing these challenges. CONCLUSION: As a result of this partnership, essential relationships have been established, substantial private resources and capabilities have been engaged in government preparedness programs, and a model for collaborative, emergency mass dispensing of pharmaceuticals has been developed, tested, and slated for expansion. The lessons learned from this collaboration in Georgia should be considered by other government and business leaders seeking to develop similar partnerships

Analysis of turbomachine viscous losses affected by changes in blade geometry

The effect of changes in blade geometry on the viscous losses in turbomachines is analyzed. The viscous losses can be expressed as a function of three variables: the blade height-to spacing ratio, the solidity, and a blade-height Reynolds number. A method of optimizing the number of blades and the solidity is given. The effect of trailing-edge blockage on blade loss and its effect on the choice of blade number for a particular design are also discussed

Barge Traffic on Kentucky Rivers

Kentucky currently has the second longest navigable inland waterway system in the United States. Prior to the design of a bridge at a specific location on a river, a thorough investigation of barge traffic at that location ust be conducted. This report investigates the barge traffic on all navigable waterways in Kentucky. This report provides the data necessary to develop the risk assessment procedures for Kentucky vessel impact design problems in accordance with the AASHTO Guide Specification and Commentary for Vessel Collision Design of Highway Bridges design Method II. Method II is more rigorous to apply than Method I, but it is recommended by the guide specification for most bridges and should lead to more economical designs. A computer program was written to process the database and calculate the probability based length, width, and capacity for each barge category. Additionally, a second computer program was written to calculate the probability based number of barges in a flotilla column and row, and subsequently categorize that flotilla based upon the barge length and width categories designated by the U.S. Army Corps of Engineers. The equivalent static impact loads were then calculated using the probability based flotilla sizes and tonnages. The calculations for the Maysville, KY bridge over the Ohio River are offered as a design example

Barge Impact Loads for the Maysville Bridge

This report provides the barge equivalent static load distribution data needed to apply method II of vessel impact design for the Maysville, Kentucky bridge over the Ohio River. The information provided in this report is in accordance with the AASHTO Guide Specification and Commentary for Vessel Collision Design of Highway Bridges. A computer program was written to process the database and calculate the probability based length, width., and capacity for each barge category. Additionally, a second computer program was written to calculate the probability based number of barges in a flotilla column and row, and subsequently categorize that flotilla based upon the barge length and width categories designated by the U.S. Army Corps of Engineers. The equivalent static impact loads were then calculated using the probability based flotilla sizes and tonnages. The results indicated 12 barge categories occurring along the Maysville section of the Ohio River. The associated frequencies and impact loads are reported. The equivalent static load for the usually neglected 290 x 54 foot barge was calculated to be a maximum of 8,140 kips with a significant frequency of occurrence of 205 downbound passages per year

Nurses\u27 Alumnae Association Bulletin - Volume 6 Number 10

Financial Report Calendar of Events Attention, Class of 1945! Miss Shafer Retires Review of the Alumnae Association Meetings Institutional Staff Nurses\u27 Section Report of Staff Activites - 1948-1949 The Staff Stockings! Stockings! Stockings! Pop-Up Toaster It\u27s Not Too Soon Any White Elephants? Private Duty Section The Jefferson Hospital Private Duty Nurses\u27 Register Report for Barton Memorial Hospital Progress of the Orthopedic Department Just Under the Date Line Pediatrics at Jefferson Controlled Respiration in Anesthesia Anesthesia Progress Physical Advances at Jefferson During the Past Year The White Haven Division The Clara Melville Scholarship Fund The Relief Fund The Busy Year for the Nurses\u27 Home Committee of the Women\u27s Board The Gray Ladies Memories Lost Miscellaneous Items Medical College News Marriages Births Deaths Condolences Prizes District No. 1 Dues Help! Help! Help! Jap Prison School Spurs Nurse to Win University Degree Twenty Ways to Kill an Organization The Bulletin Committee Attention, Alumnae New Addresse

Nurses\u27 Alumnae Association Bulletin - Volume 7 Number 11

Anna M. Shafer Barton Memorial Division Births Changes in the Ophthalmology Division Change of Address Clara Melville Fund Continental Tour Deceased Digest of Meetings Inter-County Hospitalization Plan Katherine Childs\u27 Letter Lost Members Marriages Miscellaneous Nursing Home Committee\u27s Report Physical Advantages President James L. Kauffman\u27s Letter President\u27s Greeting Private Duty Section Prizes Relief Fund School Nursing Silhouette of a Public Health Nurse Rooming-in of Infant with Mother Staff Activities The Student White Haven Divisio

In Vivo Anti-HIV Activity of the Heparin-Activated Serine Protease Inhibitor Antithrombin III Encapsulated in Lymph-Targeting Immunoliposomes

Endogenous serine protease inhibitors (serpins) are anti-inflammatory mediators with multiple biologic functions. Several serpins have been reported to modulate HIV pathogenesis, or exhibit potent anti-HIV activity in vitro, but the efficacy of serpins as therapeutic agents for HIV in vivo has not yet been demonstrated. In the present study, we show that heparin-activated antithrombin III (hep-ATIII), a member of the serpin family, significantly inhibits lentiviral replication in a non-human primate model. We further demonstrate greater than one log10 reduction in plasma viremia in the nonhuman primate system by loading of hep-ATIII into anti-HLA-DR immunoliposomes, which target tissue reservoirs of viral replication. We also demonstrate the utility of hep-ATIIII as a potential salvage agent for HIV strains resistant to standard anti-retroviral treatment. Finally, we applied gene-expression arrays to analyze hep-ATIII-induced host cell interactomes and found that downstream of hep-ATIII, two independent gene networks were modulated by host factors prostaglandin synthetase-2, ERK1/2 and NFκB. Ultimately, understanding how serpins, such as hep-ATIII, regulate host responses during HIV infection may reveal new avenues for therapeutic intervention