The thermodynamics of collapsing molecular cloud cores using smoothed particle hydrodynamics with radiative transfer

We present the results of a series of calculations studying the collapse of molecular cloud cores performed using a three-dimensional smoothed particle hydr odynamics code with radiative transfer in the flux-limited diffusion approximation. The opacities and specific heat capacities are identical for each calculation. However, we find that the temperature evolution during the simulations varies significantly when starting from different initial conditions. Even spherically-symmetric clouds with different initial densities show markedly different development. We conclude that simple barotropic equations of state like those used in some previous calculations provide at best a crude approximation to the thermal behaviour of the gas. Radiative transfer is necessary to obtain accurate temperatures.Comment: 8 pages, 9 figures, accepted for publication in MNRA

A simplified model of the Martian atmosphere - Part 1: a diagnostic analysis

In this paper we derive a reduced-order approximation to the vertical and horizontal structure of a simplified model of the baroclinically unstable Martian atmosphere. The original model uses the full hydrostatic primitive equations on a sphere, but has only highly simplified schemes to represent the detailed physics of the Martian atmosphere, e.g. forcing towards a plausible zonal mean temperature state using Newtonian cooling. Three different norms are used to monitor energy conversion processes in the model and are then compared. When four vertical modes (the barotropic and first three baroclinic modes) are retained in the reduced-order approximation, the correlation norm captures approximately 90% of the variance, while the kinetic energy and total energy norms capture approximately 83% and 78% of the kinetic and total energy respectively. We show that the leading order Proper Orthogonal Decomposition (POD) modes represent the dominant travelling waves in the baroclinically-unstable, winter hemisphere. In part 2 of our study we will develop a hierarchy of truncated POD-Galerkin expansions of the model equations using up to four vertical modes

A simplified model of the Martian atmosphere - Part 2: a POD-Galerkin analysis

In Part I of this study Whitehouse et al. (2005) performed a diagnostic analysis of a simplied model of the Martian atmosphere, in which topography was absent and in which heating was modelled as Newtonian relaxation towards a zonally symmetric equilibrium temperature field. There we derived a reduced-order approximation to the vertical and the horizonal structure of the baroclinically unstable Martian atmosphere, retaining only the barotropic mode and the leading order baroclinic modes. Our objectives in Part II of the study are to incorporate these approximations into a Proper Orthogonal Decomposition-Galerkin expansion of the spherical quasi-geostrophic model in order to derive hierarchies of nonlinear ordinary differential equations for the time-varying coefficients of the spatial structures. Two different vertical truncations are considered, as well as three different norms and 3 different Galerkin truncations. We investigate each in turn, using tools from bifurcation theory, to determine which of the systems most closely resembles the data for which the original diagnostics were performed

FISH: A 3D parallel MHD code for astrophysical applications

FISH is a fast and simple ideal magneto-hydrodynamics code that scales to ~10 000 processes for a Cartesian computational domain of ~1000^3 cells. The simplicity of FISH has been achieved by the rigorous application of the operator splitting technique, while second order accuracy is maintained by the symmetric ordering of the operators. Between directional sweeps, the three-dimensional data is rotated in memory so that the sweep is always performed in a cache-efficient way along the direction of contiguous memory. Hence, the code only requires a one-dimensional description of the conservation equations to be solved. This approach also enable an elegant novel parallelisation of the code that is based on persistent communications with MPI for cubic domain decomposition on machines with distributed memory. This scheme is then combined with an additional OpenMP parallelisation of different sweeps that can take advantage of clusters of shared memory. We document the detailed implementation of a second order TVD advection scheme based on flux reconstruction. The magnetic fields are evolved by a constrained transport scheme. We show that the subtraction of a simple estimate of the hydrostatic gradient from the total gradients can significantly reduce the dissipation of the advection scheme in simulations of gravitationally bound hydrostatic objects. Through its simplicity and efficiency, FISH is as well-suited for hydrodynamics classes as for large-scale astrophysical simulations on high-performance computer clusters. In preparation for the release of a public version, we demonstrate the performance of FISH in a suite of astrophysically orientated test cases.Comment: 27 pages, 11 figure

Neuraminidase Activity in \u3cem\u3eDiplococcus pneumoniae\u3c/em\u3e

Kelly, R. T. (Marquette University School of Medicine, Milwaukee, Wis.), D. Greiff, and S. Farmer. Neuraminidase activity in Diplococcus pneumoniae. J. Bacteriol. 91:601–603. 1966.—A method for the quantitation of neuraminidase in the presence of N-acetylneuraminic acid aldolase is described. The neuraminidase content of Diplococcus pneumoniae was found to be dependent on the media employed for growth; the highest enzyme activity per milligram of bacterial protein was obtained with Todd-Hewitt broth. Neuraminidase production was stimulated in D. pneumoniae by the addition of N-acetylneuraminlactose, N-acetylneuraminic acid, or N-acetylmannosamine to the growth medium. Three rough strains of D. pneumoniae, which were nonpathogenic for mice, lacked neuraminidase activity. Seven of 12 smooth strains contained neuraminidase; enzyme activity was not detected in the remaining 5 smooth strains. There was no correlation between the presence of neuraminidase activity and the capsular type or between neuraminidase production and animal virulence

