4,685 research outputs found
Some limit theorems for the second-order Markov chains indexed by a general infinite tree with uniform bounded degree
An Electronic Mach-Zehnder Interferometer
Double-slit electron interferometers, fabricated in high mobility
two-dimensional electron gas (2DEG), proved to be very powerful tools in
studying coherent wave-like phenomena in mesoscopic systems. However, they
suffer from small fringe visibility due to the many channels in each slit and
poor sensitivity to small currents due to their open geometry. Moreover, the
interferometers do not function in a high magnetic field, namely, in the
quantum Hall effect (QHE) regime, since it destroys the symmetry between left
and right slits. Here, we report on the fabrication and operation of a novel,
single channel, two-path electron interferometer that functions in a high
magnetic field. It is the first electronic analog of the well-known optical
Mach-Zehnder (MZ) interferometer. Based on single edge state and closed
geometry transport in the QHE regime the interferometer is highly sensitive and
exhibits very high visibility (62%). However, the interference pattern decays
precipitously with increasing electron temperature or energy. While we do not
understand the reason for the dephasing we show, via shot noise measurement,
that it is not a decoherence process that results from inelastic scattering
events.Comment: to appear in Natur
Pseudolite-augmented GPS for deformation monitoring : analysis and experimental study
Author name used in this publication: 何秀凤Author name used in this publication: 陈永奇Author name used in this publication: 桑文刚Author name used in this publication: 杨光title in Traditional Chinese: 偽衛星增強GPS方法在變形監測中的應用研究 (英文)Journal title in Traditional Chinese: 測繪學報2006-2007 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe
Study on bearing performance of friction pile foundation in complicated soil-layers
2003-2004 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe
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The rise of the machines: A state-of-the-art technical review on process modelling and machine learning within hydrogen production with carbon capture
Data availability:
No data was used for the research described in the article.Copyright © 2023 The Authors. This study aims to present a compendious yet technical scrutiny of the current trends in process modelling as well as the implementation of machine learning within combined hydrogen production and carbon capture (i.e. blue hydrogen). The paper is intended to accurately portray the role that machine learning is anticipated to play within research and development in blue hydrogen production in the forthcoming years. This covers the implementation of machine learning at both material and process development levels. The paper provides a concise overview of the current trends in blue hydrogen production, as well as an intro to machine learning and process modelling within the same context. We have reinforced our paper by first summarising a brief description of the key “tools” used in machine learning and process modelling, before painstakingly examining the implementation of these techniques in blue hydrogen production and the less-discovered merits and de-merits.
Ultimately, the paper depicts a clear picture of the advancements in machine learning and the major role it is expected to play in accelerating research and development in blue hydrogen production on both material and process development fronts. The paper strives to shed some light on the key advantages that machine learning has to offer in blue hydrogen for future research work.UK Engineering and Physical Sciences Research Council (EPSRC) via the grant “Multiphysics and multiscale modelling for safe and feasible CO2 capture and storage - EP/T033940/1”; EPSRC Doctoral Training Partnerships (DTP) award, EP/T518116/1 (project reference: 2688399)
Case Report: The Clinical Toxicity of Dimethylamine Borane
Context: Dimethylamine borane (DMAB) is a reducing agent used in nonelectric plating of semiconductors. Exposures are usually through occupational contact. We report here four cases of people who suffered from work-related exposure to DMAB. Case presentation: Three patients exposed to DMAB decontaminated immediately by drinking a lot of water; they reported dizziness, nausea, diarrhea 6–8 hr later. The other patient did not decontaminate at once, and he suffered from more severe symptoms, including dizziness, nausea, limb numbness, slurred speech, irritable mood, and ataxia 13 hr later. Magnetic resonance imaging showed symmetric lesions with hyperintensity on T2WI and FLAIR in bilateral cerebellar dantate nuclei. This patient was readmitted to the hospital due to difficulty in walking and climbing 18 days after exposure. Lower leg weakness and drop foot were found bilaterally. A nerve conduction study revealed polyneuropathy with motor-predominant axonal degeneration. This patient receives regular outpatient followups and still walks with a clumsy gait and has difficulty with hand-grasping activity. Discussion: This case study demonstrates that DMAB is highly toxic to humans through any route of exposure, and dermal absorption is the major route of neurotoxicity. DMAB induces acute cortical and cerebellar injuries and delayed peripheral neuropathy. Relevance: Further investigation of the toxic mechanism of DMAB is warranted. Early decontamination with copious water is the best current treatment for exposure to DMAB
