2,703 research outputs found
Rural Illinois in the 1990s: On the Rebound?
Rural areas of Illinois experienced a widespread population rebound between 1990 and 1995.2 These recent population gains in Illinois are consistent with a broader rural population growth revival nationwide. Rural Illinois gain nearly 24,000 residents between 1990 and 1995, according to recently released estimates by the U.S. Census Bureau.3 The population grew in 47 of the 74 nonmetropolitan counties in Illinois during the period. Migration to rural areas accounted for most of this population gain. Most urban areas in Illinois also gained population during the first half of the 1990s. The recent population gains in rural Illinois are modest, but they represent a significant change from the substantial population losses in the same areas during the 1980s
High temperature ceramics for automobile gas turbines. Part 2: Development of ceramic components
The development of ceramic components for automobile gas turbine engines is described with attention given to the steady and unsteady thermal conditions the ceramics will experience, and their anti-corrosion and strain-resistant properties. The ceramics considered for use in the automobile turbines include hot-pressed Si3N4, reaction-sintered, isostatically pressed Si3N4, hot-pressed SiC, reaction-bonded SiC, and glass ceramics. Attention is given to the stress analysis of ceramic structures and the state of the art of ceramic structural technology is reviewed, emphasizing the use of ceramics for combustion chambers and ceramic shrouded turbomachinery (a fully ceramic impeller)
Interdisciplinary Study of Combating Hybrid Threats
NPS NRP Project PosterOur nation and allies are coming under increased attack by states and non-state actors who seek to exploit our vulnerabilities through employ non-attributable actions below the threshold of war in order to weaken our competitive advantage across all domains, steal intellectual property, or undermine the cohesiveness of our alliances. These hybrid threats can be in the form of hacking networks, cyber-attacks against critical infrastructure, disinformation campaigns, electoral interference, etc. These unconventional actions cannot be responsibly answered with conventional military forces and thus require a new set of response options. This research seeks to answer three broad questions on hybrid threats: what are the current hybrid threat challenges, how should we respond, and what do we need in order to execute such a response? The answers to these questions will achieve the main objectives of this research. First, arrive at a common understanding on the concept of hybrid threats. Second, develop an analytical framework to support designing actions to address and combat hybrid threats. Lastly, identify key issues and capability gaps for further research. The research methodology will begin with understanding the current depth of knowledge on hybrid threats, then developing case states to expand this knowledge, and lastly developing an analytical framework to combat hybrid threats. The analytical framework will help assess the actor, domain(s), methods, and desired intentions and objectives.N7 - Warfighting DevelopmentThis research is supported by funding from the Naval Postgraduate School, Naval Research Program (PE 0605853N/2098). https://nps.edu/nrpChief of Naval Operations (CNO)Approved for public release. Distribution is unlimited.
Interdisciplinary Study of Combating Hybrid Threats
NPS NRP Executive SummaryOur nation and allies are coming under increased attack by states and non-state actors who seek to exploit our vulnerabilities through employ non-attributable actions below the threshold of war in order to weaken our competitive advantage across all domains, steal intellectual property, or undermine the cohesiveness of our alliances. These hybrid threats can be in the form of hacking networks, cyber-attacks against critical infrastructure, disinformation campaigns, electoral interference, etc. These unconventional actions cannot be responsibly answered with conventional military forces and thus require a new set of response options. This research seeks to answer three broad questions on hybrid threats: what are the current hybrid threat challenges, how should we respond, and what do we need in order to execute such a response? The answers to these questions will achieve the main objectives of this research. First, arrive at a common understanding on the concept of hybrid threats. Second, develop an analytical framework to support designing actions to address and combat hybrid threats. Lastly, identify key issues and capability gaps for further research. The research methodology will begin with understanding the current depth of knowledge on hybrid threats, then developing case states to expand this knowledge, and lastly developing an analytical framework to combat hybrid threats. The analytical framework will help assess the actor, domain(s), methods, and desired intentions and objectives.N7 - Warfighting DevelopmentThis research is supported by funding from the Naval Postgraduate School, Naval Research Program (PE 0605853N/2098). https://nps.edu/nrpChief of Naval Operations (CNO)Approved for public release. Distribution is unlimited.
Reply: Costs of managing adverse events in the treatment of first-line metastatic renal cell carcinoma: bevacizumab in combination with interferon-α2a compared with sunitinib
Global citizenship as the completion of cosmopolitanism
A conception of global citizenship should not be viewed as separate from, or synonymous with, the cosmopolitan moral orientation, but as a primary component of it. Global citizenship is fundamentally concerned with individual
moral requirements in the global frame. Such requirements, framed here as belonging to the category of individual cosmopolitanism, offer guidelines on right action in the context of global human community. They are complementary
to the principles of moral cosmopolitanism – those to be used in assessing the justice of global institutions and practices – that have been emphasised by cosmopolitan political theorists. Considering principles of individual and moral cosmopolitanism together can help to provide greater clarity concerning individual duties in the absence of fully global institutions, as well as clarity on individual obligations of justice in relation to emerging and still-developing trans-state institutions
PCN17 COST OF MANAGING SIDE EFFECTS OF FIRST-LINE THERAPY FOR METASTATIC RENAL CELL CARCINOMA (MRCC) IN GERMANY, FRANCE, UK AND ITALY: BEVACIZUMAB (BEV) + INTERFERON-ALPHA2A COMPARED WITH SUNITINIB
Costs of managing adverse events in the treatment of first-line metastatic renal cell carcinoma: Bevacizumab in combination with interferon-α2a compared with sunitinib
Background: Bevacizumab plus interferon-α2a (IFN) prolongs progression-free survival to>10 months, which is comparable with sunitinib as first-line treatment of metastatic renal cell carcinoma (RCC). The two regimens have different tolerability profiles; therefore, costs for managing adverse events may be an important factor in selecting therapy.Methods: Costs of managing adverse events affecting patients with metastatic RCC eligible for treatment with bevacizumab plus IFN or sunitinib were evaluated using a linear decision analytical model. Management costs were calculated from the published incidence of adverse events and health-care costs for treating adverse events in the United Kingdom, Germany, France and Italy.Results: Adverse event management costs were higher for sunitinib than for bevacizumab plus IFN. The average cost per patient for the management of grade 3-4 adverse events was markedly lower with bevacizumab plus IFN compared with sunitinib in the United Kingdom (\[euro]1475 vs \[euro]804), Germany (\[euro]1785 vs \[euro]1367), France (\[euro]2590 vs \[euro]1618) and Italy (\[euro]891 vs \[euro]402). The main cost drivers were lymphopaenia, neutropaenia, thrombocytopaenia, leucopaenia and fatigue/asthaenia for sunitinib; and proteinuria, fatigue/asthaenia, bleeding, anaemia and gastrointestinal perforation for bevacizumab plus IFN.Conclusion: The costs of managing adverse events are lower for bevacizumab plus IFN than for sunitinib. The potential for cost savings should be considered when selecting treatments for RCC
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