Assessment and diagnosis of Developmental Language Disorder: The experiences of speech and language therapists

© The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).Background: For many years research and practice have noted the impact of the heterogeneous nature of Developmental Language Disorder (also known as language impairment or specific language impairment) on diagnosis and assessment. Recent research suggests the disorder is not restricted to the language domain and against this background, the challenge for the practitioner is to provide accurate assessment and effective therapy. The language practitioner aims to support the child and their carers to achieve the best outcomes. However, little is known about the experiences of the language practitioner in the assessment process, in contrast to other childhood disorders, yet their expertise is central in the assessment and diagnosis of children with language disorder. Aims: This study aimed to provide a detailed qualitative description of the experiences of speech and language therapists involved in the assessment and diagnosis of children with Developmental Language Disorder. Methods & Procedures: The qualitative study included three focus groups to provide a credible and rich description of the experiences of speech and language therapists involved in the assessment of Developmental Language Disorder. The speech and language therapists who participated in the study were recruited from three NHS Trusts across the UK and all were directly involved in the assessment and diagnosis procedures. The lengths of practitioner experience ranged from 2 years to 38 years. The data was analysed using a thematic analysis in accordance with the principles set out by Braun & Clarke (2006). Outcomes & Results: The data showed a number of key themes concerning the experiences of speech and language therapists in assessing children with Developmental Language Disorder (DLD). These themes ranged from the participants’ experiences of the barriers to early referral, challenges for assessment and the concerns over continued future support. Conclusions & Implications: This study provides first-hand evidence from speech and language therapists in the assessment of children with Developmental Language Disorder, drawing together experiences from language practitioners from different regions. The findings provide insight to the barriers to referral, the potential variations in the assessment process, the role of practitioner expertise and the challenges faced them. The importance of early intervention, useful assessment tools and future support were expressed. Taken together, the results relate to some issues to be addressed on a practical level and a continuing need for initiatives to raise awareness of DLD in the public domain.Peer reviewe

Examining memory for ritualized gesture in complex causal sequences

Abstract: Humans have created and maintained an exponentially large and sophisticated behavioral corpus over evolutionary time. In no small part this was achieved due to our tendency to imitate behaviours rather than to emulate outcomes. This tendency, however, can lead to inefficiency and redundancy in our behavioral repertoires. Drawing on evidence from multiple fields of psychology, we propose two novel competing hypotheses. The ‘catalyst hypothesis’ suggests that low (but not high) proportions of ritualized gesture in instrumental action sequences will improve subsequent recall of the entire action sequence (without itself enhancing the instrumental utility of the sequence). Conversely, the ‘cost hypothesis’ suggests that increasing proportions of ritualized gesture will impair recall, due to the introduction of cognitive load. The null hypothesis states that ritualized gestures are neither beneficial nor costly. In a pre‐registered experiment, we presented participants with multiple versions of two complicated 2‐minute action sequences in which we varied the proportion of ritualized gesture. We then quantified the influence ritualized gesture had on recall for individuals gestures, overall outcomes, and described detail. We found clear evidence that high proportions of ritualized gestures impair recall for individual gestures and overall success, and weak evidence that low proportions increase overall success. At present, we may reject the null, but cannot rule out either of our competing hypotheses. We discuss potential implications for cultural evolution, and generate competing predictions that allow for adjudication between Ritual Modes theory (Whitehouse, 2004) and the ‘Cognitive Resource Depletion’ account of Religious Interaction (Schjoedt et al., 2013). All files (including data and syntax) are freely available at https://osf.io/spz68/

Glypican-1 Mediates Both Prion Protein Lipid Raft Association and Disease Isoform Formation

In prion diseases, the cellular form of the prion protein, PrPC, undergoes a conformational conversion to the infectious isoform, PrPSc. PrPC associates with lipid rafts through its glycosyl-phosphatidylinositol (GPI) anchor and a region in its N-terminal domain which also binds to heparan sulfate proteoglycans (HSPGs). We show that heparin displaces PrPC from rafts and promotes its endocytosis, suggesting that heparin competes with an endogenous raft-resident HSPG for binding to PrPC. We then utilised a transmembrane-anchored form of PrP (PrP-TM), which is targeted to rafts solely by its N-terminal domain, to show that both heparin and phosphatidylinositol-specific phospholipase C can inhibit its association with detergent-resistant rafts, implying that a GPI-anchored HSPG targets PrPC to rafts. Depletion of the major neuronal GPI-anchored HSPG, glypican-1, significantly reduced the raft association of PrP-TM and displaced PrPC from rafts, promoting its endocytosis. Glypican-1 and PrPC colocalised on the cell surface and both PrPC and PrPSc co-immunoprecipitated with glypican-1. Critically, treatment of scrapie-infected N2a cells with glypican-1 siRNA significantly reduced PrPSc formation. In contrast, depletion of glypican-1 did not alter the inhibitory effect of PrPC on the β-secretase cleavage of the Alzheimer's amyloid precursor protein. These data indicate that glypican-1 is a novel cellular cofactor for prion conversion and we propose that it acts as a scaffold facilitating the interaction of PrPC and PrPSc in lipid rafts