Estimation of heritability from limited family data using genome-wide identity-by-descent sharing
<p>Abstract</p> <p>Background</p> <p>In classical pedigree-based analysis, additive genetic variance is estimated from between-family variation, which requires the existence of larger phenotyped and pedigreed populations involving numerous families (parents). However, estimation is often complicated by confounding of genetic and environmental family effects, with the latter typically occurring among full-sibs. For this reason, genetic variance is often inferred based on covariance among more distant relatives, which reduces the power of the analysis. This simulation study shows that genome-wide identity-by-descent sharing among close relatives can be used to quantify additive genetic variance solely from within-family variation using data on extremely small family samples.</p> <p>Methods</p> <p>Identity-by-descent relationships among full-sibs were simulated assuming a genome size similar to that of humans (effective number of loci ~80). Genetic variance was estimated from phenotypic data assuming that genomic identity-by-descent relationships could be accurately re-created using information from genome-wide markers. The results were compared with standard pedigree-based genetic analysis.</p> <p>Results</p> <p>For a polygenic trait and a given number of phenotypes, the most accurate estimates of genetic variance were based on data from a single large full-sib family only. Compared with classical pedigree-based analysis, the proposed method is more robust to selection among parents and for confounding of environmental and genetic effects. Furthermore, in some cases, satisfactory results can be achieved even with less ideal data structures, i.e., for selectively genotyped data and for traits for which the genetic variance is largely under the control of a few major genes.</p> <p>Conclusions</p> <p>Estimation of genetic variance using genomic identity-by-descent relationships is especially useful for studies aiming at estimating additive genetic variance of highly fecund species, using data from small populations with limited pedigree information and/or few available parents, i.e., parents originating from non-pedigreed or even wild populations.</p
Oxaliplatin-dacarbazine combination chemotherapy for the treatment of advanced soft tissue sarcoma of the limbs
<p>Abstract</p> <p>Background</p> <p>This study was designed to explore the feasibility, safety, and outcomes of pre-operative oxaliplatin-dacarbazine combination therapy for the treatment of advanced soft tissue sarcoma (STS) of the limb.</p> <p>Patients and Methods</p> <p>Between November 2005 and November 2008, 31 patients with advanced limb STS classified with stage IV STS were randomly assigned into experimental or control groups, and both were given 2 cycles of chemotherapy before undergoing surgery. The regimen for the experimental group was oxaliplatin (120 mg/m<sup>2</sup>, d<sub>1</sub>) in combination with dacarbazine (175 mg/m<sup>2</sup>, d<sub>13</sub>), while that for the control group was a standard vincristine, epirubicin, cyclophosphamide therapy. Operations were carried out four weeks after the second chemotherapy cycle, followed by another 24 more chemotherapy cycles of the previous regimen.</p> <p>Results</p> <p>Following preoperative chemotherapy, the experimental group exhibited a significant improvement in tumor regression compared to controls. Both regimens were well-tolerated, and no significant differences in adverse reactions were noted. At a median follow-up of 24 months, 28 patients were still alive and had normal limb function. The progression free survival rate of the experimental group was significantly higher than that of the control group (10/15 vs. 4/16, <it>p </it>< 0.05).</p> <p>Conclusion</p> <p>Oxaliplatin- dacarbazine neoadjuvant/adjuvant chemotherapy improved the prognosis of patients with advanced limb STS in comparison with vincristine, epirubicin, cyclophosphamide combination therapy.</p
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